Olfaction and Anxiety Are Differently Associated in Men and Women in Cognitive Physiological and Pathological Aging. Cieri, F., Cera, N., Ritter, A., Cordes, D., & Caldwell, J. Z. K. Journal of Clinical Medicine, 12(6):2338, March, 2023.
Olfaction and Anxiety Are Differently Associated in Men and Women in Cognitive Physiological and Pathological Aging [link]Paper  doi  abstract   bibtex   
Background: Olfaction impairment in aging is associated with increased anxiety. We explored this association in cognitively healthy controls (HCs), Mild Cognitive Impairment (MCI) and Parkinson’s disease (PD) patients. Both olfaction and anxiety have sex differences, therefore we also investigated these variances. Objectives: Investigate the association of olfaction with anxiety in three distinct clinical categories of aging, exploring the potential role of sex. Methods: 117 subjects (29 HCs, 43 MCI, and 45 PD patients) were assessed for olfaction and anxiety. We used regression models to determine whether B-SIT predicted anxiety and whether sex impacted that relationship. Results: Lower olfaction was related to greater anxiety traits in all groups (HCs: p = 0.015; MCI: p = 0.001 and PD: p = 0.038), significantly differed by sex. In fact, in HCs, for every unit increase in B-SIT, anxiety traits decreased by 7.63 in men (p = 0.009) and 1.5 in women (p = 0.225). In MCI patients for every unit increase in B-SIT, anxiety traits decreased by 1.19 in men (p = 0.048) and 3.03 in women (p = 0.0036). Finally, in PD patients for every unit increase in B-SIT, anxiety traits decreased by 1.73 in men (p = 0.004) and 0.41 in women (p = 0.3632). Discussion: Olfaction and anxiety are correlated in all three distinct diagnostic categories, but differently in men and women.
@article{cieri_olfaction_2023,
	title = {Olfaction and {Anxiety} {Are} {Differently} {Associated} in {Men} and {Women} in {Cognitive} {Physiological} and {Pathological} {Aging}},
	volume = {12},
	issn = {2077-0383},
	url = {https://www.mdpi.com/2077-0383/12/6/2338},
	doi = {10.3390/jcm12062338},
	abstract = {Background: Olfaction impairment in aging is associated with increased anxiety. We explored this association in cognitively healthy controls (HCs), Mild Cognitive Impairment (MCI) and Parkinson’s disease (PD) patients. Both olfaction and anxiety have sex differences, therefore we also investigated these variances. Objectives: Investigate the association of olfaction with anxiety in three distinct clinical categories of aging, exploring the potential role of sex. Methods: 117 subjects (29 HCs, 43 MCI, and 45 PD patients) were assessed for olfaction and anxiety. We used regression models to determine whether B-SIT predicted anxiety and whether sex impacted that relationship. Results: Lower olfaction was related to greater anxiety traits in all groups (HCs: p = 0.015; MCI: p = 0.001 and PD: p = 0.038), significantly differed by sex. In fact, in HCs, for every unit increase in B-SIT, anxiety traits decreased by 7.63 in men (p = 0.009) and 1.5 in women (p = 0.225). In MCI patients for every unit increase in B-SIT, anxiety traits decreased by 1.19 in men (p = 0.048) and 3.03 in women (p = 0.0036). Finally, in PD patients for every unit increase in B-SIT, anxiety traits decreased by 1.73 in men (p = 0.004) and 0.41 in women (p = 0.3632). Discussion: Olfaction and anxiety are correlated in all three distinct diagnostic categories, but differently in men and women.},
	language = {en},
	number = {6},
	urldate = {2024-02-26},
	journal = {Journal of Clinical Medicine},
	author = {Cieri, Filippo and Cera, Nicoletta and Ritter, Aaron and Cordes, Dietmar and Caldwell, Jessica Zoe Kirkland},
	month = mar,
	year = {2023},
	pages = {2338},
}

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