@article{ cilliers_pyridoxal-5-phosphate_2010,
  title = {Pyridoxal-5-phosphate plasma concentrations in children receiving tuberculosis chemotherapy including isoniazid},
  volume = {99},
  issn = {1651-2227},
  doi = {10.1111/j.1651-2227.2010.01696.x},
  abstract = {AIM: Little is known about pyridoxine nutriture of children treated with isoniazid (INH) regimens. This study documents plasma pyridoxal 5'-phosphate (PLP) concentrations in children, HIV-infected and HIV-uninfected, receiving INH regimens.
METHODS: Children from the Western Cape of South Africa hospitalized for tuberculosis (TB) management were studied. Plasma PLP concentrations were determined on enrolment, 1-month after commencing TB treatment, and again after 4-month's treatment. The children received a supplement meeting pyridoxine requirements.
RESULTS: Nineteen HIV-infected and 33 HIV-uninfected children received INH (dosage range 4-20 mg/kg) daily. Mean PLP plasma concentrations on enrolment were 8.32 (SD 6.75) ng/mL and 11.28 (SD 3.02) ng/mL in HIV-infected and HIV-uninfected children, respectively (p = 0.11) and after 4-month's treatment 6.75 (SD 2.71) ng/mL and 14.76 (SD 7.96) ng/mL (p {\textless} 0.001). On enrolment 9 (50%) HIV-infected and 5 (15%) HIV-uninfected children (p = 0.016) had suboptimal PLP concentrations ({\textless}6 ng/mL); after 4-month's treatment 8 (42%) and 2 (6%) (p = 0.004).
CONCLUSION: Plasma PLP concentrations in children treated for TB were low on enrolment in HIV-infected and HIV-uninfected children; after 4-month's treatment low values were still common in HIV-infected children. Additional pyridoxine supplementation of malnourished children treated for tuberculosis is advisable, particularly those HIV-infected.},
  language = {eng},
  number = {5},
  journal = {Acta Paediatrica (Oslo, Norway: 1992)},
  author = {Cilliers, K. and Labadarios, D. and Schaaf, H. S. and Willemse, M. and Maritz, J. S. and Werely, C. J. and Hussey, G. and Donald, P. R.},
  month = {May},
  year = {2010},
  pmid = {20146723},
  keywords = {AIDS-Related Opportunistic Infections, Adolescent, Antitubercular Agents, Child, Child, Preschool, Female, Genotype, HIV Infections, Humans, Infant, Isoniazid, Male, Pyridoxal Phosphate, South Africa, Tuberculosis},
  pages = {705--710}
}

{"_id":"2hkuqSb8cvDHzKrDS","bibbaseid":"cilliers-labadarios-schaaf-willemse-maritz-werely-hussey-donald-pyridoxal5phosphateplasmaconcentrationsinchildrenreceivingtuberculosischemotherapyincludingisoniazid-2010","downloads":0,"creationDate":"2015-06-25T09:01:23.427Z","title":"Pyridoxal-5-phosphate plasma concentrations in children receiving tuberculosis chemotherapy including isoniazid","author_short":["Cilliers, K.","Labadarios, D.","Schaaf, H.<nbsp>S.","Willemse, M.","Maritz, J.<nbsp>S.","Werely, C.<nbsp>J.","Hussey, G.","Donald, P.<nbsp>R."],"year":2010,"bibtype":"article","biburl":"https://api.zotero.org/users/559844/collections/2NP2XXNP/items?key=hqNfyop631uL1rdCcM8Pjttm&format=bibtex&limit=100","bibdata":{"abstract":"AIM: Little is known about pyridoxine nutriture of children treated with isoniazid (INH) regimens. This study documents plasma pyridoxal 5'-phosphate (PLP) concentrations in children, HIV-infected and HIV-uninfected, receiving INH regimens. METHODS: Children from the Western Cape of South Africa hospitalized for tuberculosis (TB) management were studied. Plasma PLP concentrations were determined on enrolment, 1-month after commencing TB treatment, and again after 4-month's treatment. The children received a supplement meeting pyridoxine requirements. RESULTS: Nineteen HIV-infected and 33 HIV-uninfected children received INH (dosage range 4-20 mg/kg) daily. Mean PLP plasma concentrations on enrolment were 8.32 (SD 6.75) ng/mL and 11.28 (SD 3.02) ng/mL in HIV-infected and HIV-uninfected children, respectively (p = 0.11) and after 4-month's treatment 6.75 (SD 2.71) ng/mL and 14.76 (SD 7.96) ng/mL (p \\textless 0.001). On enrolment 9 (50%) HIV-infected and 5 (15%) HIV-uninfected children (p = 0.016) had suboptimal PLP concentrations (\\textless6 ng/mL); after 4-month's treatment 8 (42%) and 2 (6%) (p = 0.004). CONCLUSION: Plasma PLP concentrations in children treated for TB were low on enrolment in HIV-infected and HIV-uninfected children; after 4-month's treatment low values were still common in HIV-infected children. Additional pyridoxine supplementation of malnourished children treated for tuberculosis is advisable, particularly those HIV-infected.","author":["Cilliers, K.","Labadarios, D.","Schaaf, H. S.","Willemse, M.","Maritz, J. S.","Werely, C. J.","Hussey, G.","Donald, P. R."],"author_short":["Cilliers, K.","Labadarios, D.","Schaaf, H.<nbsp>S.","Willemse, M.","Maritz, J.<nbsp>S.","Werely, C.<nbsp>J.","Hussey, G.","Donald, P.<nbsp>R."],"bibtex":"@article{ cilliers_pyridoxal-5-phosphate_2010,\n title = {Pyridoxal-5-phosphate plasma concentrations in children receiving tuberculosis chemotherapy including isoniazid},\n volume = {99},\n issn = {1651-2227},\n doi = {10.1111/j.1651-2227.2010.01696.x},\n abstract = {AIM: Little is known about pyridoxine nutriture of children treated with isoniazid (INH) regimens. This study documents plasma pyridoxal 5'-phosphate (PLP) concentrations in children, HIV-infected and HIV-uninfected, receiving INH regimens.\nMETHODS: Children from the Western Cape of South Africa hospitalized for tuberculosis (TB) management were studied. Plasma PLP concentrations were determined on enrolment, 1-month after commencing TB treatment, and again after 4-month's treatment. The children received a supplement meeting pyridoxine requirements.\nRESULTS: Nineteen HIV-infected and 33 HIV-uninfected children received INH (dosage range 4-20 mg/kg) daily. Mean PLP plasma concentrations on enrolment were 8.32 (SD 6.75) ng/mL and 11.28 (SD 3.02) ng/mL in HIV-infected and HIV-uninfected children, respectively (p = 0.11) and after 4-month's treatment 6.75 (SD 2.71) ng/mL and 14.76 (SD 7.96) ng/mL (p {\\textless} 0.001). On enrolment 9 (50%) HIV-infected and 5 (15%) HIV-uninfected children (p = 0.016) had suboptimal PLP concentrations ({\\textless}6 ng/mL); after 4-month's treatment 8 (42%) and 2 (6%) (p = 0.004).\nCONCLUSION: Plasma PLP concentrations in children treated for TB were low on enrolment in HIV-infected and HIV-uninfected children; after 4-month's treatment low values were still common in HIV-infected children. Additional pyridoxine supplementation of malnourished children treated for tuberculosis is advisable, particularly those HIV-infected.},\n language = {eng},\n number = {5},\n journal = {Acta Paediatrica (Oslo, Norway: 1992)},\n author = {Cilliers, K. and Labadarios, D. and Schaaf, H. S. and Willemse, M. and Maritz, J. S. and Werely, C. J. and Hussey, G. and Donald, P. R.},\n month = {May},\n year = {2010},\n pmid = {20146723},\n keywords = {AIDS-Related Opportunistic Infections, Adolescent, Antitubercular Agents, Child, Child, Preschool, Female, Genotype, HIV Infections, Humans, Infant, Isoniazid, Male, Pyridoxal Phosphate, South Africa, Tuberculosis},\n pages = {705--710}\n}","bibtype":"article","doi":"10.1111/j.1651-2227.2010.01696.x","id":"cilliers_pyridoxal-5-phosphate_2010","issn":"1651-2227","journal":"Acta Paediatrica (Oslo, Norway: 1992)","key":"cilliers_pyridoxal-5-phosphate_2010","keywords":"AIDS-Related Opportunistic Infections, Adolescent, Antitubercular Agents, Child, Child, Preschool, Female, Genotype, HIV Infections, Humans, Infant, Isoniazid, Male, Pyridoxal Phosphate, South Africa, Tuberculosis","language":"eng","month":"May","number":"5","pages":"705--710","pmid":"20146723","title":"Pyridoxal-5-phosphate plasma concentrations in children receiving tuberculosis chemotherapy including isoniazid","type":"article","volume":"99","year":"2010","bibbaseid":"cilliers-labadarios-schaaf-willemse-maritz-werely-hussey-donald-pyridoxal5phosphateplasmaconcentrationsinchildrenreceivingtuberculosischemotherapyincludingisoniazid-2010","role":"author","urls":{},"keyword":["AIDS-Related Opportunistic Infections","Adolescent","Antitubercular Agents","Child","Child","Preschool","Female","Genotype","HIV Infections","Humans","Infant","Isoniazid","Male","Pyridoxal Phosphate","South Africa","Tuberculosis"],"downloads":0},"search_terms":["pyridoxal","phosphate","plasma","concentrations","children","receiving","tuberculosis","chemotherapy","including","isoniazid","cilliers","labadarios","schaaf","willemse","maritz","werely","hussey","donald"],"keywords":["aids-related opportunistic infections","adolescent","antitubercular agents","child","child","preschool","female","genotype","hiv infections","humans","infant","isoniazid","male","pyridoxal phosphate","south africa","tuberculosis"],"authorIDs":[],"dataSources":["vtFqZHBhXLQtCKytZ"]}