EGF-ERBB signalling: towards the systems level. Citri, A. & Yarden, Y. Nat Rev Mol Cell Biol, 7(7):505-516, 7, 2006.
EGF-ERBB signalling: towards the systems level [link]Website  abstract   bibtex   
Signalling through the ERBB/HER receptors is intricately involved in human cancer and already serves as a target for several cancer drugs. Because of its inherent complexity, it is useful to envision ERBB signalling as a bow-tie-configured, evolvable network, which shares modularity, redundancy and control circuits with robust biological and engineered systems. Because network fragility is an inevitable trade-off of robustness, systems-level understanding is expected to generate therapeutic opportunities to intercept aberrant network activation.
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 title = {EGF-ERBB signalling: towards the systems level},
 type = {article},
 year = {2006},
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 keywords = {Animals,Endocytosis,Epidermal Growth Factor,Fee,Humans,Ligands,Models,Molecular,Oncogene Proteins v-erbB,Phosphatidyl,Physiological,Signal Transduction},
 pages = {505-516},
 volume = {7},
 websites = {http://dx.doi.org/10.1038/nrm1962},
 month = {7},
 institution = {Department of Biological Regulation, the Weizmann Institute of Science, 1 Hertzl Street, Rehovot 76100, Israel.},
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 abstract = {Signalling through the ERBB/HER receptors is intricately involved in human cancer and already serves as a target for several cancer drugs. Because of its inherent complexity, it is useful to envision ERBB signalling as a bow-tie-configured, evolvable network, which shares modularity, redundancy and control circuits with robust biological and engineered systems. Because network fragility is an inevitable trade-off of robustness, systems-level understanding is expected to generate therapeutic opportunities to intercept aberrant network activation.},
 bibtype = {article},
 author = {Citri, Ami and Yarden, Yosef},
 journal = {Nat Rev Mol Cell Biol},
 number = {7}
}
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