Causal role for sleep-dependent reactivation of learning-activated sensory ensembles for fear memory consolidation

Causal role for sleep-dependent reactivation of learning-activated sensory ensembles for fear memory consolidation. Clawson, B., Pickup, E., Ensing, A, Geneseo, L, & ... Nature …, nature.com, 2021.

Paper abstract bibtex

Learning-activated engram neurons play a critical role in memory recall. An untested hypothesis is that these same neurons play an instructive role in offline memory consolidation. Here we show that a visually-cued fear memory is consolidated during post-conditioning sleep in mice. We then use TRAP (targeted recombination in active populations) to genetically label or optogenetically manipulate primary visual cortex (V1) neurons responsive to the visual cue. Following fear conditioning, mice respond to activation …

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	author = {BC Clawson and EJ Pickup and A Ensing and L Geneseo and ...},
	type = {HTML},
	title = {Causal role for sleep-dependent reactivation of learning-activated sensory ensembles for fear memory consolidation},
	journal = {Nature …},
	publisher = {nature.com},
	url = {https://www.nature.com/articles/s41467-021-21471-2},
	fulltext = {https://www.nature.com/articles/s41467-021-21471-2},
	related = {https://scholar.google.com/scholar?q=related:nekSbenFkb4J:scholar.google.com/\&scioq=clawson+b+pickup+e+ensing+a+geneseo+l+shaver+j+%22gonzalez+amoretti%22+j+zhao+m+york+ak+jiang+s+aton+s+causal+role+for+%22sleep+dependent%22+reactivation+of+%22learning+activated%22+sensory+ensembles+for+fear+memory+consolidation+biorxiv+2020+jan+1\&hl=en\&as_sdt=0,5\&as_vis=1},
	year = {2021},
	abstract = {Learning-activated engram neurons play a critical role in memory recall. An untested hypothesis is that these same neurons play an instructive role in offline memory consolidation. Here we show that a visually-cued fear memory is consolidated during post-conditioning sleep in mice. We then use TRAP (targeted recombination in active populations) to genetically label or optogenetically manipulate primary visual cortex (V1) neurons responsive to the visual cue. Following fear conditioning, mice respond to activation …},

}

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