Pharmacological alterations of anxious behaviour in mice depending on both strain and the behavioural situation. Clément, Y., Guisquet, A. L., Venault, P., Chapouthier, G., & Belzung, C. PloS One, 4(11):e7745, 2009.
doi  abstract   bibtex   
A previous study comparing non-emotive mice from the strain C57BL/6/ByJ with ABP/Le mice showed ABP/Le to be more anxious in an open-field situation. In the present study, several compounds affecting anxiety were assayed on ABP/Le and C57BL/6/ByJ mice using three behavioural models of anxiety: the elevated plus-maze, the light-dark discrimination test and the free exploratory paradigm. The compounds used were the full benzodiazepine receptor agonist, chlordiazepoxide, and the antagonist, flumazenil, the GABA(A) antagonist, bicuculline, the full 5-HT(1A) agonist 8-OH-DPAT, and the mixed 5-HT(1A)/5-HT(1B) agonist, RU 24969. Results showed the effect of the compounds to be dependent on both the strain and the behavioural task. Several compounds found to be anxiolytic in ABP/Le mice had an anxiogenic effect on C57BL/6/ByJ mice. More behavioural changes were observed for ABP/Le in the elevated plus-maze, but the clearest findings for C57BL/6/ByJ mice were observed in the light-dark discrimination apparatus. These data demonstrate that anxious behaviour is a complex phenomenon which cannot be described by a single behavioural task nor by the action of a single compound.
@article{ clement_pharmacological_2009,
  title = {Pharmacological alterations of anxious behaviour in mice depending on both strain and the behavioural situation},
  volume = {4},
  issn = {1932-6203},
  doi = {10.1371/journal.pone.0007745},
  abstract = {A previous study comparing non-emotive mice from the strain C57BL/6/{ByJ} with {ABP}/Le mice showed {ABP}/Le to be more anxious in an open-field situation. In the present study, several compounds affecting anxiety were assayed on {ABP}/Le and C57BL/6/{ByJ} mice using three behavioural models of anxiety: the elevated plus-maze, the light-dark discrimination test and the free exploratory paradigm. The compounds used were the full benzodiazepine receptor agonist, chlordiazepoxide, and the antagonist, flumazenil, the {GABA}(A) antagonist, bicuculline, the full 5-{HT}(1A) agonist 8-{OH}-{DPAT}, and the mixed 5-{HT}(1A)/5-{HT}(1B) agonist, {RU} 24969. Results showed the effect of the compounds to be dependent on both the strain and the behavioural task. Several compounds found to be anxiolytic in {ABP}/Le mice had an anxiogenic effect on C57BL/6/{ByJ} mice. More behavioural changes were observed for {ABP}/Le in the elevated plus-maze, but the clearest findings for C57BL/6/{ByJ} mice were observed in the light-dark discrimination apparatus. These data demonstrate that anxious behaviour is a complex phenomenon which cannot be described by a single behavioural task nor by the action of a single compound.},
  language = {eng},
  number = {11},
  journal = {{PloS} One},
  author = {Clément, Yan and Le Guisquet, Anne-Marie and Venault, Patrice and Chapouthier, Georges and Belzung, Catherine},
  year = {2009},
  pmid = {19907641},
  pmcid = {PMC2770638},
  keywords = {8-Hydroxy-2-(di-n-propylamino)tetralin, Animals, Anxiety, Behavior, Animal, Benzodiazepines, Bicuculline, Chlordiazepoxide, Female, Indoles, Light, Male, Maze Learning, Mice, Mice, Inbred C57BL, Phosphorylation},
  pages = {e7745}
}

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