Pharmacological alterations of anxious behaviour in mice depending on both strain and the behavioural situation. Clément, Y., Guisquet, A. L., Venault, P., Chapouthier, G., & Belzung, C. PloS One, 4(11):e7745, 2009. doi abstract bibtex A previous study comparing non-emotive mice from the strain C57BL/6/ByJ with ABP/Le mice showed ABP/Le to be more anxious in an open-field situation. In the present study, several compounds affecting anxiety were assayed on ABP/Le and C57BL/6/ByJ mice using three behavioural models of anxiety: the elevated plus-maze, the light-dark discrimination test and the free exploratory paradigm. The compounds used were the full benzodiazepine receptor agonist, chlordiazepoxide, and the antagonist, flumazenil, the GABA(A) antagonist, bicuculline, the full 5-HT(1A) agonist 8-OH-DPAT, and the mixed 5-HT(1A)/5-HT(1B) agonist, RU 24969. Results showed the effect of the compounds to be dependent on both the strain and the behavioural task. Several compounds found to be anxiolytic in ABP/Le mice had an anxiogenic effect on C57BL/6/ByJ mice. More behavioural changes were observed for ABP/Le in the elevated plus-maze, but the clearest findings for C57BL/6/ByJ mice were observed in the light-dark discrimination apparatus. These data demonstrate that anxious behaviour is a complex phenomenon which cannot be described by a single behavioural task nor by the action of a single compound.
@article{ clement_pharmacological_2009,
title = {Pharmacological alterations of anxious behaviour in mice depending on both strain and the behavioural situation},
volume = {4},
issn = {1932-6203},
doi = {10.1371/journal.pone.0007745},
abstract = {A previous study comparing non-emotive mice from the strain C57BL/6/{ByJ} with {ABP}/Le mice showed {ABP}/Le to be more anxious in an open-field situation. In the present study, several compounds affecting anxiety were assayed on {ABP}/Le and C57BL/6/{ByJ} mice using three behavioural models of anxiety: the elevated plus-maze, the light-dark discrimination test and the free exploratory paradigm. The compounds used were the full benzodiazepine receptor agonist, chlordiazepoxide, and the antagonist, flumazenil, the {GABA}(A) antagonist, bicuculline, the full 5-{HT}(1A) agonist 8-{OH}-{DPAT}, and the mixed 5-{HT}(1A)/5-{HT}(1B) agonist, {RU} 24969. Results showed the effect of the compounds to be dependent on both the strain and the behavioural task. Several compounds found to be anxiolytic in {ABP}/Le mice had an anxiogenic effect on C57BL/6/{ByJ} mice. More behavioural changes were observed for {ABP}/Le in the elevated plus-maze, but the clearest findings for C57BL/6/{ByJ} mice were observed in the light-dark discrimination apparatus. These data demonstrate that anxious behaviour is a complex phenomenon which cannot be described by a single behavioural task nor by the action of a single compound.},
language = {eng},
number = {11},
journal = {{PloS} One},
author = {Clément, Yan and Le Guisquet, Anne-Marie and Venault, Patrice and Chapouthier, Georges and Belzung, Catherine},
year = {2009},
pmid = {19907641},
pmcid = {PMC2770638},
keywords = {8-Hydroxy-2-(di-n-propylamino)tetralin, Animals, Anxiety, Behavior, Animal, Benzodiazepines, Bicuculline, Chlordiazepoxide, Female, Indoles, Light, Male, Maze Learning, Mice, Mice, Inbred C57BL, Phosphorylation},
pages = {e7745}
}
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Results showed the effect of the compounds to be dependent on both the strain and the behavioural task. Several compounds found to be anxiolytic in ABP/Le mice had an anxiogenic effect on C57BL/6/ByJ mice. More behavioural changes were observed for ABP/Le in the elevated plus-maze, but the clearest findings for C57BL/6/ByJ mice were observed in the light-dark discrimination apparatus. These data demonstrate that anxious behaviour is a complex phenomenon which cannot be described by a single behavioural task nor by the action of a single compound.","author":["Clément, Yan","Guisquet, Anne-Marie Le","Venault, Patrice","Chapouthier, Georges","Belzung, Catherine"],"author_short":["Clément, Y.","Guisquet, A.<nbsp>L.","Venault, P.","Chapouthier, G.","Belzung, C."],"bibtex":"@article{ clement_pharmacological_2009,\n title = {Pharmacological alterations of anxious behaviour in mice depending on both strain and the behavioural situation},\n volume = {4},\n issn = {1932-6203},\n doi = {10.1371/journal.pone.0007745},\n abstract = {A previous study comparing non-emotive mice from the strain C57BL/6/{ByJ} with {ABP}/Le mice showed {ABP}/Le to be more anxious in an open-field situation. In the present study, several compounds affecting anxiety were assayed on {ABP}/Le and C57BL/6/{ByJ} mice using three behavioural models of anxiety: the elevated plus-maze, the light-dark discrimination test and the free exploratory paradigm. The compounds used were the full benzodiazepine receptor agonist, chlordiazepoxide, and the antagonist, flumazenil, the {GABA}(A) antagonist, bicuculline, the full 5-{HT}(1A) agonist 8-{OH}-{DPAT}, and the mixed 5-{HT}(1A)/5-{HT}(1B) agonist, {RU} 24969. Results showed the effect of the compounds to be dependent on both the strain and the behavioural task. Several compounds found to be anxiolytic in {ABP}/Le mice had an anxiogenic effect on C57BL/6/{ByJ} mice. More behavioural changes were observed for {ABP}/Le in the elevated plus-maze, but the clearest findings for C57BL/6/{ByJ} mice were observed in the light-dark discrimination apparatus. These data demonstrate that anxious behaviour is a complex phenomenon which cannot be described by a single behavioural task nor by the action of a single compound.},\n language = {eng},\n number = {11},\n journal = {{PloS} One},\n author = {Clément, Yan and Le Guisquet, Anne-Marie and Venault, Patrice and Chapouthier, Georges and Belzung, Catherine},\n year = {2009},\n pmid = {19907641},\n pmcid = {PMC2770638},\n keywords = {8-Hydroxy-2-(di-n-propylamino)tetralin, Animals, Anxiety, Behavior, Animal, Benzodiazepines, Bicuculline, Chlordiazepoxide, Female, Indoles, Light, Male, Maze Learning, Mice, Mice, Inbred C57BL, Phosphorylation},\n pages = {e7745}\n}","bibtype":"article","doi":"10.1371/journal.pone.0007745","id":"clement_pharmacological_2009","issn":"1932-6203","journal":"PloS One","key":"clement_pharmacological_2009","keywords":"8-Hydroxy-2-(di-n-propylamino)tetralin, Animals, Anxiety, Behavior, Animal, Benzodiazepines, Bicuculline, Chlordiazepoxide, Female, Indoles, Light, Male, Maze Learning, Mice, Mice, Inbred C57BL, Phosphorylation","language":"eng","number":"11","pages":"e7745","pmcid":"PMC2770638","pmid":"19907641","title":"Pharmacological alterations of anxious behaviour in mice depending on both strain and the behavioural situation","type":"article","volume":"4","year":"2009","bibbaseid":"clment-guisquet-venault-chapouthier-belzung-pharmacologicalalterationsofanxiousbehaviourinmicedependingonbothstrainandthebehaviouralsituation-2009","role":"author","urls":{},"keyword":["8-Hydroxy-2-(di-n-propylamino)tetralin","Animals","Anxiety","Behavior","Animal","Benzodiazepines","Bicuculline","Chlordiazepoxide","Female","Indoles","Light","Male","Maze Learning","Mice","Mice","Inbred C57BL","Phosphorylation"],"downloads":0,"html":""},"bibtype":"article","biburl":"http://bibbase.org/zotero/brizard","creationDate":"2015-02-11T09:04:28.358Z","downloads":0,"keywords":["8-hydroxy-2-(di-n-propylamino)tetralin","animals","anxiety","behavior","animal","benzodiazepines","bicuculline","chlordiazepoxide","female","indoles","light","male","maze learning","mice","mice","inbred c57bl","phosphorylation"],"search_terms":["pharmacological","alterations","anxious","behaviour","mice","depending","both","strain","behavioural","situation","clément","guisquet","venault","chapouthier","belzung"],"title":"Pharmacological alterations of anxious behaviour in mice depending on both strain and the behavioural situation","year":2009,"dataSources":["H9yznXMN7R8ae2jTA"]}