High heritability of antimycobacterial immunity in an area of hyperendemicity for tuberculosis disease. Cobat, A., Gallant, C. J., Simkin, L., Black, G. F., Stanley, K., Hughes, J., Doherty, T. M., Hanekom, W. A., Eley, B., Beyers, N., Jaïs, J., van Helden, P., Abel, L., Hoal, E. G., Alcaïs, A., & Schurr, E. The Journal of Infectious Diseases, 201(1):15–19, January, 2010. 00030 doi abstract bibtex Human antimycobacterial immunity is a critical component of tuberculosis (TB) pathogenesis that is often used to infer the presence of TB infection. We report high heritability (\textgreater50%) for in vitro secretion of tumor necrosis factor alpha and interferon gamma (IFN-gamma), and the frequency of antigen-specific IFN-gamma(+)CD4(+) and IFN-gamma(+)CD8(+) cells in the response of whole blood to mycobacterial challenge. In principal component analysis, the first 3 components explain 78% of the overall variance consistent with the effect of pleiotropic regulatory genes of human antimycobacterial immunity. These results directly demonstrate the pivotal role played by host genetics in quantitative measures of antimycobacterial immunity underlying immune diagnosis of TB infection.
@article{cobat_high_2010,
title = {High heritability of antimycobacterial immunity in an area of hyperendemicity for tuberculosis disease},
volume = {201},
issn = {1537-6613},
doi = {10.1086/648611},
abstract = {Human antimycobacterial immunity is a critical component of tuberculosis (TB) pathogenesis that is often used to infer the presence of TB infection. We report high heritability ({\textgreater}50\%) for in vitro secretion of tumor necrosis factor alpha and interferon gamma (IFN-gamma), and the frequency of antigen-specific IFN-gamma(+)CD4(+) and IFN-gamma(+)CD8(+) cells in the response of whole blood to mycobacterial challenge. In principal component analysis, the first 3 components explain 78\% of the overall variance consistent with the effect of pleiotropic regulatory genes of human antimycobacterial immunity. These results directly demonstrate the pivotal role played by host genetics in quantitative measures of antimycobacterial immunity underlying immune diagnosis of TB infection.},
language = {eng},
number = {1},
journal = {The Journal of Infectious Diseases},
author = {Cobat, Aurelie and Gallant, Caroline J. and Simkin, Leah and Black, Gillian F. and Stanley, Kim and Hughes, Jane and Doherty, T. Mark and Hanekom, Willem A. and Eley, Brian and Beyers, Nulda and Jaïs, Jean-Philippe and van Helden, Paul and Abel, Laurent and Hoal, Eileen G. and Alcaïs, Alexandre and Schurr, Erwin},
month = jan,
year = {2010},
pmid = {19938975},
note = {00030 },
keywords = {Adolescent, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Cells, Cultured, Child, Endemic Diseases, Female, Genotype, Humans, Immunity, Innate, Interferon-gamma, Male, Mycobacterium tuberculosis, Phenotype, Principal Component Analysis, South Africa, Tuberculosis, Tumor Necrosis Factor-alpha, Young Adult},
pages = {15--19},
}
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We report high heritability ({\\textgreater}50\\%) for in vitro secretion of tumor necrosis factor alpha and interferon gamma (IFN-gamma), and the frequency of antigen-specific IFN-gamma(+)CD4(+) and IFN-gamma(+)CD8(+) cells in the response of whole blood to mycobacterial challenge. In principal component analysis, the first 3 components explain 78\\% of the overall variance consistent with the effect of pleiotropic regulatory genes of human antimycobacterial immunity. These results directly demonstrate the pivotal role played by host genetics in quantitative measures of antimycobacterial immunity underlying immune diagnosis of TB infection.},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {The Journal of Infectious Diseases},\n\tauthor = {Cobat, Aurelie and Gallant, Caroline J. and Simkin, Leah and Black, Gillian F. and Stanley, Kim and Hughes, Jane and Doherty, T. 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