@article{coghill_neuropsychological_2007,
	title = {The neuropsychological effects of chronic methylphenidate on drug-naive boys with attention-deficit/hyperactivity disorder},
	volume = {62},
	url = {http://dx.doi.org/10.1016/j.biopsych.2006.12.030},
	abstract = {BACKGROUND: The reported neuropsychological effects of methylphenidate (MPH) in attention-deficit/hyperactivity disorder (ADHD) are inconsistent. The assumed relationships between these neuropsychological effects and clinical efficacy have not been substantiated. We therefore investigated the effects of chronic MPH administration on neuropsychological functioning. METHODS: We conducted a 12-week, placebo-controlled, double-blinded, randomized, crossover trial (MPH .3 and .6 mg/kg/dose and placebo). Participants were 75 boys aged 7-15 years with ADHD. Neuropsychological performance was assessed with tests taken from the Cambridge Neuropsychological Test Automated Battery (CANTAB) battery and a GoNoGo task. RESULTS: Chronic MPH improved performance (p .05). GoNoGo performance improvements were the only neuropsychopharmacological changes associated with clinical response. Poor performance on the DMtS task was the sole baseline neuropsychological predictor of clinical response. CONCLUSIONS: Chronic MPH predominantly enhanced neuropsychological functioning on "recognition memory" component tasks with modest "executive" demands. Neuropsychological measures offer only modest contributions to the prediction of clinical responses to MPH in ADHD.},
	number = {9},
	journal = {Biological Psychiatry},
	author = {Coghill, David R and Rhodes, Sinéad M and Matthews, Keith},
	year = {2007},
	note = {Publisher: Section of Psychiatry and Behavioral Sciences, Division of Pathology and Neuroscience, University of Dundee, Ninewells Medical School, Dundee, United Kingdom. d.r.coghill@dundee.ac.uk},
	keywords = {adolescent, association learning, association learning drug effects, attention deficit disorder with hyperactivity, attention deficit disorder with hyperactivity dru, attention deficit disorder with hyperactivity phy, central nervous system stimulants, central nervous system stimulants administration, child, choice behavior, choice behavior drug effects, cross over studies, dose response relationship, double blind method, drug, drug administration routes, humans, male, methylphenidate, methylphenidate administration \& dosage, neuropsychological tests, neuropsychological tests statistics \& numerical d, predictive value tests, principal component analysis, problem solving, problem solving drug effects, reaction time, reaction time drug effects, recognition (psychology), recognition (psychology) drug effects, time factors},
	pages = {954--962},
}

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METHODS: We conducted a 12-week, placebo-controlled, double-blinded, randomized, crossover trial (MPH .3 and .6 mg/kg/dose and placebo). Participants were 75 boys aged 7-15 years with ADHD. Neuropsychological performance was assessed with tests taken from the Cambridge Neuropsychological Test Automated Battery (CANTAB) battery and a GoNoGo task. RESULTS: Chronic MPH improved performance (p .05). GoNoGo performance improvements were the only neuropsychopharmacological changes associated with clinical response. Poor performance on the DMtS task was the sole baseline neuropsychological predictor of clinical response. CONCLUSIONS: Chronic MPH predominantly enhanced neuropsychological functioning on \"recognition memory\" component tasks with modest \"executive\" demands. Neuropsychological measures offer only modest contributions to the prediction of clinical responses to MPH in ADHD.","number":"9","journal":"Biological Psychiatry","author":[{"propositions":[],"lastnames":["Coghill"],"firstnames":["David","R"],"suffixes":[]},{"propositions":[],"lastnames":["Rhodes"],"firstnames":["Sinéad","M"],"suffixes":[]},{"propositions":[],"lastnames":["Matthews"],"firstnames":["Keith"],"suffixes":[]}],"year":"2007","note":"Publisher: Section of Psychiatry and Behavioral Sciences, Division of Pathology and Neuroscience, University of Dundee, Ninewells Medical School, Dundee, United Kingdom. d.r.coghill@dundee.ac.uk","keywords":"adolescent, association learning, association learning drug effects, attention deficit disorder with hyperactivity, attention deficit disorder with hyperactivity dru, attention deficit disorder with hyperactivity phy, central nervous system stimulants, central nervous system stimulants administration, child, choice behavior, choice behavior drug effects, cross over studies, dose response relationship, double blind method, drug, drug administration routes, humans, male, methylphenidate, methylphenidate administration & dosage, neuropsychological tests, neuropsychological tests statistics & numerical d, predictive value tests, principal component analysis, problem solving, problem solving drug effects, reaction time, reaction time drug effects, recognition (psychology), recognition (psychology) drug effects, time factors","pages":"954–962","bibtex":"@article{coghill_neuropsychological_2007,\n\ttitle = {The neuropsychological effects of chronic methylphenidate on drug-naive boys with attention-deficit/hyperactivity disorder},\n\tvolume = {62},\n\turl = {http://dx.doi.org/10.1016/j.biopsych.2006.12.030},\n\tabstract = {BACKGROUND: The reported neuropsychological effects of methylphenidate (MPH) in attention-deficit/hyperactivity disorder (ADHD) are inconsistent. The assumed relationships between these neuropsychological effects and clinical efficacy have not been substantiated. We therefore investigated the effects of chronic MPH administration on neuropsychological functioning. METHODS: We conducted a 12-week, placebo-controlled, double-blinded, randomized, crossover trial (MPH .3 and .6 mg/kg/dose and placebo). Participants were 75 boys aged 7-15 years with ADHD. Neuropsychological performance was assessed with tests taken from the Cambridge Neuropsychological Test Automated Battery (CANTAB) battery and a GoNoGo task. RESULTS: Chronic MPH improved performance (p .05). GoNoGo performance improvements were the only neuropsychopharmacological changes associated with clinical response. Poor performance on the DMtS task was the sole baseline neuropsychological predictor of clinical response. CONCLUSIONS: Chronic MPH predominantly enhanced neuropsychological functioning on \"recognition memory\" component tasks with modest \"executive\" demands. Neuropsychological measures offer only modest contributions to the prediction of clinical responses to MPH in ADHD.},\n\tnumber = {9},\n\tjournal = {Biological Psychiatry},\n\tauthor = {Coghill, David R and Rhodes, Sinéad M and Matthews, Keith},\n\tyear = {2007},\n\tnote = {Publisher: Section of Psychiatry and Behavioral Sciences, Division of Pathology and Neuroscience, University of Dundee, Ninewells Medical School, Dundee, United Kingdom. d.r.coghill@dundee.ac.uk},\n\tkeywords = {adolescent, association learning, association learning drug effects, attention deficit disorder with hyperactivity, attention deficit disorder with hyperactivity dru, attention deficit disorder with hyperactivity phy, central nervous system stimulants, central nervous system stimulants administration, child, choice behavior, choice behavior drug effects, cross over studies, dose response relationship, double blind method, drug, drug administration routes, humans, male, methylphenidate, methylphenidate administration \\& dosage, neuropsychological tests, neuropsychological tests statistics \\& numerical d, predictive value tests, principal component analysis, problem solving, problem solving drug effects, reaction time, reaction time drug effects, recognition (psychology), recognition (psychology) drug effects, time factors},\n\tpages = {954--962},\n}\n\n","author_short":["Coghill, D. 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