@article{coito2019epi,
   author = {Coito, A. and Biethahn, S. and Tepperberg, J. and Carboni, M. and Roelcke, U. and Seeck, M. and van Mierlo, P. and Gschwind, M. and Vulliemoz, S.},
   title = {Interictal epileptogenic zone localization in patients with focal epilepsy using electric source imaging and directed functional connectivity from low-density EEG},
   journal = {Epilepsia Open},
   volume = {4},
   number = {2},
   pages = {281-292},
   abstract = {Objective: Electrical source imaging (ESI) is used increasingly to estimate the epileptogenic zone (EZ) in patients with epilepsy. Directed functional connectivity (DFC) coupled to ESI helps to better characterize epileptic networks, but studies on interictal activity have relied on high-density recordings. We investigated the accuracy of ESI and DFC for localizing the EZ, based on low-density clinical electroencephalography (EEG). Methods: We selected patients with the following: (a) focal epilepsy, (b) interictal spikes on standard EEG, (c) either a focal structural lesion concordant with the electroclinical semiology or good postoperative outcome. In 34 patients (20 temporal lobe epilepsy [TLE], 14 extra-TLE [ETLE]), we marked interictal spikes and estimated the cortical activity during each spike in 82 cortical regions using a patient-specific head model and distributed linear inverse solution. DFC between brain regions was computed using Granger-causal modeling followed by network topologic measures. The concordance with the presumed EZ at the sublobar level was computed using the epileptogenic lesion or the resected area in postoperative seizure-free patients. Results: ESI, summed outflow, and efficiency were concordant with the presumed EZ in 76% of the patients, whereas the clustering coefficient and betweenness centrality were concordant in 70% of patients. There was no significant difference between ESI and connectivity measures. In all measures, patients with TLE had a significantly higher (P < 0.05) concordance with the presumed EZ than patients with with ETLE. The brain volume accepted for concordance was significantly larger in TLE. Significance: ESI and DFC derived from low-density EEG can reliably estimate the EZ from interictal spikes. Connectivity measures were not superior to ESI for EZ localization during interictal spikes, but the current validation of the localization of connectivity measure is promising for other applications.},
   issn = {2470-9239},
   doi = {10.1002/epi4.12318},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/31168495},
   year = {2019}
}

{"_id":"yMPPYTyEtMJCNZy8W","bibbaseid":"coito-biethahn-tepperberg-carboni-roelcke-seeck-vanmierlo-gschwind-etal-interictalepileptogeniczonelocalizationinpatientswithfocalepilepsyusingelectricsourceimaginganddirectedfunctionalconnectivityfromlowdensityeeg-2019","authorIDs":[],"author_short":["Coito, A.","Biethahn, S.","Tepperberg, J.","Carboni, M.","Roelcke, U.","Seeck, M.","van Mierlo, P.","Gschwind, M.","Vulliemoz, S."],"bibdata":{"bibtype":"article","type":"article","author":[{"propositions":[],"lastnames":["Coito"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Biethahn"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Tepperberg"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Carboni"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Roelcke"],"firstnames":["U."],"suffixes":[]},{"propositions":[],"lastnames":["Seeck"],"firstnames":["M."],"suffixes":[]},{"propositions":["van"],"lastnames":["Mierlo"],"firstnames":["P."],"suffixes":[]},{"propositions":[],"lastnames":["Gschwind"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Vulliemoz"],"firstnames":["S."],"suffixes":[]}],"title":"Interictal epileptogenic zone localization in patients with focal epilepsy using electric source imaging and directed functional connectivity from low-density EEG","journal":"Epilepsia Open","volume":"4","number":"2","pages":"281-292","abstract":"Objective: Electrical source imaging (ESI) is used increasingly to estimate the epileptogenic zone (EZ) in patients with epilepsy. Directed functional connectivity (DFC) coupled to ESI helps to better characterize epileptic networks, but studies on interictal activity have relied on high-density recordings. We investigated the accuracy of ESI and DFC for localizing the EZ, based on low-density clinical electroencephalography (EEG). Methods: We selected patients with the following: (a) focal epilepsy, (b) interictal spikes on standard EEG, (c) either a focal structural lesion concordant with the electroclinical semiology or good postoperative outcome. In 34 patients (20 temporal lobe epilepsy [TLE], 14 extra-TLE [ETLE]), we marked interictal spikes and estimated the cortical activity during each spike in 82 cortical regions using a patient-specific head model and distributed linear inverse solution. DFC between brain regions was computed using Granger-causal modeling followed by network topologic measures. The concordance with the presumed EZ at the sublobar level was computed using the epileptogenic lesion or the resected area in postoperative seizure-free patients. Results: ESI, summed outflow, and efficiency were concordant with the presumed EZ in 76% of the patients, whereas the clustering coefficient and betweenness centrality were concordant in 70% of patients. There was no significant difference between ESI and connectivity measures. In all measures, patients with TLE had a significantly higher (P < 0.05) concordance with the presumed EZ than patients with with ETLE. The brain volume accepted for concordance was significantly larger in TLE. Significance: ESI and DFC derived from low-density EEG can reliably estimate the EZ from interictal spikes. Connectivity measures were not superior to ESI for EZ localization during interictal spikes, but the current validation of the localization of connectivity measure is promising for other applications.","issn":"2470-9239","doi":"10.1002/epi4.12318","url":"http://www.ncbi.nlm.nih.gov/pubmed/31168495","year":"2019","bibtex":"@article{coito2019epi,\n author = {Coito, A. and Biethahn, S. and Tepperberg, J. and Carboni, M. and Roelcke, U. and Seeck, M. and van Mierlo, P. and Gschwind, M. and Vulliemoz, S.},\n title = {Interictal epileptogenic zone localization in patients with focal epilepsy using electric source imaging and directed functional connectivity from low-density EEG},\n journal = {Epilepsia Open},\n volume = {4},\n number = {2},\n pages = {281-292},\n abstract = {Objective: Electrical source imaging (ESI) is used increasingly to estimate the epileptogenic zone (EZ) in patients with epilepsy. Directed functional connectivity (DFC) coupled to ESI helps to better characterize epileptic networks, but studies on interictal activity have relied on high-density recordings. We investigated the accuracy of ESI and DFC for localizing the EZ, based on low-density clinical electroencephalography (EEG). Methods: We selected patients with the following: (a) focal epilepsy, (b) interictal spikes on standard EEG, (c) either a focal structural lesion concordant with the electroclinical semiology or good postoperative outcome. In 34 patients (20 temporal lobe epilepsy [TLE], 14 extra-TLE [ETLE]), we marked interictal spikes and estimated the cortical activity during each spike in 82 cortical regions using a patient-specific head model and distributed linear inverse solution. DFC between brain regions was computed using Granger-causal modeling followed by network topologic measures. The concordance with the presumed EZ at the sublobar level was computed using the epileptogenic lesion or the resected area in postoperative seizure-free patients. Results: ESI, summed outflow, and efficiency were concordant with the presumed EZ in 76% of the patients, whereas the clustering coefficient and betweenness centrality were concordant in 70% of patients. There was no significant difference between ESI and connectivity measures. In all measures, patients with TLE had a significantly higher (P < 0.05) concordance with the presumed EZ than patients with with ETLE. The brain volume accepted for concordance was significantly larger in TLE. Significance: ESI and DFC derived from low-density EEG can reliably estimate the EZ from interictal spikes. Connectivity measures were not superior to ESI for EZ localization during interictal spikes, but the current validation of the localization of connectivity measure is promising for other applications.},\n issn = {2470-9239},\n doi = {10.1002/epi4.12318},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/31168495},\n year = {2019}\n}\n\n","author_short":["Coito, A.","Biethahn, S.","Tepperberg, J.","Carboni, M.","Roelcke, U.","Seeck, M.","van Mierlo, P.","Gschwind, M.","Vulliemoz, S."],"key":"coito2019epi","id":"coito2019epi","bibbaseid":"coito-biethahn-tepperberg-carboni-roelcke-seeck-vanmierlo-gschwind-etal-interictalepileptogeniczonelocalizationinpatientswithfocalepilepsyusingelectricsourceimaginganddirectedfunctionalconnectivityfromlowdensityeeg-2019","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/31168495"},"metadata":{"authorlinks":{}},"downloads":1,"html":""},"bibtype":"article","biburl":"https://sinergiaconsortium.bitbucket.io/resources/bibtex/publications.bib","creationDate":"2019-10-18T11:08:25.295Z","downloads":1,"keywords":[],"search_terms":["interictal","epileptogenic","zone","localization","patients","focal","epilepsy","using","electric","source","imaging","directed","functional","connectivity","low","density","eeg","coito","biethahn","tepperberg","carboni","roelcke","seeck","van mierlo","gschwind","vulliemoz"],"title":"Interictal epileptogenic zone localization in patients with focal epilepsy using electric source imaging and directed functional connectivity from low-density EEG","year":2019,"dataSources":["wEGX6SMfTj4mEEPK9"]}