@article{cojoc_effects_2006,
	title = {Effects of single-site versus biventricular epicardial pacing on myocardial performance in an immature animal model of atrioventricular block.},
	volume = {17},
	issn = {1045-3873},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/16903967},
	doi = {10.1111/j.1540-8167.2006.00504.x},
	abstract = {INTRODUCTION: Single-site ventricular pacing results in dyssynchronous ventricular activation and may contribute to ventricular dysfunction. We evaluated epicardial biventricular (BiV) pacing as a means of maintaining synchronous ventricular activation in an acute piglet model of AV block with normal ventricular anatomy and function. METHODS AND RESULTS: We used left ventricular (LV) impedance catheters and tissue Doppler imaging to assess the cardiodynamics of immature piglets (n = 6, 33-78 days, 9.35 +/- 0.85 kg). Following catheter ablation of the AV node, a pacemaker was programmed 20 beats per minute above the intrinsic atrial rate. The animals were paced at 5-minute intervals via the following AV sequential configurations: Right atrial appendage (RA)-RV apex (RVA), RA-LV apex (LVA), and RA-biventricular (RVA/LVA). RA-RVA was the experimental control. LV systolic mechanics, measured by the slope of the end-systolic pressure-volume relationship (E(es)), increased with BiV pacing (12.8 +/- 3.4 mmHg/mL, P {\textless} 0.02) or single-site LVA pacing (10.6 +/- 3.4 mmHg/mL, P {\textless} 0.05) compared with single-site RVA pacing (8.3 +/- 1.4 mmHg/mL). QRS duration lengthened compared with sinus rhythm (42 +/- 8 msec) with either RVA (56 +/- 9 msec, P {\textless} 0.02) or LVA (54 +/- 7 msec, P {\textless} 0.03), but not with BiV (48 +/- 7 msec, P = 0.08) pacing. Tissue Doppler imaging showed LV dyssynchrony with RVA (septal-to-lateral delay 46.0 +/- 51.7 msec), with return toward normal with LVA (-9.6 +/- 33.6 msec, P {\textless} 0.04) or BiV (-4.1 +/- 33.8 msec, P {\textless} 0.04) pacing. CONCLUSIONS: In this acute immature piglet model of AV block, LV performance improved with single-site pacing from the LVA and BiV pacing (RVA/LVA), as compared with single-site pacing from the RVA. These changes correlated with tissue Doppler indices of mechanical synchrony, though not necessarily with QRS duration.},
	language = {eng},
	number = {8},
	journal = {J Cardiovasc Electrophysiol},
	author = {Cojoc, A and Reeves, JG and Schmarkey, L and Strieper, MJ and Joyner, RW and Wagner, MB and Campbell, RM and Vinten-Johansen, J and Frias, PA},
	month = aug,
	year = {2006},
	keywords = {Left, Ventricular Function},
	pages = {884--889}
}

{"_id":"SYHtMM8u46q3ZE6dt","bibbaseid":"cojoc-reeves-schmarkey-strieper-joyner-wagner-campbell-vintenjohansen-etal-effectsofsinglesiteversusbiventricularepicardialpacingonmyocardialperformanceinanimmatureanimalmodelofatrioventricularblock-2006","downloads":0,"creationDate":"2019-02-05T17:54:52.520Z","title":"Effects of single-site versus biventricular epicardial pacing on myocardial performance in an immature animal model of atrioventricular block.","author_short":["Cojoc, A","Reeves, J.","Schmarkey, L","Strieper, M.","Joyner, R.","Wagner, M.","Campbell, R.","Vinten-Johansen, J","Frias, P."],"year":2006,"bibtype":"article","biburl":"https://bibbase.org/zotero/krpowel1","bibdata":{"bibtype":"article","type":"article","title":"Effects of single-site versus biventricular epicardial pacing on myocardial performance in an immature animal model of atrioventricular block.","volume":"17","issn":"1045-3873","url":"https://www.ncbi.nlm.nih.gov/pubmed/16903967","doi":"10.1111/j.1540-8167.2006.00504.x","abstract":"INTRODUCTION: Single-site ventricular pacing results in dyssynchronous ventricular activation and may contribute to ventricular dysfunction. We evaluated epicardial biventricular (BiV) pacing as a means of maintaining synchronous ventricular activation in an acute piglet model of AV block with normal ventricular anatomy and function. METHODS AND RESULTS: We used left ventricular (LV) impedance catheters and tissue Doppler imaging to assess the cardiodynamics of immature piglets (n = 6, 33-78 days, 9.35 +/- 0.85 kg). Following catheter ablation of the AV node, a pacemaker was programmed 20 beats per minute above the intrinsic atrial rate. The animals were paced at 5-minute intervals via the following AV sequential configurations: Right atrial appendage (RA)-RV apex (RVA), RA-LV apex (LVA), and RA-biventricular (RVA/LVA). RA-RVA was the experimental control. LV systolic mechanics, measured by the slope of the end-systolic pressure-volume relationship (E(es)), increased with BiV pacing (12.8 +/- 3.4 mmHg/mL, P \\textless 0.02) or single-site LVA pacing (10.6 +/- 3.4 mmHg/mL, P \\textless 0.05) compared with single-site RVA pacing (8.3 +/- 1.4 mmHg/mL). QRS duration lengthened compared with sinus rhythm (42 +/- 8 msec) with either RVA (56 +/- 9 msec, P \\textless 0.02) or LVA (54 +/- 7 msec, P \\textless 0.03), but not with BiV (48 +/- 7 msec, P = 0.08) pacing. Tissue Doppler imaging showed LV dyssynchrony with RVA (septal-to-lateral delay 46.0 +/- 51.7 msec), with return toward normal with LVA (-9.6 +/- 33.6 msec, P \\textless 0.04) or BiV (-4.1 +/- 33.8 msec, P \\textless 0.04) pacing. CONCLUSIONS: In this acute immature piglet model of AV block, LV performance improved with single-site pacing from the LVA and BiV pacing (RVA/LVA), as compared with single-site pacing from the RVA. These changes correlated with tissue Doppler indices of mechanical synchrony, though not necessarily with QRS duration.","language":"eng","number":"8","journal":"J Cardiovasc Electrophysiol","author":[{"propositions":[],"lastnames":["Cojoc"],"firstnames":["A"],"suffixes":[]},{"propositions":[],"lastnames":["Reeves"],"firstnames":["JG"],"suffixes":[]},{"propositions":[],"lastnames":["Schmarkey"],"firstnames":["L"],"suffixes":[]},{"propositions":[],"lastnames":["Strieper"],"firstnames":["MJ"],"suffixes":[]},{"propositions":[],"lastnames":["Joyner"],"firstnames":["RW"],"suffixes":[]},{"propositions":[],"lastnames":["Wagner"],"firstnames":["MB"],"suffixes":[]},{"propositions":[],"lastnames":["Campbell"],"firstnames":["RM"],"suffixes":[]},{"propositions":[],"lastnames":["Vinten-Johansen"],"firstnames":["J"],"suffixes":[]},{"propositions":[],"lastnames":["Frias"],"firstnames":["PA"],"suffixes":[]}],"month":"August","year":"2006","keywords":"Left, Ventricular Function","pages":"884–889","bibtex":"@article{cojoc_effects_2006,\n\ttitle = {Effects of single-site versus biventricular epicardial pacing on myocardial performance in an immature animal model of atrioventricular block.},\n\tvolume = {17},\n\tissn = {1045-3873},\n\turl = {https://www.ncbi.nlm.nih.gov/pubmed/16903967},\n\tdoi = {10.1111/j.1540-8167.2006.00504.x},\n\tabstract = {INTRODUCTION: Single-site ventricular pacing results in dyssynchronous ventricular activation and may contribute to ventricular dysfunction. We evaluated epicardial biventricular (BiV) pacing as a means of maintaining synchronous ventricular activation in an acute piglet model of AV block with normal ventricular anatomy and function. METHODS AND RESULTS: We used left ventricular (LV) impedance catheters and tissue Doppler imaging to assess the cardiodynamics of immature piglets (n = 6, 33-78 days, 9.35 +/- 0.85 kg). Following catheter ablation of the AV node, a pacemaker was programmed 20 beats per minute above the intrinsic atrial rate. The animals were paced at 5-minute intervals via the following AV sequential configurations: Right atrial appendage (RA)-RV apex (RVA), RA-LV apex (LVA), and RA-biventricular (RVA/LVA). RA-RVA was the experimental control. LV systolic mechanics, measured by the slope of the end-systolic pressure-volume relationship (E(es)), increased with BiV pacing (12.8 +/- 3.4 mmHg/mL, P {\\textless} 0.02) or single-site LVA pacing (10.6 +/- 3.4 mmHg/mL, P {\\textless} 0.05) compared with single-site RVA pacing (8.3 +/- 1.4 mmHg/mL). QRS duration lengthened compared with sinus rhythm (42 +/- 8 msec) with either RVA (56 +/- 9 msec, P {\\textless} 0.02) or LVA (54 +/- 7 msec, P {\\textless} 0.03), but not with BiV (48 +/- 7 msec, P = 0.08) pacing. Tissue Doppler imaging showed LV dyssynchrony with RVA (septal-to-lateral delay 46.0 +/- 51.7 msec), with return toward normal with LVA (-9.6 +/- 33.6 msec, P {\\textless} 0.04) or BiV (-4.1 +/- 33.8 msec, P {\\textless} 0.04) pacing. CONCLUSIONS: In this acute immature piglet model of AV block, LV performance improved with single-site pacing from the LVA and BiV pacing (RVA/LVA), as compared with single-site pacing from the RVA. These changes correlated with tissue Doppler indices of mechanical synchrony, though not necessarily with QRS duration.},\n\tlanguage = {eng},\n\tnumber = {8},\n\tjournal = {J Cardiovasc Electrophysiol},\n\tauthor = {Cojoc, A and Reeves, JG and Schmarkey, L and Strieper, MJ and Joyner, RW and Wagner, MB and Campbell, RM and Vinten-Johansen, J and Frias, PA},\n\tmonth = aug,\n\tyear = {2006},\n\tkeywords = {Left, Ventricular Function},\n\tpages = {884--889}\n}\n\n","author_short":["Cojoc, A","Reeves, J.","Schmarkey, L","Strieper, M.","Joyner, R.","Wagner, M.","Campbell, R.","Vinten-Johansen, J","Frias, P."],"key":"cojoc_effects_2006","id":"cojoc_effects_2006","bibbaseid":"cojoc-reeves-schmarkey-strieper-joyner-wagner-campbell-vintenjohansen-etal-effectsofsinglesiteversusbiventricularepicardialpacingonmyocardialperformanceinanimmatureanimalmodelofatrioventricularblock-2006","role":"author","urls":{"Paper":"https://www.ncbi.nlm.nih.gov/pubmed/16903967"},"keyword":["Left","Ventricular Function"],"downloads":0},"search_terms":["effects","single","site","versus","biventricular","epicardial","pacing","myocardial","performance","immature","animal","model","atrioventricular","block","cojoc","reeves","schmarkey","strieper","joyner","wagner","campbell","vinten-johansen","frias"],"keywords":["left","ventricular function"],"authorIDs":[],"dataSources":["RWfJMkk8dvE5SSfWn"]}