@article{RN137,
   author = {Colon, A. J. and Hofman, P. and Ossenblok, P. P. and Jansen, J. F. and Ter Beek, L. C. and Berting, R. and Stam, C. J. and Boon, P.},
   title = {MRS-lateralisation index in patients with epilepsy and focal cortical dysplasia or a MEG-focus using bilateral single voxels},
   journal = {Epilepsy Res},
   volume = {89},
   number = {1},
   pages = {148-53},
   note = {Colon, A J
Hofman, P
Ossenblok, P P W
Jansen, J F A
Ter Beek, L C
Berting, R
Stam, C J
Boon, P
eng
Research Support, Non-U.S. Gov't
Netherlands
2009/12/22 06:00
Epilepsy Res. 2010 Mar;89(1):148-53. doi: 10.1016/j.eplepsyres.2009.11.007. Epub 2009 Dec 21.},
   abstract = {PURPOSE: To evaluate if single voxel proton magnetic resonance spectroscopy (SV-MRS) can help in lateralising and sometimes in localizing an epileptogenic focus. The assumption is that in MRI negative patients the underlying pathology most often is focal cortical dysplasia (FCD). Several studies have shown that in the presence of FCD there are also (1)H-MRS abnormalities on the contralateral side. However, in most cases the studied group was not homogeneous and included different forms of dysplasias, including band heterotopias and polymicrogyria, and the studies used different spectroscopy protocols. In the present study, using bilateral SV-MRS we investigated the presence of a lateralisation index in two groups of patients with localisation related epilepsy: patients with focal cortical dysplasia on MRI and patients without MRI abnormalities with a focus identified by MEG. Aim of the study was to show that in both groups the expected epileptogenic side shows more pronounced metabolic alterations, making MRS a possible screening tool for clarifying lateralisation questions in patients with cryptogenic localisation related epilepsy. METHODS: In ten patients a single voxel was placed over the FCD and in nine patients over the region of interest (ROI) as indicated by MEG. In all patients a voxel was also placed in the contralateral homologus location. We used metabolite concentrations as peak ratios relative to the creatine (Cr) peak to calculate a lateralisation index. RESULTS: In both groups NAA/Cr was significantly lower on the affected side whereas the results for Cho/Cr were more diverse. There were no significant differences between the two groups. The limitations of the used methods and the implications of the findings are discussed.},
   keywords = {Adult
Aged
Brain/*physiopathology
Brain Mapping/*methods
Diagnosis, Differential
Epilepsy/*diagnosis/physiopathology
Female
Functional Laterality/*physiology
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Magnetoencephalography
Male
Malformations of Cortical Development/*diagnosis/physiopathology
Middle Aged},
   ISSN = {1872-6844 (Electronic)
0920-1211 (Linking)},
   DOI = {10.1016/j.eplepsyres.2009.11.007},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/20022471
https://www.sciencedirect.com/science/article/abs/pii/S0920121109003477?via%3Dihub},
   year = {2010},
   type = {Journal Article}
}

{"_id":"iSmwt7PM5HG3TzLmz","bibbaseid":"colon-hofman-ossenblok-jansen-terbeek-berting-stam-boon-mrslateralisationindexinpatientswithepilepsyandfocalcorticaldysplasiaoramegfocususingbilateralsinglevoxels-2010","downloads":0,"creationDate":"2017-09-02T18:10:13.562Z","title":"MRS-lateralisation index in patients with epilepsy and focal cortical dysplasia or a MEG-focus using bilateral single voxels","author_short":["Colon, A. J.","Hofman, P.","Ossenblok, P. P.","Jansen, J. F.","Ter Beek, L. C.","Berting, R.","Stam, C. J.","Boon, P."],"year":2010,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Colon"],"firstnames":["A.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Hofman"],"firstnames":["P."],"suffixes":[]},{"propositions":[],"lastnames":["Ossenblok"],"firstnames":["P.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F."],"suffixes":[]},{"propositions":[],"lastnames":["Ter","Beek"],"firstnames":["L.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Berting"],"firstnames":["R."],"suffixes":[]},{"propositions":[],"lastnames":["Stam"],"firstnames":["C.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Boon"],"firstnames":["P."],"suffixes":[]}],"title":"MRS-lateralisation index in patients with epilepsy and focal cortical dysplasia or a MEG-focus using bilateral single voxels","journal":"Epilepsy Res","volume":"89","number":"1","pages":"148-53","note":"Colon, A J Hofman, P Ossenblok, P P W Jansen, J F A Ter Beek, L C Berting, R Stam, C J Boon, P eng Research Support, Non-U.S. Gov't Netherlands 2009/12/22 06:00 Epilepsy Res. 2010 Mar;89(1):148-53. doi: 10.1016/j.eplepsyres.2009.11.007. Epub 2009 Dec 21.","abstract":"PURPOSE: To evaluate if single voxel proton magnetic resonance spectroscopy (SV-MRS) can help in lateralising and sometimes in localizing an epileptogenic focus. The assumption is that in MRI negative patients the underlying pathology most often is focal cortical dysplasia (FCD). Several studies have shown that in the presence of FCD there are also (1)H-MRS abnormalities on the contralateral side. However, in most cases the studied group was not homogeneous and included different forms of dysplasias, including band heterotopias and polymicrogyria, and the studies used different spectroscopy protocols. In the present study, using bilateral SV-MRS we investigated the presence of a lateralisation index in two groups of patients with localisation related epilepsy: patients with focal cortical dysplasia on MRI and patients without MRI abnormalities with a focus identified by MEG. Aim of the study was to show that in both groups the expected epileptogenic side shows more pronounced metabolic alterations, making MRS a possible screening tool for clarifying lateralisation questions in patients with cryptogenic localisation related epilepsy. METHODS: In ten patients a single voxel was placed over the FCD and in nine patients over the region of interest (ROI) as indicated by MEG. In all patients a voxel was also placed in the contralateral homologus location. We used metabolite concentrations as peak ratios relative to the creatine (Cr) peak to calculate a lateralisation index. RESULTS: In both groups NAA/Cr was significantly lower on the affected side whereas the results for Cho/Cr were more diverse. There were no significant differences between the two groups. The limitations of the used methods and the implications of the findings are discussed.","keywords":"Adult Aged Brain/*physiopathology Brain Mapping/*methods Diagnosis, Differential Epilepsy/*diagnosis/physiopathology Female Functional Laterality/*physiology Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Magnetoencephalography Male Malformations of Cortical Development/*diagnosis/physiopathology Middle Aged","issn":"1872-6844 (Electronic) 0920-1211 (Linking)","doi":"10.1016/j.eplepsyres.2009.11.007","url":"http://www.ncbi.nlm.nih.gov/pubmed/20022471 https://www.sciencedirect.com/science/article/abs/pii/S0920121109003477?via%3Dihub","year":"2010","bibtex":"@article{RN137,\n author = {Colon, A. J. and Hofman, P. and Ossenblok, P. P. and Jansen, J. F. and Ter Beek, L. C. and Berting, R. and Stam, C. J. and Boon, P.},\n title = {MRS-lateralisation index in patients with epilepsy and focal cortical dysplasia or a MEG-focus using bilateral single voxels},\n journal = {Epilepsy Res},\n volume = {89},\n number = {1},\n pages = {148-53},\n note = {Colon, A J\nHofman, P\nOssenblok, P P W\nJansen, J F A\nTer Beek, L C\nBerting, R\nStam, C J\nBoon, P\neng\nResearch Support, Non-U.S. Gov't\nNetherlands\n2009/12/22 06:00\nEpilepsy Res. 2010 Mar;89(1):148-53. doi: 10.1016/j.eplepsyres.2009.11.007. Epub 2009 Dec 21.},\n abstract = {PURPOSE: To evaluate if single voxel proton magnetic resonance spectroscopy (SV-MRS) can help in lateralising and sometimes in localizing an epileptogenic focus. The assumption is that in MRI negative patients the underlying pathology most often is focal cortical dysplasia (FCD). Several studies have shown that in the presence of FCD there are also (1)H-MRS abnormalities on the contralateral side. However, in most cases the studied group was not homogeneous and included different forms of dysplasias, including band heterotopias and polymicrogyria, and the studies used different spectroscopy protocols. In the present study, using bilateral SV-MRS we investigated the presence of a lateralisation index in two groups of patients with localisation related epilepsy: patients with focal cortical dysplasia on MRI and patients without MRI abnormalities with a focus identified by MEG. Aim of the study was to show that in both groups the expected epileptogenic side shows more pronounced metabolic alterations, making MRS a possible screening tool for clarifying lateralisation questions in patients with cryptogenic localisation related epilepsy. METHODS: In ten patients a single voxel was placed over the FCD and in nine patients over the region of interest (ROI) as indicated by MEG. In all patients a voxel was also placed in the contralateral homologus location. We used metabolite concentrations as peak ratios relative to the creatine (Cr) peak to calculate a lateralisation index. RESULTS: In both groups NAA/Cr was significantly lower on the affected side whereas the results for Cho/Cr were more diverse. There were no significant differences between the two groups. The limitations of the used methods and the implications of the findings are discussed.},\n keywords = {Adult\nAged\nBrain/*physiopathology\nBrain Mapping/*methods\nDiagnosis, Differential\nEpilepsy/*diagnosis/physiopathology\nFemale\nFunctional Laterality/*physiology\nHumans\nImage Processing, Computer-Assisted\nMagnetic Resonance Imaging\nMagnetic Resonance Spectroscopy\nMagnetoencephalography\nMale\nMalformations of Cortical Development/*diagnosis/physiopathology\nMiddle Aged},\n ISSN = {1872-6844 (Electronic)\n0920-1211 (Linking)},\n DOI = {10.1016/j.eplepsyres.2009.11.007},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/20022471\nhttps://www.sciencedirect.com/science/article/abs/pii/S0920121109003477?via%3Dihub},\n year = {2010},\n type = {Journal Article}\n}\n\n","author_short":["Colon, A. J.","Hofman, P.","Ossenblok, P. P.","Jansen, J. F.","Ter Beek, L. C.","Berting, R.","Stam, C. J.","Boon, P."],"key":"RN137","id":"RN137","bibbaseid":"colon-hofman-ossenblok-jansen-terbeek-berting-stam-boon-mrslateralisationindexinpatientswithepilepsyandfocalcorticaldysplasiaoramegfocususingbilateralsinglevoxels-2010","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/20022471 https://www.sciencedirect.com/science/article/abs/pii/S0920121109003477?via%3Dihub"},"keyword":["Adult Aged Brain/*physiopathology Brain Mapping/*methods Diagnosis","Differential Epilepsy/*diagnosis/physiopathology Female Functional Laterality/*physiology Humans Image Processing","Computer-Assisted Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Magnetoencephalography Male Malformations of Cortical Development/*diagnosis/physiopathology Middle Aged"],"metadata":{"authorlinks":{"jansen, j":"https://www.jansenjfa.com/publications/"}},"downloads":0,"html":""},"search_terms":["mrs","lateralisation","index","patients","epilepsy","focal","cortical","dysplasia","meg","focus","using","bilateral","single","voxels","colon","hofman","ossenblok","jansen","ter beek","berting","stam","boon"],"keywords":["adult aged brain/*physiopathology brain mapping/*methods diagnosis","differential epilepsy/*diagnosis/physiopathology female functional laterality/*physiology humans image processing","computer-assisted magnetic resonance imaging magnetic resonance spectroscopy magnetoencephalography male malformations of cortical development/*diagnosis/physiopathology middle aged"],"authorIDs":["59aae01e5ead235c6f00001d","5df1707557cfb4de0100001d","5e024e386ffa15df0100007a","5e47cbe8af70c7de0100001a","5e4ea88f64b624de01000110","5e685fc7149172de01000144","9uYiZAT4SGYEdwuhG","CHX5tw5dNmS7tFMt9","DoNKbgB55xkR6SehT","FEbMpouv9cRyJBZv3","GtL5d4iFpEuoJacN7","H6wbK4u5jYRFL8LDs","Jeci2sNzJiMSDeJvc","QqoDaykDZWJd9YuAu","RLbGKAvkbQAw2q2pz","TCejZCDssndxpTcJg","TEAWLnKpXtQE8hs6C","dR2ye6bifAsonnNMz","eJ9fizm2KNxBgiNfF","gxe8DkJ5qKbznZgZq","hGdeHv63Gb3m6CybW","hShritfXo7Lzr2RkJ","jDvmx9aE5aohaf7P7","rQrciQZhPyL9ovwM8","ryLRyF5HAWnpncbbr","sFGhcvCCManvCwLHz","zTR82AHQxLXLWt4wi"],"dataSources":["TCkfRWJAZvbLAZi29"]}