@article{cook_anaesthesia_2018,
	title = {Anaesthesia, surgery, and life-threatening allergic reactions: protocol and methods of the 6th {National} {Audit} {Project} ({NAP6}) of the {Royal} {College} of {Anaesthetists}.},
	volume = {121},
	copyright = {Copyright (c) 2018 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.},
	issn = {1471-6771 0007-0912},
	doi = {10.1016/j.bja.2018.04.001},
	abstract = {BACKGROUND: Anaphylaxis during anaesthesia is a serious complication for patients and anaesthetists. METHODS: The Sixth National Audit Project (NAP6) of the Royal  College of Anaesthetists examined the incidence, predisposing factors, management, and impact of life-threatening perioperative anaphylaxis in the UK. NAP6 included: a national survey of anaesthetists' experiences and perceptions; a national survey of allergy clinics; a registry collecting detailed reports of all Grade 3-5 perioperative anaphylaxis cases for 1 yr; and a national survey of anaesthetic workload and perioperative allergen exposure. NHS and independent sector (IS) hospitals were approached to participate. Cases were reviewed by a multi-disciplinary expert panel (anaesthetists, intensivists, allergists, immunologists, patient representatives, and stakeholders) using a structured process designed to minimise bias. Clinical management and investigation were compared with published guidelines. This paper describes detailed study methods and reports on project engagement by NHS and IS hospitals. The methodology includes a new classification of perioperative anaphylaxis and a new structured method for classifying suspected anaphylactic events including the degree of certainty with which a causal trigger agent can be attributed. RESULTS: NHS engagement was complete (100\% of hospitals). Independent sector engagement was limited (13\% of approached hospitals). We received {\textgreater}500 reports of Grade 3-5 perioperative anaphylaxis, with 266 suitable for analysis. We identified 199 definite or probable culprit agents in 192 cases. CONCLUSIONS: The methods of NAP6 were robust in identifying causative agents of anaphylaxis, and support the  accompanying analytical papers.},
	language = {eng},
	number = {1},
	journal = {British journal of anaesthesia},
	author = {Cook, T. M. and Harper, N. J. N. and Farmer, L. and Garcez, T. and Floss, K. and Marinho, S. and Torevell, H. and Warner, A. and McGuire, N. and Ferguson, K. and Hitchman, J. and Egner, W. and Kemp, H. and Thomas, M. and Lucas, D. N. and Nasser, S. and Karanam, S. and Kong, K.-L. and Farooque, S. and Bellamy, M. and McGlennan, A. and Moonesinghe, S. R.},
	month = jul,
	year = {2018},
	pmid = {29935564},
	keywords = {Anaphylaxis/*epidemiology/therapy, Anesthesia/*adverse effects, Anesthetics/*adverse effects, Drug Hypersensitivity/*epidemiology/therapy, Humans, Incidence, Medical Audit/*methods, National Audit Project, Perioperative Period, Registries, Research Design, Surveys and Questionnaires, United Kingdom/epidemiology, allergy, anaesthesia, anaphylaxis},
	pages = {124--133},
}

{"_id":"QMmBrqzWwDGdGR25s","bibbaseid":"cook-harper-farmer-garcez-floss-marinho-torevell-warner-etal-anaesthesiasurgeryandlifethreateningallergicreactionsprotocolandmethodsofthe6thnationalauditprojectnap6oftheroyalcollegeofanaesthetists-2018","downloads":0,"creationDate":"2019-01-22T11:20:08.596Z","title":"Anaesthesia, surgery, and life-threatening allergic reactions: protocol and methods of the 6th National Audit Project (NAP6) of the Royal College of Anaesthetists.","author_short":["Cook, T. M.","Harper, N. J. N.","Farmer, L.","Garcez, T.","Floss, K.","Marinho, S.","Torevell, H.","Warner, A.","McGuire, N.","Ferguson, K.","Hitchman, J.","Egner, W.","Kemp, H.","Thomas, M.","Lucas, D. N.","Nasser, S.","Karanam, S.","Kong, K.","Farooque, S.","Bellamy, M.","McGlennan, A.","Moonesinghe, S. R."],"year":2018,"bibtype":"article","biburl":"https://api.zotero.org/groups/2278468/items?key=VdI1Arfo5ouMqRbfhtn5L0oK&format=bibtex&limit=100","bibdata":{"bibtype":"article","type":"article","title":"Anaesthesia, surgery, and life-threatening allergic reactions: protocol and methods of the 6th National Audit Project (NAP6) of the Royal College of Anaesthetists.","volume":"121","copyright":"Copyright (c) 2018 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.","issn":"1471-6771 0007-0912","doi":"10.1016/j.bja.2018.04.001","abstract":"BACKGROUND: Anaphylaxis during anaesthesia is a serious complication for patients and anaesthetists. METHODS: The Sixth National Audit Project (NAP6) of the Royal College of Anaesthetists examined the incidence, predisposing factors, management, and impact of life-threatening perioperative anaphylaxis in the UK. NAP6 included: a national survey of anaesthetists' experiences and perceptions; a national survey of allergy clinics; a registry collecting detailed reports of all Grade 3-5 perioperative anaphylaxis cases for 1 yr; and a national survey of anaesthetic workload and perioperative allergen exposure. NHS and independent sector (IS) hospitals were approached to participate. Cases were reviewed by a multi-disciplinary expert panel (anaesthetists, intensivists, allergists, immunologists, patient representatives, and stakeholders) using a structured process designed to minimise bias. Clinical management and investigation were compared with published guidelines. This paper describes detailed study methods and reports on project engagement by NHS and IS hospitals. The methodology includes a new classification of perioperative anaphylaxis and a new structured method for classifying suspected anaphylactic events including the degree of certainty with which a causal trigger agent can be attributed. RESULTS: NHS engagement was complete (100% of hospitals). Independent sector engagement was limited (13% of approached hospitals). We received \\textgreater500 reports of Grade 3-5 perioperative anaphylaxis, with 266 suitable for analysis. We identified 199 definite or probable culprit agents in 192 cases. CONCLUSIONS: The methods of NAP6 were robust in identifying causative agents of anaphylaxis, and support the accompanying analytical papers.","language":"eng","number":"1","journal":"British journal of anaesthesia","author":[{"propositions":[],"lastnames":["Cook"],"firstnames":["T.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Harper"],"firstnames":["N.","J.","N."],"suffixes":[]},{"propositions":[],"lastnames":["Farmer"],"firstnames":["L."],"suffixes":[]},{"propositions":[],"lastnames":["Garcez"],"firstnames":["T."],"suffixes":[]},{"propositions":[],"lastnames":["Floss"],"firstnames":["K."],"suffixes":[]},{"propositions":[],"lastnames":["Marinho"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Torevell"],"firstnames":["H."],"suffixes":[]},{"propositions":[],"lastnames":["Warner"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["McGuire"],"firstnames":["N."],"suffixes":[]},{"propositions":[],"lastnames":["Ferguson"],"firstnames":["K."],"suffixes":[]},{"propositions":[],"lastnames":["Hitchman"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Egner"],"firstnames":["W."],"suffixes":[]},{"propositions":[],"lastnames":["Kemp"],"firstnames":["H."],"suffixes":[]},{"propositions":[],"lastnames":["Thomas"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Lucas"],"firstnames":["D.","N."],"suffixes":[]},{"propositions":[],"lastnames":["Nasser"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Karanam"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Kong"],"firstnames":["K.-L."],"suffixes":[]},{"propositions":[],"lastnames":["Farooque"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Bellamy"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["McGlennan"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Moonesinghe"],"firstnames":["S.","R."],"suffixes":[]}],"month":"July","year":"2018","pmid":"29935564","keywords":"Anaphylaxis/*epidemiology/therapy, Anesthesia/*adverse effects, Anesthetics/*adverse effects, Drug Hypersensitivity/*epidemiology/therapy, Humans, Incidence, Medical Audit/*methods, National Audit Project, Perioperative Period, Registries, Research Design, Surveys and Questionnaires, United Kingdom/epidemiology, allergy, anaesthesia, anaphylaxis","pages":"124–133","bibtex":"@article{cook_anaesthesia_2018,\n\ttitle = {Anaesthesia, surgery, and life-threatening allergic reactions: protocol and methods of the 6th {National} {Audit} {Project} ({NAP6}) of the {Royal} {College} of {Anaesthetists}.},\n\tvolume = {121},\n\tcopyright = {Copyright (c) 2018 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.},\n\tissn = {1471-6771 0007-0912},\n\tdoi = {10.1016/j.bja.2018.04.001},\n\tabstract = {BACKGROUND: Anaphylaxis during anaesthesia is a serious complication for patients and anaesthetists. METHODS: The Sixth National Audit Project (NAP6) of the Royal College of Anaesthetists examined the incidence, predisposing factors, management, and impact of life-threatening perioperative anaphylaxis in the UK. NAP6 included: a national survey of anaesthetists' experiences and perceptions; a national survey of allergy clinics; a registry collecting detailed reports of all Grade 3-5 perioperative anaphylaxis cases for 1 yr; and a national survey of anaesthetic workload and perioperative allergen exposure. NHS and independent sector (IS) hospitals were approached to participate. Cases were reviewed by a multi-disciplinary expert panel (anaesthetists, intensivists, allergists, immunologists, patient representatives, and stakeholders) using a structured process designed to minimise bias. Clinical management and investigation were compared with published guidelines. This paper describes detailed study methods and reports on project engagement by NHS and IS hospitals. The methodology includes a new classification of perioperative anaphylaxis and a new structured method for classifying suspected anaphylactic events including the degree of certainty with which a causal trigger agent can be attributed. RESULTS: NHS engagement was complete (100\\% of hospitals). Independent sector engagement was limited (13\\% of approached hospitals). We received {\\textgreater}500 reports of Grade 3-5 perioperative anaphylaxis, with 266 suitable for analysis. We identified 199 definite or probable culprit agents in 192 cases. CONCLUSIONS: The methods of NAP6 were robust in identifying causative agents of anaphylaxis, and support the accompanying analytical papers.},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {British journal of anaesthesia},\n\tauthor = {Cook, T. M. and Harper, N. J. N. and Farmer, L. and Garcez, T. and Floss, K. and Marinho, S. and Torevell, H. and Warner, A. and McGuire, N. and Ferguson, K. and Hitchman, J. and Egner, W. and Kemp, H. and Thomas, M. and Lucas, D. N. and Nasser, S. and Karanam, S. and Kong, K.-L. and Farooque, S. and Bellamy, M. and McGlennan, A. and Moonesinghe, S. 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