Characterization and biological studies of a new platinum(II) complex with the amino acid L-alliin. Corbi, P. P., Massabni, A. C., Sabeh, L. P. B., & Costa-Neto, C. M. Journal of Coordination Chemistry, 61(15):2470–2477, 2008. doi abstract bibtex Synthesis and characterization of a new Pt(II) complex with the amino acid L-alliin (S-allyl-L-cysteine sulfoxide, C6H11NO3S) are described. Elemental and mass spectrometric analyses of the solid complex are consistent with [PtCl2(alliin)], or [PtCl2(C6H11NO3S)]. 13C nuclear magnetic resonance (NMR), [1H-15N] two dimensional (2D) NMR and infrared spectroscopy indicate coordination of the ligand to Pt(II) through the N and S atoms. The complex is very soluble in dimethyl sulfoxide. Biological analysis for evaluation of a potential cytotoxic effect of the complex was performed using HeLa cells derived from human cervical adenocarcinoma. The complex presented moderate cytotoxic activity, inducing about 40% cell death at a concentration of 400 μmol·L-1. © 2008 Taylor & Francis.
@article{corbi_characterization_2008,
title = {Characterization and biological studies of a new platinum({II}) complex with the amino acid {L}-alliin},
volume = {61},
issn = {00958972},
doi = {10.1080/00958970801930005},
abstract = {Synthesis and characterization of a new Pt(II) complex with the amino acid L-alliin (S-allyl-L-cysteine sulfoxide, C6H11NO3S) are described. Elemental and mass spectrometric analyses of the solid complex are consistent with [PtCl2(alliin)], or [PtCl2(C6H11NO3S)]. 13C nuclear magnetic resonance (NMR), [1H-15N] two dimensional (2D) NMR and infrared spectroscopy indicate coordination of the ligand to Pt(II) through the N and S atoms. The complex is very soluble in dimethyl sulfoxide. Biological analysis for evaluation of a potential cytotoxic effect of the complex was performed using HeLa cells derived from human cervical adenocarcinoma. The complex presented moderate cytotoxic activity, inducing about 40\% cell death at a concentration of 400 μmol·L-1. © 2008 Taylor \& Francis.},
number = {15},
journal = {Journal of Coordination Chemistry},
author = {Corbi, P. P. and Massabni, A. C. and Sabeh, L. P. B. and Costa-Neto, C. M.},
year = {2008},
keywords = {15N resonance, Cytotoxicity, L-alliin, Platinum(II), S-allyl-L-cysteine sulfoxide},
pages = {2470--2477},
}
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