Accelerated high-resolution free-breathing 3D whole-heart T2-prepared black-blood and bright-blood cardiovascular magnetic resonance. Correia, T., Ginami, G., Rashid, I., Nordio, G., Hajhosseiny, R., Ismail, T. F., Neji, R., Botnar, R. M., & Prieto, C. Journal of Cardiovascular Magnetic Resonance: Official Journal of the Society for Cardiovascular Magnetic Resonance, 22(1):88, December, 2020. doi abstract bibtex BACKGROUND: The free-breathing 3D whole-heart T2-prepared Bright-blood and black-blOOd phase SensiTive inversion recovery (BOOST) cardiovascular magnetic resonance (CMR) sequence was recently proposed for simultaneous bright-blood coronary CMR angiography and black-blood late gadolinium enhancement (LGE) imaging. This sequence enables simultaneous visualization of cardiac anatomy, coronary arteries and fibrosis. However, high-resolution (\textless 1.4 × 1.4 × 1.4 mm3) fully-sampled BOOST requires long acquisition times of ~ 20 min. METHODS: In this work, we propose to extend a highly efficient respiratory-resolved motion-corrected reconstruction framework (XD-ORCCA) to T2-prepared BOOST to enable high-resolution 3D whole-heart coronary CMR angiography and black-blood LGE in a clinically feasible scan time. Twelve healthy subjects were imaged without contrast injection (pre-contrast BOOST) and 10 patients with suspected cardiovascular disease were imaged after contrast injection (post-contrast BOOST). A quantitative analysis software was used to compare accelerated pre-contrast BOOST against the fully-sampled counterpart (vessel sharpness and length of the left and right coronary arteries). Moreover, three cardiologists performed diagnostic image quality scoring for clinical 2D LGE and both bright- and black-blood 3D BOOST imaging using a 4-point scale (1-4, non-diagnostic-fully diagnostic). A two one-sided test of equivalence (TOST) was performed to compare the pre-contrast BOOST images. Nonparametric TOST was performed to compare post-contrast BOOST image quality scores. RESULTS: The proposed method produces images from 3.8 × accelerated non-contrast-enhanced BOOST acquisitions with comparable vessel length and sharpness to those obtained from fully- sampled scans in healthy subjects. Moreover, in terms of visual grading, the 3D BOOST LGE datasets (median 4) and the clinical 2D counterpart (median 3.5) were found to be statistically equivalent (p \textless 0.05). In addition, bright-blood BOOST images allowed for visualization of the proximal and middle left anterior descending and right coronary sections with high diagnostic quality (mean score \textgreater 3.5). CONCLUSIONS: The proposed framework provides high-resolution 3D whole-heart BOOST images from a single free-breathing acquisition in ~ 7 min.
@article{correia_accelerated_2020,
title = {Accelerated high-resolution free-breathing {3D} whole-heart {T2}-prepared black-blood and bright-blood cardiovascular magnetic resonance},
volume = {22},
issn = {1532-429X},
doi = {10.1186/s12968-020-00691-3},
abstract = {BACKGROUND: The free-breathing 3D whole-heart T2-prepared Bright-blood and black-blOOd phase SensiTive inversion recovery (BOOST) cardiovascular magnetic resonance (CMR) sequence was recently proposed for simultaneous bright-blood coronary CMR angiography and black-blood late gadolinium enhancement (LGE) imaging. This sequence enables simultaneous visualization of cardiac anatomy, coronary arteries and fibrosis. However, high-resolution ({\textless} 1.4 × 1.4 × 1.4 mm3) fully-sampled BOOST requires long acquisition times of {\textasciitilde} 20 min.
METHODS: In this work, we propose to extend a highly efficient respiratory-resolved motion-corrected reconstruction framework (XD-ORCCA) to T2-prepared BOOST to enable high-resolution 3D whole-heart coronary CMR angiography and black-blood LGE in a clinically feasible scan time. Twelve healthy subjects were imaged without contrast injection (pre-contrast BOOST) and 10 patients with suspected cardiovascular disease were imaged after contrast injection (post-contrast BOOST). A quantitative analysis software was used to compare accelerated pre-contrast BOOST against the fully-sampled counterpart (vessel sharpness and length of the left and right coronary arteries). Moreover, three cardiologists performed diagnostic image quality scoring for clinical 2D LGE and both bright- and black-blood 3D BOOST imaging using a 4-point scale (1-4, non-diagnostic-fully diagnostic). A two one-sided test of equivalence (TOST) was performed to compare the pre-contrast BOOST images. Nonparametric TOST was performed to compare post-contrast BOOST image quality scores.
RESULTS: The proposed method produces images from 3.8 × accelerated non-contrast-enhanced BOOST acquisitions with comparable vessel length and sharpness to those obtained from fully- sampled scans in healthy subjects. Moreover, in terms of visual grading, the 3D BOOST LGE datasets (median 4) and the clinical 2D counterpart (median 3.5) were found to be statistically equivalent (p {\textless} 0.05). In addition, bright-blood BOOST images allowed for visualization of the proximal and middle left anterior descending and right coronary sections with high diagnostic quality (mean score {\textgreater} 3.5).
CONCLUSIONS: The proposed framework provides high-resolution 3D whole-heart BOOST images from a single free-breathing acquisition in {\textasciitilde} 7 min.},
language = {eng},
number = {1},
journal = {Journal of Cardiovascular Magnetic Resonance: Official Journal of the Society for Cardiovascular Magnetic Resonance},
author = {Correia, Teresa and Ginami, Giulia and Rashid, Imran and Nordio, Giovanna and Hajhosseiny, Reza and Ismail, Tevfik F. and Neji, Radhouene and Botnar, René M. and Prieto, Claudia},
month = dec,
year = {2020},
pmid = {33317570},
pmcid = {PMC7737390},
keywords = {Adult, Aged, Aged, 80 and over, Black-blood, Case-Control Studies, Compressed sensing, Contrast Media, Coronary Vessels, Coronary magnetic resonance angiography (CMRA), Female, Fibrosis, Heart Diseases, Humans, Image navigator, Imaging, Three-Dimensional, Late gadolinium enhancement (LGE), Magnetic Resonance Imaging, Male, Middle Aged, Myocardium, Predictive Value of Tests, Reproducibility of Results, Respiratory motion compensation, Workflow, Young Adult},
pages = {88},
}
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This sequence enables simultaneous visualization of cardiac anatomy, coronary arteries and fibrosis. However, high-resolution (\\textless 1.4 × 1.4 × 1.4 mm3) fully-sampled BOOST requires long acquisition times of ~ 20 min. METHODS: In this work, we propose to extend a highly efficient respiratory-resolved motion-corrected reconstruction framework (XD-ORCCA) to T2-prepared BOOST to enable high-resolution 3D whole-heart coronary CMR angiography and black-blood LGE in a clinically feasible scan time. Twelve healthy subjects were imaged without contrast injection (pre-contrast BOOST) and 10 patients with suspected cardiovascular disease were imaged after contrast injection (post-contrast BOOST). A quantitative analysis software was used to compare accelerated pre-contrast BOOST against the fully-sampled counterpart (vessel sharpness and length of the left and right coronary arteries). Moreover, three cardiologists performed diagnostic image quality scoring for clinical 2D LGE and both bright- and black-blood 3D BOOST imaging using a 4-point scale (1-4, non-diagnostic-fully diagnostic). A two one-sided test of equivalence (TOST) was performed to compare the pre-contrast BOOST images. Nonparametric TOST was performed to compare post-contrast BOOST image quality scores. RESULTS: The proposed method produces images from 3.8 × accelerated non-contrast-enhanced BOOST acquisitions with comparable vessel length and sharpness to those obtained from fully- sampled scans in healthy subjects. Moreover, in terms of visual grading, the 3D BOOST LGE datasets (median 4) and the clinical 2D counterpart (median 3.5) were found to be statistically equivalent (p \\textless 0.05). In addition, bright-blood BOOST images allowed for visualization of the proximal and middle left anterior descending and right coronary sections with high diagnostic quality (mean score \\textgreater 3.5). CONCLUSIONS: The proposed framework provides high-resolution 3D whole-heart BOOST images from a single free-breathing acquisition in ~ 7 min.","language":"eng","number":"1","journal":"Journal of Cardiovascular Magnetic Resonance: Official Journal of the Society for Cardiovascular Magnetic Resonance","author":[{"propositions":[],"lastnames":["Correia"],"firstnames":["Teresa"],"suffixes":[]},{"propositions":[],"lastnames":["Ginami"],"firstnames":["Giulia"],"suffixes":[]},{"propositions":[],"lastnames":["Rashid"],"firstnames":["Imran"],"suffixes":[]},{"propositions":[],"lastnames":["Nordio"],"firstnames":["Giovanna"],"suffixes":[]},{"propositions":[],"lastnames":["Hajhosseiny"],"firstnames":["Reza"],"suffixes":[]},{"propositions":[],"lastnames":["Ismail"],"firstnames":["Tevfik","F."],"suffixes":[]},{"propositions":[],"lastnames":["Neji"],"firstnames":["Radhouene"],"suffixes":[]},{"propositions":[],"lastnames":["Botnar"],"firstnames":["René","M."],"suffixes":[]},{"propositions":[],"lastnames":["Prieto"],"firstnames":["Claudia"],"suffixes":[]}],"month":"December","year":"2020","pmid":"33317570","pmcid":"PMC7737390","keywords":"Adult, Aged, Aged, 80 and over, Black-blood, Case-Control Studies, Compressed sensing, Contrast Media, Coronary Vessels, Coronary magnetic resonance angiography (CMRA), Female, Fibrosis, Heart Diseases, Humans, Image navigator, Imaging, Three-Dimensional, Late gadolinium enhancement (LGE), Magnetic Resonance Imaging, Male, Middle Aged, Myocardium, Predictive Value of Tests, Reproducibility of Results, Respiratory motion compensation, Workflow, Young Adult","pages":"88","bibtex":"@article{correia_accelerated_2020,\n\ttitle = {Accelerated high-resolution free-breathing {3D} whole-heart {T2}-prepared black-blood and bright-blood cardiovascular magnetic resonance},\n\tvolume = {22},\n\tissn = {1532-429X},\n\tdoi = {10.1186/s12968-020-00691-3},\n\tabstract = {BACKGROUND: The free-breathing 3D whole-heart T2-prepared Bright-blood and black-blOOd phase SensiTive inversion recovery (BOOST) cardiovascular magnetic resonance (CMR) sequence was recently proposed for simultaneous bright-blood coronary CMR angiography and black-blood late gadolinium enhancement (LGE) imaging. This sequence enables simultaneous visualization of cardiac anatomy, coronary arteries and fibrosis. However, high-resolution ({\\textless} 1.4 × 1.4 × 1.4 mm3) fully-sampled BOOST requires long acquisition times of {\\textasciitilde} 20 min.\nMETHODS: In this work, we propose to extend a highly efficient respiratory-resolved motion-corrected reconstruction framework (XD-ORCCA) to T2-prepared BOOST to enable high-resolution 3D whole-heart coronary CMR angiography and black-blood LGE in a clinically feasible scan time. Twelve healthy subjects were imaged without contrast injection (pre-contrast BOOST) and 10 patients with suspected cardiovascular disease were imaged after contrast injection (post-contrast BOOST). A quantitative analysis software was used to compare accelerated pre-contrast BOOST against the fully-sampled counterpart (vessel sharpness and length of the left and right coronary arteries). Moreover, three cardiologists performed diagnostic image quality scoring for clinical 2D LGE and both bright- and black-blood 3D BOOST imaging using a 4-point scale (1-4, non-diagnostic-fully diagnostic). A two one-sided test of equivalence (TOST) was performed to compare the pre-contrast BOOST images. Nonparametric TOST was performed to compare post-contrast BOOST image quality scores.\nRESULTS: The proposed method produces images from 3.8 × accelerated non-contrast-enhanced BOOST acquisitions with comparable vessel length and sharpness to those obtained from fully- sampled scans in healthy subjects. Moreover, in terms of visual grading, the 3D BOOST LGE datasets (median 4) and the clinical 2D counterpart (median 3.5) were found to be statistically equivalent (p {\\textless} 0.05). In addition, bright-blood BOOST images allowed for visualization of the proximal and middle left anterior descending and right coronary sections with high diagnostic quality (mean score {\\textgreater} 3.5).\nCONCLUSIONS: The proposed framework provides high-resolution 3D whole-heart BOOST images from a single free-breathing acquisition in {\\textasciitilde} 7 min.},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {Journal of Cardiovascular Magnetic Resonance: Official Journal of the Society for Cardiovascular Magnetic Resonance},\n\tauthor = {Correia, Teresa and Ginami, Giulia and Rashid, Imran and Nordio, Giovanna and Hajhosseiny, Reza and Ismail, Tevfik F. and Neji, Radhouene and Botnar, René M. and Prieto, Claudia},\n\tmonth = dec,\n\tyear = {2020},\n\tpmid = {33317570},\n\tpmcid = {PMC7737390},\n\tkeywords = {Adult, Aged, Aged, 80 and over, Black-blood, Case-Control Studies, Compressed sensing, Contrast Media, Coronary Vessels, Coronary magnetic resonance angiography (CMRA), Female, Fibrosis, Heart Diseases, Humans, Image navigator, Imaging, Three-Dimensional, Late gadolinium enhancement (LGE), Magnetic Resonance Imaging, Male, Middle Aged, Myocardium, Predictive Value of Tests, Reproducibility of Results, Respiratory motion compensation, Workflow, Young Adult},\n\tpages = {88},\n}\n\n","author_short":["Correia, T.","Ginami, G.","Rashid, I.","Nordio, G.","Hajhosseiny, R.","Ismail, T. 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