Strength of attention-sampling parietal EEG theta rhythm is linked to impaired inhibition in adult ADHD. Cowley, B. U., Juurmaa, K., & Palomäki, J. 2020. Publisher: Cold Spring Harbor Laboratory Pressdoi abstract bibtex Attention-deficit hyperactivity disorder (ADHD) in adults is understudied, especially regarding neural mechanisms such as oscillatory control of attention sampling. We report an EEG study of such cortical oscillations, in ADHD-diagnosed adults taking a continuous performance test that measures the ability to sustain attention and inhibit impulsivity for a prolonged period of time.We recorded 53 adults (28f, 25m, aged 18-60), and 18 matched healthy controls, using 128-channel EEG. We analysed features with established links to neural correlates of attention: event-related (de)synchronisation (ERS/D), alpha and theta frequency band activation, phase-locking value (PLV), and timing-sensitivity indices; in frontal and parietal scalp regions.Test performance distinguished healthy controls from ADHD adults. The ADHD group manifested significantly less parietal pre-stimulus 8Hz theta ERS during correct inhibition trials, less frontal amp; parietal post-stimulus 4Hz theta ERS during inhibition amp; response trials, and increased frontal amp; parietal pre-stimulus alpha ERS during inhibition amp; response. They showed significantly reduced fronto-parietal connectivity that lagged across trials and was strongly lateralised. In addition, they had reduced sensitivity to targets in stimulus-locking measures.Building on the hypothesis of parietal attention sampling, our results suggest that ADHD adults have impaired attention sampling in relational categorisation tasks.Competing Interest StatementThe authors have declared no competing interest.Funding StatementPartly funded by Finnish science agency TEKES, project $$440078. No payment, or services from a third party, were received for any aspect of the submitted work.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:The Ethical Committee of the Hospital District of Helsinki and Uusimaa, 28/03/2012, 621/1999, 24All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).YesI have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesParticipants did not explicitly consent to the release of the data recorded in the study, and thus datasets are not made publicly available.
@misc{cowley_strength_2020,
title = {Strength of attention-sampling parietal {EEG} theta rhythm is linked to impaired inhibition in adult {ADHD}},
doi = {10.1101/2020.06.03.20120964},
abstract = {Attention-deficit hyperactivity disorder (ADHD) in adults is understudied, especially regarding neural mechanisms such as oscillatory control of attention sampling. We report an EEG study of such cortical oscillations, in ADHD-diagnosed adults taking a continuous performance test that measures the ability to sustain attention and inhibit impulsivity for a prolonged period of time.We recorded 53 adults (28f, 25m, aged 18-60), and 18 matched healthy controls, using 128-channel EEG. We analysed features with established links to neural correlates of attention: event-related (de)synchronisation (ERS/D), alpha and theta frequency band activation, phase-locking value (PLV), and timing-sensitivity indices; in frontal and parietal scalp regions.Test performance distinguished healthy controls from ADHD adults. The ADHD group manifested significantly less parietal pre-stimulus 8Hz theta ERS during correct inhibition trials, less frontal amp; parietal post-stimulus 4Hz theta ERS during inhibition amp; response trials, and increased frontal amp; parietal pre-stimulus alpha ERS during inhibition amp; response. They showed significantly reduced fronto-parietal connectivity that lagged across trials and was strongly lateralised. In addition, they had reduced sensitivity to targets in stimulus-locking measures.Building on the hypothesis of parietal attention sampling, our results suggest that ADHD adults have impaired attention sampling in relational categorisation tasks.Competing Interest StatementThe authors have declared no competing interest.Funding StatementPartly funded by Finnish science agency TEKES, project \$\$440078. No payment, or services from a third party, were received for any aspect of the submitted work.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:The Ethical Committee of the Hospital District of Helsinki and Uusimaa, 28/03/2012, 621/1999, 24All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).YesI have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesParticipants did not explicitly consent to the release of the data recorded in the study, and thus datasets are not made publicly available.},
language = {English},
author = {Cowley, Benjamin Ultan and Juurmaa, Kristiina and Palomäki, Jussi},
year = {2020},
note = {Publisher: Cold Spring Harbor Laboratory Press},
keywords = {3124 Neurology and psychiatry},
}
Downloads: 0
{"_id":"edoeNqjnFeigEi5Da","bibbaseid":"cowley-juurmaa-palomki-strengthofattentionsamplingparietaleegthetarhythmislinkedtoimpairedinhibitioninadultadhd-2020","author_short":["Cowley, B. U.","Juurmaa, K.","Palomäki, J."],"bibdata":{"bibtype":"misc","type":"misc","title":"Strength of attention-sampling parietal EEG theta rhythm is linked to impaired inhibition in adult ADHD","doi":"10.1101/2020.06.03.20120964","abstract":"Attention-deficit hyperactivity disorder (ADHD) in adults is understudied, especially regarding neural mechanisms such as oscillatory control of attention sampling. We report an EEG study of such cortical oscillations, in ADHD-diagnosed adults taking a continuous performance test that measures the ability to sustain attention and inhibit impulsivity for a prolonged period of time.We recorded 53 adults (28f, 25m, aged 18-60), and 18 matched healthy controls, using 128-channel EEG. We analysed features with established links to neural correlates of attention: event-related (de)synchronisation (ERS/D), alpha and theta frequency band activation, phase-locking value (PLV), and timing-sensitivity indices; in frontal and parietal scalp regions.Test performance distinguished healthy controls from ADHD adults. The ADHD group manifested significantly less parietal pre-stimulus 8Hz theta ERS during correct inhibition trials, less frontal amp; parietal post-stimulus 4Hz theta ERS during inhibition amp; response trials, and increased frontal amp; parietal pre-stimulus alpha ERS during inhibition amp; response. They showed significantly reduced fronto-parietal connectivity that lagged across trials and was strongly lateralised. In addition, they had reduced sensitivity to targets in stimulus-locking measures.Building on the hypothesis of parietal attention sampling, our results suggest that ADHD adults have impaired attention sampling in relational categorisation tasks.Competing Interest StatementThe authors have declared no competing interest.Funding StatementPartly funded by Finnish science agency TEKES, project $$440078. No payment, or services from a third party, were received for any aspect of the submitted work.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:The Ethical Committee of the Hospital District of Helsinki and Uusimaa, 28/03/2012, 621/1999, 24All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).YesI have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesParticipants did not explicitly consent to the release of the data recorded in the study, and thus datasets are not made publicly available.","language":"English","author":[{"propositions":[],"lastnames":["Cowley"],"firstnames":["Benjamin","Ultan"],"suffixes":[]},{"propositions":[],"lastnames":["Juurmaa"],"firstnames":["Kristiina"],"suffixes":[]},{"propositions":[],"lastnames":["Palomäki"],"firstnames":["Jussi"],"suffixes":[]}],"year":"2020","note":"Publisher: Cold Spring Harbor Laboratory Press","keywords":"3124 Neurology and psychiatry","bibtex":"@misc{cowley_strength_2020,\n\ttitle = {Strength of attention-sampling parietal {EEG} theta rhythm is linked to impaired inhibition in adult {ADHD}},\n\tdoi = {10.1101/2020.06.03.20120964},\n\tabstract = {Attention-deficit hyperactivity disorder (ADHD) in adults is understudied, especially regarding neural mechanisms such as oscillatory control of attention sampling. We report an EEG study of such cortical oscillations, in ADHD-diagnosed adults taking a continuous performance test that measures the ability to sustain attention and inhibit impulsivity for a prolonged period of time.We recorded 53 adults (28f, 25m, aged 18-60), and 18 matched healthy controls, using 128-channel EEG. We analysed features with established links to neural correlates of attention: event-related (de)synchronisation (ERS/D), alpha and theta frequency band activation, phase-locking value (PLV), and timing-sensitivity indices; in frontal and parietal scalp regions.Test performance distinguished healthy controls from ADHD adults. The ADHD group manifested significantly less parietal pre-stimulus 8Hz theta ERS during correct inhibition trials, less frontal amp; parietal post-stimulus 4Hz theta ERS during inhibition amp; response trials, and increased frontal amp; parietal pre-stimulus alpha ERS during inhibition amp; response. They showed significantly reduced fronto-parietal connectivity that lagged across trials and was strongly lateralised. In addition, they had reduced sensitivity to targets in stimulus-locking measures.Building on the hypothesis of parietal attention sampling, our results suggest that ADHD adults have impaired attention sampling in relational categorisation tasks.Competing Interest StatementThe authors have declared no competing interest.Funding StatementPartly funded by Finnish science agency TEKES, project \\$\\$440078. No payment, or services from a third party, were received for any aspect of the submitted work.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:The Ethical Committee of the Hospital District of Helsinki and Uusimaa, 28/03/2012, 621/1999, 24All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).YesI have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesParticipants did not explicitly consent to the release of the data recorded in the study, and thus datasets are not made publicly available.},\n\tlanguage = {English},\n\tauthor = {Cowley, Benjamin Ultan and Juurmaa, Kristiina and Palomäki, Jussi},\n\tyear = {2020},\n\tnote = {Publisher: Cold Spring Harbor Laboratory Press},\n\tkeywords = {3124 Neurology and psychiatry},\n}\n\n","author_short":["Cowley, B. U.","Juurmaa, K.","Palomäki, J."],"key":"cowley_strength_2020","id":"cowley_strength_2020","bibbaseid":"cowley-juurmaa-palomki-strengthofattentionsamplingparietaleegthetarhythmislinkedtoimpairedinhibitioninadultadhd-2020","role":"author","urls":{},"keyword":["3124 Neurology and psychiatry"],"metadata":{"authorlinks":{}}},"bibtype":"misc","biburl":"https://api.zotero.org/users/19634/collections/TV78LMMA/items?key=F9XtACoGIqxy1Fi3Cdhh8Bxq&format=bibtex&limit=100","dataSources":["rt4MrmmGcSWT2Y9t4","64t5GHojmyNGvCTor","AQiMfQvX7ga5gRq8M"],"keywords":["3124 neurology and psychiatry"],"search_terms":["strength","attention","sampling","parietal","eeg","theta","rhythm","linked","impaired","inhibition","adult","adhd","cowley","juurmaa","palomäki"],"title":"Strength of attention-sampling parietal EEG theta rhythm is linked to impaired inhibition in adult ADHD","year":2020}