Conserved Roles of the H3K27ME3 Epigenome on Plant Development. Crevillén, P., Poza-Viejo, L., Payá-Milans, M., Del Olmo, I., & Wilkinson​, M., D. IMPACT OF CHROMATIN DOMAINS ON PLANT PHENOTYPES, The Society for Experimental Biology, 2019.
Conserved Roles of the H3K27ME3 Epigenome on Plant Development [pdf]Website  abstract   bibtex   
The study of the epigenome and its relation with the underlying genome sequence has become a central question in Biology nowadays. Genome-wide maps of histone modifications have been obtained for several plant species. However, most studies focus on model systems and do not enforce FAIR data management principles. We have developed a Reproducible Epigenomics Analysis (REA) pipeline combining a Galaxy environment for data analysis and Jupyter notebooks for results visualization composed into Docker. We successfully applied this REA pipeline to study of the H3K27m3 epigenome on leaves and flowers of plant model (Arabidopsis thaliana) and crop (Brassica rapa) species. The comparative analysis between leaves and inflorescences genomic datasets suggested that the expression of various floral regulatory genes during development is controlled by H3K27 methylation. H3K27me3 is a repressive epigenetic mark set by Polycomb protein complexes and counteracted by the histone demethylase activity of specific Jumonji domain proteins. We are also studying the role of these epigenetic factors in A. thaliana and B. rapa. Mutant analyses have shown that these epigenetic factors regulate a wide range of developmental responses including flowering time. The similarities and differences between model and crop systems on the role of H3K27me

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