Sponsorship bias in the comparative efficacy of psychotherapy and pharmacotherapy for adult depression: meta-analysis. Cristea, I. A., Gentili, C., Pietrini, P., & Cuijpers, P. The British Journal of Psychiatry: The Journal of Mental Science, 210(1):16–23, 2017. ![Sponsorship bias in the comparative efficacy of psychotherapy and pharmacotherapy for adult depression: meta-analysis [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex BACKGROUND: Sponsorship bias has never been investigated for non-pharmacological treatments like psychotherapy. AIMS: We examined industry funding and author financial conflict of interest (COI) in randomised controlled trials directly comparing psychotherapy and pharmacotherapy in depression. METHOD: We conducted a meta-analysis with subgroup comparisons for industry v. non-industry-funded trials, and respectively for trial reports with author financial COI v. those without. RESULTS: In total, 45 studies were included. In most analyses, pharmacotherapy consistently showed significant effectiveness over psychotherapy, g = -0.11 (95% CI -0.21 to -0.02) in industry-funded trials. Differences between industry and non-industry-funded trials were significant, a result only partly confirmed in sensitivity analyses. We identified five instances where authors of the original article had not reported financial COI. CONCLUSIONS: Industry-funded trials for depression appear to subtly favour pharmacotherapy over psychotherapy. Disclosure of all financial ties with the pharmaceutical industry should be encouraged.
@article{cristea_sponsorship_2017,
title = {Sponsorship bias in the comparative efficacy of psychotherapy and pharmacotherapy for adult depression: meta-analysis},
volume = {210},
issn = {1472-1465},
shorttitle = {Sponsorship bias in the comparative efficacy of psychotherapy and pharmacotherapy for adult depression},
url = {https://www.ncbi.nlm.nih.gov/pubmed/27810891},
doi = {10.1192/bjp.bp.115.179275},
abstract = {BACKGROUND: Sponsorship bias has never been investigated for non-pharmacological treatments like psychotherapy.
AIMS: We examined industry funding and author financial conflict of interest (COI) in randomised controlled trials directly comparing psychotherapy and pharmacotherapy in depression.
METHOD: We conducted a meta-analysis with subgroup comparisons for industry v. non-industry-funded trials, and respectively for trial reports with author financial COI v. those without.
RESULTS: In total, 45 studies were included. In most analyses, pharmacotherapy consistently showed significant effectiveness over psychotherapy, g = -0.11 (95\% CI -0.21 to -0.02) in industry-funded trials. Differences between industry and non-industry-funded trials were significant, a result only partly confirmed in sensitivity analyses. We identified five instances where authors of the original article had not reported financial COI.
CONCLUSIONS: Industry-funded trials for depression appear to subtly favour pharmacotherapy over psychotherapy. Disclosure of all financial ties with the pharmaceutical industry should be encouraged.},
language = {eng},
number = {1},
journal = {The British Journal of Psychiatry: The Journal of Mental Science},
author = {Cristea, Ioana A. and Gentili, Claudio and Pietrini, Pietro and Cuijpers, Pim},
year = {2017},
pmid = {27810891},
keywords = {8 Ignorance and funding bias, Antidepressive Agents, Biais de financement, Conflict of Interest, Depressive Disorder, Drug Industry, Humans, Outcome Assessment (Health Care), PRINTED (Fonds papier), Psychotherapy, Randomized Controlled Trials as Topic},
pages = {16--23},
}
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METHOD: We conducted a meta-analysis with subgroup comparisons for industry v. non-industry-funded trials, and respectively for trial reports with author financial COI v. those without. RESULTS: In total, 45 studies were included. In most analyses, pharmacotherapy consistently showed significant effectiveness over psychotherapy, g = -0.11 (95% CI -0.21 to -0.02) in industry-funded trials. Differences between industry and non-industry-funded trials were significant, a result only partly confirmed in sensitivity analyses. We identified five instances where authors of the original article had not reported financial COI. CONCLUSIONS: Industry-funded trials for depression appear to subtly favour pharmacotherapy over psychotherapy. 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