@article{croce_immunotherapeutic_2012,
	title = {Immunotherapeutic applications of {IL}-15},
	volume = {4},
	issn = {1750-7448 (ELECTRONIC) 1750-743X (LINKING)},
	shorttitle = {Immunotherapeutic applications of {IL}-15},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/23046239},
	abstract = {IL-15 is a member of the IL-2 family of cytokines, which play a fundamental role in innate and adaptive immune responses. IL-15 has pleiotropic immune-enhancing activities, as it stimulates NK, T and NKT cell proliferation, survival and effector functions. In view of these properties, IL-15 is regarded as a good candidate for cancer immunotherapy. This possibility is reinforced by its low toxicity and efficacy in preclinical tumor models. The use of IL-15 to boost the immune response in HIV infection has also been proposed, although further studies are required to establish potential risks and benefits. Clinical trials of IL-15 have been initiated in cancer patients and in HIV vaccination and will elucidate the potential of IL-15-based immunotherapy. The purpose of this review is to provide an update on the potential applications of IL-15 in cancer immunotherapy and HIV infection.},
	number = {9},
	journal = {Immunotherapy},
	author = {Croce, M. and Orengo, A. M. and Azzarone, B. and Ferrini, S.},
	month = sep,
	year = {2012},
	keywords = {Animals, Clinical, HIV, Humans, Immunotherapy, Infections/*drug, Interleukin-15/physiology/*therapeutic, Neoplasms/*drug, Therapy, Topic, Trials, as, use/toxicity},
	pages = {957--69},
}

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