European Working Group on SARS-CoV-2: Current Understanding, Unknowns, and Recommendations on the Neurological Complications of COVID-19. Crook, H., Ramirez, A., Hosseini, A. A., Vavougyios, G., Lehmann, C., Bruchfeld, J., Schneider, A., d'Avossa , G., Lo Re, V., Salmoiraghi, A., Mukaetova-Ladinska, E., Katshu, M., Boneschi, F. M., Hakansson, K., Geerlings, M., Pracht, E., Ruiz, A., Jansen, J. F., Snyder, H., Kivipelto, M., & Edison, P. Brain Connect, 2023. Crook, Harry Ramirez, Alfredo Hosseini, Akram A Vavougyios, Georgios Lehmann, Clara Bruchfeld, Judith Schneider, Anja d'Avossa, Giovanni Lo Re, Vincenzina Salmoiraghi, Alberto Mukaetova-Ladinska, Elizabeta Katshu, Mohammad Boneschi, Filippo M Hakansson, Krister Geerlings, Mirjam Pracht, Elisabeth Ruiz, Agustin Jansen, Jacobus Fa Snyder, Heather Kivipelto, Miia Edison, Paul eng Brain Connect. 2023 Jan 31. doi: 10.1089/brain.2022.0058.
Paper doi abstract bibtex The emergence of COVID-19 was rapidly followed by infection and the deaths of millions of people across the globe. With much of the research and scientific advancement rightly focused on reducing the burden of severe and critical acute COVID-19 infection, the long-term effects endured by those who survived the acute infection has been previously overlooked. Now, an appreciation for the post-COVID-19 condition, including its neurological manifestations, is growing, although there remain many unknowns regarding the aetiology and risk factors of the condition, as well as how to effectively diagnose and treat it. Here, drawing upon the experiences and expertise of the clinicians and academics of the European working group on COVID-19, we have reviewed the current literature to provide a comprehensive overview of the neurological sequalae of the post-COVID-19 condition. In this review, we provide a summary of the neurological symptoms associated with the post-COVID-19 condition, before discussing the possible mechanisms which may underly and manifest these symptoms. Following this, we explore the risk factors for developing neurological symptoms as a result of COVID-19 and the post-COVID-19 condition, as well as how COVID-19 infection may itself be a risk factor for the development of neurological disease in the future. Lastly, we evaluate how the post-COVID condition could be accurately diagnosed and effectively treated, including examples of the current guidelines, clinical outcomes and tools that have been developed to aid in this process, as well as addressing the protection provided by COVID-19 vaccines against post-COVID-19 condition. Overall, this review provides a comprehensive overview of the neurological sequalae of the post-COVID-19 condition.
@article{RN317,
author = {Crook, H. and Ramirez, A. and Hosseini, A. A. and Vavougyios, G. and Lehmann, C. and Bruchfeld, J. and Schneider, A. and d'Avossa, G. and Lo Re, V. and Salmoiraghi, A. and Mukaetova-Ladinska, E. and Katshu, M. and Boneschi, F. M. and Hakansson, K. and Geerlings, M. and Pracht, E. and Ruiz, A. and Jansen, J. F. and Snyder, H. and Kivipelto, M. and Edison, P.},
title = {European Working Group on SARS-CoV-2: Current Understanding, Unknowns, and Recommendations on the Neurological Complications of COVID-19},
journal = {Brain Connect},
note = {Crook, Harry
Ramirez, Alfredo
Hosseini, Akram A
Vavougyios, Georgios
Lehmann, Clara
Bruchfeld, Judith
Schneider, Anja
d'Avossa, Giovanni
Lo Re, Vincenzina
Salmoiraghi, Alberto
Mukaetova-Ladinska, Elizabeta
Katshu, Mohammad
Boneschi, Filippo M
Hakansson, Krister
Geerlings, Mirjam
Pracht, Elisabeth
Ruiz, Agustin
Jansen, Jacobus Fa
Snyder, Heather
Kivipelto, Miia
Edison, Paul
eng
Brain Connect. 2023 Jan 31. doi: 10.1089/brain.2022.0058.},
abstract = {The emergence of COVID-19 was rapidly followed by infection and the deaths of millions of people across the globe. With much of the research and scientific advancement rightly focused on reducing the burden of severe and critical acute COVID-19 infection, the long-term effects endured by those who survived the acute infection has been previously overlooked. Now, an appreciation for the post-COVID-19 condition, including its neurological manifestations, is growing, although there remain many unknowns regarding the aetiology and risk factors of the condition, as well as how to effectively diagnose and treat it. Here, drawing upon the experiences and expertise of the clinicians and academics of the European working group on COVID-19, we have reviewed the current literature to provide a comprehensive overview of the neurological sequalae of the post-COVID-19 condition. In this review, we provide a summary of the neurological symptoms associated with the post-COVID-19 condition, before discussing the possible mechanisms which may underly and manifest these symptoms. Following this, we explore the risk factors for developing neurological symptoms as a result of COVID-19 and the post-COVID-19 condition, as well as how COVID-19 infection may itself be a risk factor for the development of neurological disease in the future. Lastly, we evaluate how the post-COVID condition could be accurately diagnosed and effectively treated, including examples of the current guidelines, clinical outcomes and tools that have been developed to aid in this process, as well as addressing the protection provided by COVID-19 vaccines against post-COVID-19 condition. Overall, this review provides a comprehensive overview of the neurological sequalae of the post-COVID-19 condition.},
keywords = {Cognition
Neurology},
ISSN = {2158-0022 (Electronic)
2158-0014 (Linking)},
DOI = {10.1089/brain.2022.0058},
url = {https://www.ncbi.nlm.nih.gov/pubmed/36719785},
year = {2023},
type = {Journal Article}
}
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