Soluble PD-L1 is a potential biomarker of cutaneous melanoma aggressiveness and metastasis in obstructive sleep apnea patients. Cubillos-Zapata, C., Martínez-García, M. Á., Campos-Rodríguez, F., de la Torre, M. S., Nagore, E., Martorell-Calatayud, A., Blasco, L. H., Vives, E. C., Abad-Capa, J., Montserrat, J. M., Cabriada-Nuño, V., Cano-Pumarega, I., Corral-Peñafiel, J., Diaz-Cambriles, T., Mediano, O., Somoza-González, M., Dalmau-Arias, J., Almendros, I., Farré, R., López-Collazo, E., Gozal, D., García-Río, F., & on Behalf on the Spanish Sleep Network The European Respiratory Journal, November, 2018. doi abstract bibtex Obstructive sleep apnea (OSA) up-regulates the programmed cell death-1 receptor and its ligand (PD-L1) pathway, potentially compromising immunosurveillance. We compared circulating levels of soluble PD-L1 (sPD-L1) in patients with cutaneous melanoma (CM) according to the presence and severity of OSA, and evaluated relationships with tumour aggressiveness and invasiveness.In a multicenter observational study, 360 patients with CM underwent sleep studies, and serum sPD-L1 levels were assayed by ELISA. CM aggressiveness indices included mitotic rate, Breslow index, tumour ulceration, Clark level and tumour stage, and sentinel lymph node (SLN) metastasis was recorded as a marker of invasiveness.sPD-L1 levels were higher in severe OSA compared to mild OSA or non-OSA patients. In OSA patients, sPD-L1 levels correlated with Breslow index and were higher in patients with tumour ulceration, advanced primary tumour stages or with loco-regional disease. The incorporation of sPD-L1 to the classic risk factors to SLN metastasis led to net improvements in the classification of 27.3%.Thus, sPD-L1 levels are increased in melanoma patients with severe OSA and, in addition, might serve as a potential biomarker of CM aggressiveness and invasiveness in this group of subjects.
@article{cubillos-zapata_soluble_2018,
title = {Soluble {PD}-{L}1 is a potential biomarker of cutaneous melanoma aggressiveness and metastasis in obstructive sleep apnea patients},
issn = {1399-3003},
doi = {10.1183/13993003.01298-2018},
abstract = {Obstructive sleep apnea (OSA) up-regulates the programmed cell death-1 receptor and its ligand (PD-L1) pathway, potentially compromising immunosurveillance. We compared circulating levels of soluble PD-L1 (sPD-L1) in patients with cutaneous melanoma (CM) according to the presence and severity of OSA, and evaluated relationships with tumour aggressiveness and invasiveness.In a multicenter observational study, 360 patients with CM underwent sleep studies, and serum sPD-L1 levels were assayed by ELISA. CM aggressiveness indices included mitotic rate, Breslow index, tumour ulceration, Clark level and tumour stage, and sentinel lymph node (SLN) metastasis was recorded as a marker of invasiveness.sPD-L1 levels were higher in severe OSA compared to mild OSA or non-OSA patients. In OSA patients, sPD-L1 levels correlated with Breslow index and were higher in patients with tumour ulceration, advanced primary tumour stages or with loco-regional disease. The incorporation of sPD-L1 to the classic risk factors to SLN metastasis led to net improvements in the classification of 27.3\%.Thus, sPD-L1 levels are increased in melanoma patients with severe OSA and, in addition, might serve as a potential biomarker of CM aggressiveness and invasiveness in this group of subjects.},
language = {eng},
journal = {The European Respiratory Journal},
author = {Cubillos-Zapata, Carolina and Martínez-García, Miguel Ángel and Campos-Rodríguez, Francisco and de la Torre, Manuel Sánchez and Nagore, Eduardo and Martorell-Calatayud, Antonio and Blasco, Luis Hernández and Vives, Eusebi Chiner and Abad-Capa, Jorge and Montserrat, Josep María and Cabriada-Nuño, Valentín and Cano-Pumarega, Irene and Corral-Peñafiel, Jaime and Diaz-Cambriles, Trinidad and Mediano, Olga and Somoza-González, María and Dalmau-Arias, Joan and Almendros, Isaac and Farré, Ramón and López-Collazo, Eduardo and Gozal, David and García-Río, Francisco and {on Behalf on the Spanish Sleep Network}},
month = nov,
year = {2018},
pmid = {30487198},
keywords = {Article, Pneumologia}
}
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We compared circulating levels of soluble PD-L1 (sPD-L1) in patients with cutaneous melanoma (CM) according to the presence and severity of OSA, and evaluated relationships with tumour aggressiveness and invasiveness.In a multicenter observational study, 360 patients with CM underwent sleep studies, and serum sPD-L1 levels were assayed by ELISA. CM aggressiveness indices included mitotic rate, Breslow index, tumour ulceration, Clark level and tumour stage, and sentinel lymph node (SLN) metastasis was recorded as a marker of invasiveness.sPD-L1 levels were higher in severe OSA compared to mild OSA or non-OSA patients. In OSA patients, sPD-L1 levels correlated with Breslow index and were higher in patients with tumour ulceration, advanced primary tumour stages or with loco-regional disease. 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We compared circulating levels of soluble PD-L1 (sPD-L1) in patients with cutaneous melanoma (CM) according to the presence and severity of OSA, and evaluated relationships with tumour aggressiveness and invasiveness.In a multicenter observational study, 360 patients with CM underwent sleep studies, and serum sPD-L1 levels were assayed by ELISA. CM aggressiveness indices included mitotic rate, Breslow index, tumour ulceration, Clark level and tumour stage, and sentinel lymph node (SLN) metastasis was recorded as a marker of invasiveness.sPD-L1 levels were higher in severe OSA compared to mild OSA or non-OSA patients. In OSA patients, sPD-L1 levels correlated with Breslow index and were higher in patients with tumour ulceration, advanced primary tumour stages or with loco-regional disease. 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