CGRP stimulates gill carbonic anhydrase activity in molluscs via a common CT/CGRP receptor. Cudennec, B., Rousseau, M., Lopez, E., & Fouchereau-Peron, M. Peptides, 27(11):2678-82, 11, 2006.
CGRP stimulates gill carbonic anhydrase activity in molluscs via a common CT/CGRP receptor. [pdf]Paper  CGRP stimulates gill carbonic anhydrase activity in molluscs via a common CT/CGRP receptor. [link]Website  abstract   bibtex   
The physiological significance of calcitonin gene-related peptide (CGRP) during biomineralization was investigated by assessing the effect of human CGRP on the carbonic anhydrase activity in gill membranes of the pearl oyster, Pinctada margaritifera. Salmon CT and human CGRP were able to induce a 150% increase of the basal activity. No additive effect was observed suggesting that both activities are mediated by the same receptor. The CGRP-stimulated effect was specific as demonstrated by the inhibition produced by the CGRP antagonist, hCGRP8-37. So, CGRP by its specific action on gill carbonic anhydrase controls the calcification process, an ancient role both in invertebrates and non-mammalian vertebrates.
@article{
 title = {CGRP stimulates gill carbonic anhydrase activity in molluscs via a common CT/CGRP receptor.},
 type = {article},
 year = {2006},
 identifiers = {[object Object]},
 keywords = {Animals,Calcification, Physiologic,Calcification, Physiologic: drug effects,Calcification, Physiologic: physiology,Calcitonin,Calcitonin Gene-Related Peptide,Calcitonin Gene-Related Peptide: pharmacology,Calcitonin Gene-Related Peptide: physiology,Calcitonin: pharmacology,Carbonic Anhydrases,Carbonic Anhydrases: drug effects,Carbonic Anhydrases: metabolism,Dose-Response Relationship, Drug,Gills,Gills: drug effects,Gills: enzymology,Humans,Peptide Fragments,Peptide Fragments: pharmacology,Peptide Fragments: physiology,Pinctada,Pinctada: drug effects,Pinctada: enzymology,Pinctada: metabolism,Receptors, Calcitonin Gene-Related Peptide,Receptors, Calcitonin Gene-Related Peptide: metabo,Salmon,Time Factors},
 pages = {2678-82},
 volume = {27},
 websites = {http://www.ncbi.nlm.nih.gov/pubmed/16797782},
 month = {11},
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 abstract = {The physiological significance of calcitonin gene-related peptide (CGRP) during biomineralization was investigated by assessing the effect of human CGRP on the carbonic anhydrase activity in gill membranes of the pearl oyster, Pinctada margaritifera. Salmon CT and human CGRP were able to induce a 150% increase of the basal activity. No additive effect was observed suggesting that both activities are mediated by the same receptor. The CGRP-stimulated effect was specific as demonstrated by the inhibition produced by the CGRP antagonist, hCGRP8-37. So, CGRP by its specific action on gill carbonic anhydrase controls the calcification process, an ancient role both in invertebrates and non-mammalian vertebrates.},
 bibtype = {article},
 author = {Cudennec, Benoit and Rousseau, Marthe and Lopez, Evelyne and Fouchereau-Peron, Martine},
 journal = {Peptides},
 number = {11}
}
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