@article{cui_effects_2018,
	title = {Effects and {Tolerance} of {Protein} and {Energy}-{Enriched} {Formula} in {Infants} {Following} {Congenital} {Heart} {Surgery}: {A} {Randomized} {Controlled} {Trial}.},
	volume = {42},
	url = {https://app.readcube.com/library/d55a0da2-06b3-4d90-8ff1-3099d227a5b8/item/b90bcae8-65be-4c41-9a49-31d76c335d07},
	doi = {10.1002/jpen.1031},
	abstract = {BACKGROUND:Nutrition support is important for clinical management to improve outcomes of infants following congenital heart surgery. Protein-enriched and energy-enriched formula (PE-formula) may help provide adequate nutrition and promote wound healing. However, the effects and tolerance of increased protein and energy intakes of these infants have not been well defined.

OBJECTIVE:To evaluate nutrition effects and tolerance of a PE-formula compared with the standard formula (S-formula) in infants in the first 5 days after congenital heart surgery.

METHODS:Fifty infants were randomly assigned to S-formula (S-group, n = 24) or PE-formula (PE-group, n = 26). Daily nutrient intakes and tolerance were recorded. Plasma amino acid concentrations were measured. Cumulative energy balance and nitrogen balance were calculated.

RESULTS:Nutrient intakes were significantly higher in the PE-group after day 1, and all met the adequate intakes as early as day 2. Nitrogen balance in the PE-group met positive balance from day 2, whereas in the S-group, this was not until day 5. The PE-group also had a significantly higher increase in many essential amino acids. With the exception of tolerable diarrhea (multivariate adjusted hazard ratio, 3.16; 95\% confidence interval, 1.24-8.01), the PE-group did not have a significantly higher incidence of intolerable events.

CONCLUSIONS:In infants during the early postoperative period after congenital heart surgery, early administration of PE-formula was as well tolerated as S-formula and effective in achieving higher nutrition intakes and earlier nitrogen balance. Further research is warranted to support the use of PE-formula in this special group of infants.},
	language = {English},
	number = {1},
	journal = {JPEN. Journal of parenteral and enteral nutrition},
	author = {Cui, Yanqin and Li, Lijuan and Hu, Chunmei and Shi, Hui and Li, Jianbin and Gupta, Ramit Kumar and Liang, Huiying and Chen, Xinxin and Gong, Sitang},
	month = jan,
	year = {2018},
	pages = {196 -- 204},
}

{"_id":"aWaHxJ446wMS8YSZt","bibbaseid":"cui-li-hu-shi-li-gupta-liang-chen-etal-effectsandtoleranceofproteinandenergyenrichedformulaininfantsfollowingcongenitalheartsurgeryarandomizedcontrolledtrial-2018","authorIDs":[],"author_short":["Cui, Y.","Li, L.","Hu, C.","Shi, H.","Li, J.","Gupta, R. K.","Liang, H.","Chen, X.","Gong, S."],"bibdata":{"bibtype":"article","type":"article","title":"Effects and Tolerance of Protein and Energy-Enriched Formula in Infants Following Congenital Heart Surgery: A Randomized Controlled Trial.","volume":"42","url":"https://app.readcube.com/library/d55a0da2-06b3-4d90-8ff1-3099d227a5b8/item/b90bcae8-65be-4c41-9a49-31d76c335d07","doi":"10.1002/jpen.1031","abstract":"BACKGROUND:Nutrition support is important for clinical management to improve outcomes of infants following congenital heart surgery. Protein-enriched and energy-enriched formula (PE-formula) may help provide adequate nutrition and promote wound healing. However, the effects and tolerance of increased protein and energy intakes of these infants have not been well defined. OBJECTIVE:To evaluate nutrition effects and tolerance of a PE-formula compared with the standard formula (S-formula) in infants in the first 5 days after congenital heart surgery. METHODS:Fifty infants were randomly assigned to S-formula (S-group, n = 24) or PE-formula (PE-group, n = 26). Daily nutrient intakes and tolerance were recorded. Plasma amino acid concentrations were measured. Cumulative energy balance and nitrogen balance were calculated. RESULTS:Nutrient intakes were significantly higher in the PE-group after day 1, and all met the adequate intakes as early as day 2. Nitrogen balance in the PE-group met positive balance from day 2, whereas in the S-group, this was not until day 5. The PE-group also had a significantly higher increase in many essential amino acids. With the exception of tolerable diarrhea (multivariate adjusted hazard ratio, 3.16; 95% confidence interval, 1.24-8.01), the PE-group did not have a significantly higher incidence of intolerable events. CONCLUSIONS:In infants during the early postoperative period after congenital heart surgery, early administration of PE-formula was as well tolerated as S-formula and effective in achieving higher nutrition intakes and earlier nitrogen balance. Further research is warranted to support the use of PE-formula in this special group of infants.","language":"English","number":"1","journal":"JPEN. Journal of parenteral and enteral nutrition","author":[{"propositions":[],"lastnames":["Cui"],"firstnames":["Yanqin"],"suffixes":[]},{"propositions":[],"lastnames":["Li"],"firstnames":["Lijuan"],"suffixes":[]},{"propositions":[],"lastnames":["Hu"],"firstnames":["Chunmei"],"suffixes":[]},{"propositions":[],"lastnames":["Shi"],"firstnames":["Hui"],"suffixes":[]},{"propositions":[],"lastnames":["Li"],"firstnames":["Jianbin"],"suffixes":[]},{"propositions":[],"lastnames":["Gupta"],"firstnames":["Ramit","Kumar"],"suffixes":[]},{"propositions":[],"lastnames":["Liang"],"firstnames":["Huiying"],"suffixes":[]},{"propositions":[],"lastnames":["Chen"],"firstnames":["Xinxin"],"suffixes":[]},{"propositions":[],"lastnames":["Gong"],"firstnames":["Sitang"],"suffixes":[]}],"month":"January","year":"2018","pages":"196 – 204","bibtex":"@article{cui_effects_2018,\n\ttitle = {Effects and {Tolerance} of {Protein} and {Energy}-{Enriched} {Formula} in {Infants} {Following} {Congenital} {Heart} {Surgery}: {A} {Randomized} {Controlled} {Trial}.},\n\tvolume = {42},\n\turl = {https://app.readcube.com/library/d55a0da2-06b3-4d90-8ff1-3099d227a5b8/item/b90bcae8-65be-4c41-9a49-31d76c335d07},\n\tdoi = {10.1002/jpen.1031},\n\tabstract = {BACKGROUND:Nutrition support is important for clinical management to improve outcomes of infants following congenital heart surgery. Protein-enriched and energy-enriched formula (PE-formula) may help provide adequate nutrition and promote wound healing. However, the effects and tolerance of increased protein and energy intakes of these infants have not been well defined.\n\nOBJECTIVE:To evaluate nutrition effects and tolerance of a PE-formula compared with the standard formula (S-formula) in infants in the first 5 days after congenital heart surgery.\n\nMETHODS:Fifty infants were randomly assigned to S-formula (S-group, n = 24) or PE-formula (PE-group, n = 26). Daily nutrient intakes and tolerance were recorded. Plasma amino acid concentrations were measured. Cumulative energy balance and nitrogen balance were calculated.\n\nRESULTS:Nutrient intakes were significantly higher in the PE-group after day 1, and all met the adequate intakes as early as day 2. Nitrogen balance in the PE-group met positive balance from day 2, whereas in the S-group, this was not until day 5. The PE-group also had a significantly higher increase in many essential amino acids. With the exception of tolerable diarrhea (multivariate adjusted hazard ratio, 3.16; 95\\% confidence interval, 1.24-8.01), the PE-group did not have a significantly higher incidence of intolerable events.\n\nCONCLUSIONS:In infants during the early postoperative period after congenital heart surgery, early administration of PE-formula was as well tolerated as S-formula and effective in achieving higher nutrition intakes and earlier nitrogen balance. Further research is warranted to support the use of PE-formula in this special group of infants.},\n\tlanguage = {English},\n\tnumber = {1},\n\tjournal = {JPEN. Journal of parenteral and enteral nutrition},\n\tauthor = {Cui, Yanqin and Li, Lijuan and Hu, Chunmei and Shi, Hui and Li, Jianbin and Gupta, Ramit Kumar and Liang, Huiying and Chen, Xinxin and Gong, Sitang},\n\tmonth = jan,\n\tyear = {2018},\n\tpages = {196 -- 204},\n}\n\n\n\n","author_short":["Cui, Y.","Li, L.","Hu, C.","Shi, H.","Li, J.","Gupta, R. K.","Liang, H.","Chen, X.","Gong, S."],"key":"cui_effects_2018","id":"cui_effects_2018","bibbaseid":"cui-li-hu-shi-li-gupta-liang-chen-etal-effectsandtoleranceofproteinandenergyenrichedformulaininfantsfollowingcongenitalheartsurgeryarandomizedcontrolledtrial-2018","role":"author","urls":{"Paper":"https://app.readcube.com/library/d55a0da2-06b3-4d90-8ff1-3099d227a5b8/item/b90bcae8-65be-4c41-9a49-31d76c335d07"},"metadata":{"authorlinks":{}},"downloads":0,"html":""},"bibtype":"article","biburl":"http://bibbase.org/zotero-group/gxu917/1345589","creationDate":"2020-08-14T16:36:39.815Z","downloads":0,"keywords":[],"search_terms":["effects","tolerance","protein","energy","enriched","formula","infants","following","congenital","heart","surgery","randomized","controlled","trial","cui","li","hu","shi","li","gupta","liang","chen","gong"],"title":"Effects and Tolerance of Protein and Energy-Enriched Formula in Infants Following Congenital Heart Surgery: A Randomized Controlled Trial.","year":2018,"dataSources":["4P4hKw3sZj97Zz2kx"]}