Combination of radiofrequency ablation and sequential cellular immunotherapy improves progression-free survival for patients with hepatocellular carcinoma. Cui, J., Wang, N., Zhao, H., Jin, H., Wang, G., Niu, C., Terunuma, H., He, H., & Li, W. International Journal of Cancer, 134(2):342–351. ![Combination of radiofrequency ablation and sequential cellular immunotherapy improves progression-free survival for patients with hepatocellular carcinoma [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Hepatocellular carcinoma (HCC) recurs frequently after minimally invasive therapy. The aim of our study was to observe the efficiency and safety of the combined treatment of radiofrequency ablation (RFA) with cellular immunotherapy (CIT) for HCC patients. In our study, 62 patients with HCC who were treated with radical RFA were divided into two groups: RFA alone (32 patients) and RFA/CIT (30 patients). Autologous mononuclear cells were collected from the peripheral blood and separated by apheresis, and then induced into natural killer (NK) cells, γδT cells and cytokine-induced killer (CIK) cells. These cells were identified by flow cytometry with their specific antibodies and then were infused intravenously to RFA/CIT patients for three or six courses. The tumor recurrent status of these patients was evaluated with computed tomography or magnetic resonance imaging every 3 months after RFA. Progression-free survival (PFS), liver function, viral load and adverse effects were examined. The results implied that PFS was higher in RFA/CIT group than that in RFA group. In RFA/CIT group, six courses had better survival prognosis than three courses. Viral load of hepatitis C was decreased in two of three patients without antiviral therapy in RFA/CIT group, but was increased in RFA group. No significant adverse reaction was found in the patients with CIT. In summary, these preliminary results suggest that combination of sequential CIT with RFA for HCC patients was efficient and safe, and may be helpful in the prevention of the recurrence for the patients with HCC after RFA.
@article{cui_combination_nodate,
title = {Combination of radiofrequency ablation and sequential cellular immunotherapy improves progression-free survival for patients with hepatocellular carcinoma},
volume = {134},
copyright = {© 2013 UICC},
issn = {1097-0215},
url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.28372},
doi = {10.1002/ijc.28372},
abstract = {Hepatocellular carcinoma (HCC) recurs frequently after minimally invasive therapy. The aim of our study was to observe the efficiency and safety of the combined treatment of radiofrequency ablation (RFA) with cellular immunotherapy (CIT) for HCC patients. In our study, 62 patients with HCC who were treated with radical RFA were divided into two groups: RFA alone (32 patients) and RFA/CIT (30 patients). Autologous mononuclear cells were collected from the peripheral blood and separated by apheresis, and then induced into natural killer (NK) cells, γδT cells and cytokine-induced killer (CIK) cells. These cells were identified by flow cytometry with their specific antibodies and then were infused intravenously to RFA/CIT patients for three or six courses. The tumor recurrent status of these patients was evaluated with computed tomography or magnetic resonance imaging every 3 months after RFA. Progression-free survival (PFS), liver function, viral load and adverse effects were examined. The results implied that PFS was higher in RFA/CIT group than that in RFA group. In RFA/CIT group, six courses had better survival prognosis than three courses. Viral load of hepatitis C was decreased in two of three patients without antiviral therapy in RFA/CIT group, but was increased in RFA group. No significant adverse reaction was found in the patients with CIT. In summary, these preliminary results suggest that combination of sequential CIT with RFA for HCC patients was efficient and safe, and may be helpful in the prevention of the recurrence for the patients with HCC after RFA.},
language = {en},
number = {2},
urldate = {2018-07-07},
journal = {International Journal of Cancer},
author = {Cui, Jiuwei and Wang, Nanya and Zhao, Hengjun and Jin, Haofan and Wang, Guanjun and Niu, Chao and Terunuma, Hiroshi and He, Hua and Li, Wei},
keywords = {cellular immunotherapy, hepatocellular carcinoma, radiofrequency ablation},
pages = {342--351},
}
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The aim of our study was to observe the efficiency and safety of the combined treatment of radiofrequency ablation (RFA) with cellular immunotherapy (CIT) for HCC patients. In our study, 62 patients with HCC who were treated with radical RFA were divided into two groups: RFA alone (32 patients) and RFA/CIT (30 patients). Autologous mononuclear cells were collected from the peripheral blood and separated by apheresis, and then induced into natural killer (NK) cells, γδT cells and cytokine-induced killer (CIK) cells. These cells were identified by flow cytometry with their specific antibodies and then were infused intravenously to RFA/CIT patients for three or six courses. The tumor recurrent status of these patients was evaluated with computed tomography or magnetic resonance imaging every 3 months after RFA. Progression-free survival (PFS), liver function, viral load and adverse effects were examined. The results implied that PFS was higher in RFA/CIT group than that in RFA group. In RFA/CIT group, six courses had better survival prognosis than three courses. Viral load of hepatitis C was decreased in two of three patients without antiviral therapy in RFA/CIT group, but was increased in RFA group. No significant adverse reaction was found in the patients with CIT. In summary, these preliminary results suggest that combination of sequential CIT with RFA for HCC patients was efficient and safe, and may be helpful in the prevention of the recurrence for the patients with HCC after RFA.","language":"en","number":"2","urldate":"2018-07-07","journal":"International Journal of Cancer","author":[{"propositions":[],"lastnames":["Cui"],"firstnames":["Jiuwei"],"suffixes":[]},{"propositions":[],"lastnames":["Wang"],"firstnames":["Nanya"],"suffixes":[]},{"propositions":[],"lastnames":["Zhao"],"firstnames":["Hengjun"],"suffixes":[]},{"propositions":[],"lastnames":["Jin"],"firstnames":["Haofan"],"suffixes":[]},{"propositions":[],"lastnames":["Wang"],"firstnames":["Guanjun"],"suffixes":[]},{"propositions":[],"lastnames":["Niu"],"firstnames":["Chao"],"suffixes":[]},{"propositions":[],"lastnames":["Terunuma"],"firstnames":["Hiroshi"],"suffixes":[]},{"propositions":[],"lastnames":["He"],"firstnames":["Hua"],"suffixes":[]},{"propositions":[],"lastnames":["Li"],"firstnames":["Wei"],"suffixes":[]}],"keywords":"cellular immunotherapy, hepatocellular carcinoma, radiofrequency ablation","pages":"342–351","bibtex":"@article{cui_combination_nodate,\n\ttitle = {Combination of radiofrequency ablation and sequential cellular immunotherapy improves progression-free survival for patients with hepatocellular carcinoma},\n\tvolume = {134},\n\tcopyright = {© 2013 UICC},\n\tissn = {1097-0215},\n\turl = {https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.28372},\n\tdoi = {10.1002/ijc.28372},\n\tabstract = {Hepatocellular carcinoma (HCC) recurs frequently after minimally invasive therapy. The aim of our study was to observe the efficiency and safety of the combined treatment of radiofrequency ablation (RFA) with cellular immunotherapy (CIT) for HCC patients. In our study, 62 patients with HCC who were treated with radical RFA were divided into two groups: RFA alone (32 patients) and RFA/CIT (30 patients). Autologous mononuclear cells were collected from the peripheral blood and separated by apheresis, and then induced into natural killer (NK) cells, γδT cells and cytokine-induced killer (CIK) cells. These cells were identified by flow cytometry with their specific antibodies and then were infused intravenously to RFA/CIT patients for three or six courses. The tumor recurrent status of these patients was evaluated with computed tomography or magnetic resonance imaging every 3 months after RFA. Progression-free survival (PFS), liver function, viral load and adverse effects were examined. The results implied that PFS was higher in RFA/CIT group than that in RFA group. In RFA/CIT group, six courses had better survival prognosis than three courses. Viral load of hepatitis C was decreased in two of three patients without antiviral therapy in RFA/CIT group, but was increased in RFA group. No significant adverse reaction was found in the patients with CIT. In summary, these preliminary results suggest that combination of sequential CIT with RFA for HCC patients was efficient and safe, and may be helpful in the prevention of the recurrence for the patients with HCC after RFA.},\n\tlanguage = {en},\n\tnumber = {2},\n\turldate = {2018-07-07},\n\tjournal = {International Journal of Cancer},\n\tauthor = {Cui, Jiuwei and Wang, Nanya and Zhao, Hengjun and Jin, Haofan and Wang, Guanjun and Niu, Chao and Terunuma, Hiroshi and He, Hua and Li, Wei},\n\tkeywords = {cellular immunotherapy, hepatocellular carcinoma, radiofrequency ablation},\n\tpages = {342--351},\n}\n\n","author_short":["Cui, J.","Wang, N.","Zhao, H.","Jin, H.","Wang, G.","Niu, C.","Terunuma, H.","He, H.","Li, W."],"key":"cui_combination_nodate","id":"cui_combination_nodate","bibbaseid":"cui-wang-zhao-jin-wang-niu-terunuma-he-etal-combinationofradiofrequencyablationandsequentialcellularimmunotherapyimprovesprogressionfreesurvivalforpatientswithhepatocellularcarcinoma","role":"author","urls":{"Paper":"https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.28372"},"keyword":["cellular immunotherapy","hepatocellular carcinoma","radiofrequency ablation"],"metadata":{"authorlinks":{}},"html":""},"search_terms":["combination","radiofrequency","ablation","sequential","cellular","immunotherapy","improves","progression","free","survival","patients","hepatocellular","carcinoma","cui","wang","zhao","jin","wang","niu","terunuma","he","li"],"keywords":["cellular immunotherapy","hepatocellular carcinoma","radiofrequency ablation"],"authorIDs":[],"dataSources":["JPAoq8b4ppzXj5XYZ"]}