@article{dai_polyethylene_2014,
	title = {Polyethylene {Glycol} {Backfilling} {Mitigates} the {Negative} {Impact} of the {Protein} {Corona} on {Nanoparticle} {Cell} {Targeting}},
	volume = {53},
	issn = {1521-3773},
	url = {http://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201309464},
	doi = {10.1002/anie.201309464},
	abstract = {In protein-rich environments such as the blood, the formation of a protein corona on receptor-targeting nanoparticles prevents target recognition. As a result, the ability of targeted nanoparticles to selectively bind to diseased cells is drastically inhibited. Backfilling the surface of a targeted nanoparticle with polyethylene glycol (PEG) molecules is demonstrated to reduce the formation of the protein corona and re-establishes specific binding. The length of the backfilled PEG molecules must be less than the length of the ligand linker; otherwise, PEG interferes with the binding of the targeting ligand to its corresponding cellular receptor.},
	language = {en},
	number = {20},
	urldate = {2021-11-06},
	journal = {Angewandte Chemie International Edition},
	author = {Dai, Qin and Walkey, Carl and Chan, Warren C. W.},
	year = {2014},
	note = {\_eprint: https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201309464},
	keywords = {cell targeting, nanoparticles, PEGylation, polymers, surface chemistry},
	pages = {5093--5096},
	file = {Full Text PDF:files/2025/Dai et al. - 2014 - Polyethylene Glycol Backfilling Mitigates the Nega.pdf:application/pdf;Snapshot:files/2029/anie.html:text/html},
	url_Paper = {https://inbs.med.utoronto.ca/wp-content/uploads/2020/08/anie.201309464.pdf}
}

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