Ministernotomy Versus Full Sternotomy Aortic Valve Replacement With a Sutureless Bioprosthesis: A Multicenter Study. Dalén, M.; Biancari, F.; Rubino, A. S.; Santarpino, G.; De Praetere, H.; Kasama, K.; Juvonen, T.; Deste, W.; Pollari, F.; Meuris, B.; Fischlein, T.; Mignosa, C.; Gatti, G.; Pappalardo, A.; Sartipy, U.; and Svenarud, P. The Annals of Thoracic Surgery, December, 2014.
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BACKGROUND: The aim of this study was to analyze early postoperative outcomes and 2-year survival after aortic valve replacement (AVR) with the sutureless Perceval bioprosthesis (Sorin Biomedica Cardio Srl, Salluggia, Italy) performed through ministernotomy compared with full sternotomy. METHODS: This was a study of 267 consecutive patients who underwent isolated AVR with the sutureless Perceval bioprosthesis between 2007 and 2014 at 6 European centers. Of these, 189 (70.8%) were performed through ministernotomy and 78 through a full sternotomy. Propensity score matching was used to reduce selection bias. RESULTS: In the overall cohort of ministernotomy and full sternotomy patients, in-hospital mortality was 1.1% and 2.6% and 2-year survival was 92% and 91%, respectively. Propensity score matching resulted in 56 pairs with similar characteristics and operative risk. Aortic cross-clamp (44 minutes in both groups, p = 0.931) and cardiopulmonary bypass time (69 vs 74 minutes, p = 0.363) did not differ between the groups. Apart from higher values in the ministernotomy group for postoperative peak gradients (28.1 vs 23.3 mm Hg, p = 0.026) and mean aortic valve gradients (15.2 vs 11.7 mm Hg, p = 0.011), early postoperative outcomes did not differ in the propensity-matched cohort. There were no differences in the in-hospital mortality rate or 2-year survival between the groups. CONCLUSIONS: AVR with the sutureless Perceval bioprosthesis through a ministernotomy was a safe and reproducible procedure that was not associated with prolonged aortic cross-clamp or cardiopulmonary bypass time compared with a full sternotomy. Early postoperative outcomes and 2-year survival were comparable between patients undergoing ministernotomy and full sternotomy.
@article{dalen_ministernotomy_2014,
	title = {Ministernotomy {Versus} {Full} {Sternotomy} {Aortic} {Valve} {Replacement} {With} a {Sutureless} {Bioprosthesis}: {A} {Multicenter} {Study}},
	issn = {1552-6259},
	shorttitle = {Ministernotomy {Versus} {Full} {Sternotomy} {Aortic} {Valve} {Replacement} {With} a {Sutureless} {Bioprosthesis}},
	doi = {10.1016/j.athoracsur.2014.08.028},
	abstract = {BACKGROUND: The aim of this study was to analyze early postoperative outcomes and 2-year survival after aortic valve replacement (AVR) with the sutureless Perceval bioprosthesis (Sorin Biomedica Cardio Srl, Salluggia, Italy) performed through ministernotomy compared with full sternotomy.
METHODS: This was a study of 267 consecutive patients who underwent isolated AVR with the sutureless Perceval bioprosthesis between 2007 and 2014 at 6 European centers. Of these, 189 (70.8\%) were performed through ministernotomy and 78 through a full sternotomy. Propensity score matching was used to reduce selection bias.
RESULTS: In the overall cohort of ministernotomy and full sternotomy patients, in-hospital mortality was 1.1\% and 2.6\% and 2-year survival was 92\% and 91\%, respectively. Propensity score matching resulted in 56 pairs with similar characteristics and operative risk. Aortic cross-clamp (44 minutes in both groups, p = 0.931) and cardiopulmonary bypass time (69 vs 74 minutes, p = 0.363) did not differ between the groups. Apart from higher values in the ministernotomy group for postoperative peak gradients (28.1 vs 23.3 mm Hg, p = 0.026) and mean aortic valve gradients (15.2 vs 11.7 mm Hg, p = 0.011), early postoperative outcomes did not differ in the propensity-matched cohort. There were no differences in the in-hospital mortality rate or 2-year survival between the groups.
CONCLUSIONS: AVR with the sutureless Perceval bioprosthesis through a ministernotomy was a safe and reproducible procedure that was not associated with prolonged aortic cross-clamp or cardiopulmonary bypass time compared with a full sternotomy. Early postoperative outcomes and 2-year survival were comparable between patients undergoing ministernotomy and full sternotomy.},
	language = {ENG},
	journal = {The Annals of Thoracic Surgery},
	author = {Dalén, Magnus and Biancari, Fausto and Rubino, Antonino S. and Santarpino, Giuseppe and De Praetere, Herbert and Kasama, Keiichiro and Juvonen, Tatu and Deste, Wanda and Pollari, Francesco and Meuris, Bart and Fischlein, Theodor and Mignosa, Carmelo and Gatti, Giuseppe and Pappalardo, Aniello and Sartipy, Ulrik and Svenarud, Peter},
	month = dec,
	year = {2014},
	pmid = {25483001}
}
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