@ARTICLE{Dammerman2000-yv,
  title    = "An excitatory {GABAergic} plexus in developing neocortical layer
              1",
  author   = "Dammerman, R S and Flint, A C and Noctor, S and Kriegstein, A R",
  abstract = "Layer 1 of the developing rodent somatosensory cortex contains a
              dense, transient GABAergic fiber plexus. Axons arising from the
              zona incerta (ZI) of the ventral thalamus contribute to this
              plexus, as do axons of intrinsic GABAergic cells of layer 1. The
              function of this early-appearing fiber plexus is not known, but
              these fibers are positioned to contact the apical dendrites of
              most postmigratory neurons. Here we show that electrical
              stimulation of layer 1 results in a GABA(A)-mediated postsynaptic
              current (PSC) in pyramidal neurons. Gramicidin perforated patch
              recording demonstrates that the GABAergic layer 1 synapse is
              excitatory and can trigger action potentials in cortical neurons.
              In contrast to electrical stimulation, activation of intrinsic
              layer 1 neurons with a glutamate agonist fails to produce PSCs in
              pyramidal cells. In addition, responses can be evoked by
              stimulation of layer 1 at relatively large distances from the
              recording site. These findings are consistent with a contribution
              of the widely projecting incertocortical pathway, the only
              described GABAergic projection to neonatal cortex. Recording of
              identified neonatal incertocortical neurons reveals a population
              of active cells that exhibit high frequencies of spontaneous
              action potentials and are capable of robustly activating neonatal
              cortical neurons. Because the fiber plexus is confined to layer
              1, this pathway provides a spatially restricted excitatory
              GABAergic innervation of the distal apical dendrites of pyramidal
              neurons during the peak period of cortical synaptogenesis.",
  journal  = "J Neurophysiol",
  volume   =  84,
  number   =  1,
  pages    = "428--434",
  month    =  jul,
  year     =  2000,
  address  = "United States",
  language = "en"
}

{"_id":"9RDZqvQBznKwtSbyL","bibbaseid":"dammerman-flint-noctor-kriegstein-anexcitatorygabaergicplexusindevelopingneocorticallayer1-2000","author_short":["Dammerman, R S","Flint, A C","Noctor, S","Kriegstein, A R"],"bibdata":{"bibtype":"article","type":"article","title":"An excitatory GABAergic plexus in developing neocortical layer 1","author":[{"propositions":[],"lastnames":["Dammerman"],"firstnames":["R","S"],"suffixes":[]},{"propositions":[],"lastnames":["Flint"],"firstnames":["A","C"],"suffixes":[]},{"propositions":[],"lastnames":["Noctor"],"firstnames":["S"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["A","R"],"suffixes":[]}],"abstract":"Layer 1 of the developing rodent somatosensory cortex contains a dense, transient GABAergic fiber plexus. Axons arising from the zona incerta (ZI) of the ventral thalamus contribute to this plexus, as do axons of intrinsic GABAergic cells of layer 1. The function of this early-appearing fiber plexus is not known, but these fibers are positioned to contact the apical dendrites of most postmigratory neurons. Here we show that electrical stimulation of layer 1 results in a GABA(A)-mediated postsynaptic current (PSC) in pyramidal neurons. Gramicidin perforated patch recording demonstrates that the GABAergic layer 1 synapse is excitatory and can trigger action potentials in cortical neurons. In contrast to electrical stimulation, activation of intrinsic layer 1 neurons with a glutamate agonist fails to produce PSCs in pyramidal cells. In addition, responses can be evoked by stimulation of layer 1 at relatively large distances from the recording site. These findings are consistent with a contribution of the widely projecting incertocortical pathway, the only described GABAergic projection to neonatal cortex. Recording of identified neonatal incertocortical neurons reveals a population of active cells that exhibit high frequencies of spontaneous action potentials and are capable of robustly activating neonatal cortical neurons. Because the fiber plexus is confined to layer 1, this pathway provides a spatially restricted excitatory GABAergic innervation of the distal apical dendrites of pyramidal neurons during the peak period of cortical synaptogenesis.","journal":"J Neurophysiol","volume":"84","number":"1","pages":"428–434","month":"July","year":"2000","address":"United States","language":"en","bibtex":"@ARTICLE{Dammerman2000-yv,\n title = \"An excitatory {GABAergic} plexus in developing neocortical layer\n 1\",\n author = \"Dammerman, R S and Flint, A C and Noctor, S and Kriegstein, A R\",\n abstract = \"Layer 1 of the developing rodent somatosensory cortex contains a\n dense, transient GABAergic fiber plexus. Axons arising from the\n zona incerta (ZI) of the ventral thalamus contribute to this\n plexus, as do axons of intrinsic GABAergic cells of layer 1. The\n function of this early-appearing fiber plexus is not known, but\n these fibers are positioned to contact the apical dendrites of\n most postmigratory neurons. Here we show that electrical\n stimulation of layer 1 results in a GABA(A)-mediated postsynaptic\n current (PSC) in pyramidal neurons. Gramicidin perforated patch\n recording demonstrates that the GABAergic layer 1 synapse is\n excitatory and can trigger action potentials in cortical neurons.\n In contrast to electrical stimulation, activation of intrinsic\n layer 1 neurons with a glutamate agonist fails to produce PSCs in\n pyramidal cells. In addition, responses can be evoked by\n stimulation of layer 1 at relatively large distances from the\n recording site. These findings are consistent with a contribution\n of the widely projecting incertocortical pathway, the only\n described GABAergic projection to neonatal cortex. Recording of\n identified neonatal incertocortical neurons reveals a population\n of active cells that exhibit high frequencies of spontaneous\n action potentials and are capable of robustly activating neonatal\n cortical neurons. Because the fiber plexus is confined to layer\n 1, this pathway provides a spatially restricted excitatory\n GABAergic innervation of the distal apical dendrites of pyramidal\n neurons during the peak period of cortical synaptogenesis.\",\n journal = \"J Neurophysiol\",\n volume = 84,\n number = 1,\n pages = \"428--434\",\n month = jul,\n year = 2000,\n address = \"United States\",\n language = \"en\"\n}\n\n","author_short":["Dammerman, R S","Flint, A C","Noctor, S","Kriegstein, A R"],"key":"Dammerman2000-yv","id":"Dammerman2000-yv","bibbaseid":"dammerman-flint-noctor-kriegstein-anexcitatorygabaergicplexusindevelopingneocorticallayer1-2000","role":"author","urls":{},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/EJMp3HRuxirjxpcXh/references.bib","dataSources":["sAFYeB74DpbdXM9NN","4zx9n2tbeLTix3Wxr","k3cdWrThyTh5o59Rm","hq9pebjzmsTuyxGGx","h8Atv2SAy4PmShg5j"],"keywords":[],"search_terms":["excitatory","gabaergic","plexus","developing","neocortical","layer","dammerman","flint","noctor","kriegstein"],"title":"An excitatory GABAergic plexus in developing neocortical layer 1","year":2000}