@article{RN322,
   author = {Dangouloff-Ros, V. and Jansen, J. F. A. and de Jong, J. and Postma, A. A. and Hoeberigs, C. and Fillon, L. and Boisgontier, J. and Roux, C. J. and Levy, R. and Varlet, P. and Blauwblomme, T. and Eisermann, M. and Losito, E. and Bourgeois, M. and Chiron, C. and Nabbout, R. and Boddaert, N. and Backes, W.},
   title = {Abnormal Spontaneous Blood Oxygenation Level Dependent Fluctuations in Children with Focal Cortical Dysplasias: Initial Findings in Surgically Confirmed Cases},
   journal = {Neuropediatrics},
   note = {Dangouloff-Ros, Volodia
Jansen, Jacobus F A
de Jong, Joost
Postma, Alida A
Hoeberigs, Christianne
Fillon, Ludovic
Boisgontier, Jennifer
Roux, Charles-Joris
Levy, Raphael
Varlet, Pascale
Blauwblomme, Thomas
Eisermann, Monika
Losito, Emma
Bourgeois, Marie
Chiron, Catherine
Nabbout, Rima
Boddaert, Nathalie
Backes, Walter
eng
Societe Francaise de Radiologie/Alain Rahmouni Research Grant/
Germany
Neuropediatrics. 2022 Dec 27. doi: 10.1055/a-1959-9241.},
   abstract = {BACKGROUND: Focal cortical dysplasias (FCD) are a frequent cause of drug-resistant epilepsy in children but are often undetected on structural magnetic resonance imaging (MRI). We aimed to measure and validate the variation of resting state functional MRI (rs-fMRI) blood oxygenation level dependent (BOLD) metrics in surgically proven FCDs in children, to assess the potential yield for detecting and understanding these lesions. METHODS: We prospectively included pediatric patients with surgically proven FCD with inconclusive structural MRI and healthy controls, who underwent a ten-minute rs-fMRI acquired at 3T. Rs-fMRI data was pre-processed and maps of values of regional homogeneity (ReHo), degree centrality (DC), amplitude of low frequency fluctuations (ALFF) and fractional ALFF (fALFF) were calculated. The variations of BOLD metrics within the to-be-resected areas were analyzed visually, and quantitatively using lateralization indices. BOLD metrics variations were also analyzed in fluorodeoxyglucose-positron emission tomography (FDG-PET) hypometabolic areas. RESULTS: We included 7 patients (range: 3-15 years) and 6 aged-matched controls (range: 6-17 years). ReHo lateralization indices were positive in the to-be-resected areas in 4/7 patients, and in 6/7 patients in the additional PET hypometabolic areas. These indices were significantly higher compared to controls in 3/7 and 4/7 patients, respectively. Visual analysis revealed a good spatial correlation between high ReHo areas and MRI structural abnormalities (when present) or PET hypometabolic areas. No consistent variation was seen using DC, ALFF, or fALFF. CONCLUSION: Resting-state fMRI metrics, noticeably increase in ReHo, may have potential to help detect MRI-negative FCDs in combination with other morphological and functional techniques, used in clinical practice and epilepsy-surgery screening.},
   ISSN = {1439-1899 (Electronic)
0174-304X (Linking)},
   DOI = {10.1055/a-1959-9241},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/36223876},
   year = {2022},
   type = {Journal Article}
}

{"_id":"KM2p33GEKJeqMpjqM","bibbaseid":"dangouloffros-jansen-dejong-postma-hoeberigs-fillon-boisgontier-roux-etal-abnormalspontaneousbloodoxygenationleveldependentfluctuationsinchildrenwithfocalcorticaldysplasiasinitialfindingsinsurgicallyconfirmedcases-2022","author_short":["Dangouloff-Ros, V.","Jansen, J. F. A.","de Jong, J.","Postma, A. A.","Hoeberigs, C.","Fillon, L.","Boisgontier, J.","Roux, C. J.","Levy, R.","Varlet, P.","Blauwblomme, T.","Eisermann, M.","Losito, E.","Bourgeois, M.","Chiron, C.","Nabbout, R.","Boddaert, N.","Backes, W."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Dangouloff-Ros"],"firstnames":["V."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]},{"propositions":["de"],"lastnames":["Jong"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Postma"],"firstnames":["A.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Hoeberigs"],"firstnames":["C."],"suffixes":[]},{"propositions":[],"lastnames":["Fillon"],"firstnames":["L."],"suffixes":[]},{"propositions":[],"lastnames":["Boisgontier"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Roux"],"firstnames":["C.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Levy"],"firstnames":["R."],"suffixes":[]},{"propositions":[],"lastnames":["Varlet"],"firstnames":["P."],"suffixes":[]},{"propositions":[],"lastnames":["Blauwblomme"],"firstnames":["T."],"suffixes":[]},{"propositions":[],"lastnames":["Eisermann"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Losito"],"firstnames":["E."],"suffixes":[]},{"propositions":[],"lastnames":["Bourgeois"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Chiron"],"firstnames":["C."],"suffixes":[]},{"propositions":[],"lastnames":["Nabbout"],"firstnames":["R."],"suffixes":[]},{"propositions":[],"lastnames":["Boddaert"],"firstnames":["N."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W."],"suffixes":[]}],"title":"Abnormal Spontaneous Blood Oxygenation Level Dependent Fluctuations in Children with Focal Cortical Dysplasias: Initial Findings in Surgically Confirmed Cases","journal":"Neuropediatrics","note":"Dangouloff-Ros, Volodia Jansen, Jacobus F A de Jong, Joost Postma, Alida A Hoeberigs, Christianne Fillon, Ludovic Boisgontier, Jennifer Roux, Charles-Joris Levy, Raphael Varlet, Pascale Blauwblomme, Thomas Eisermann, Monika Losito, Emma Bourgeois, Marie Chiron, Catherine Nabbout, Rima Boddaert, Nathalie Backes, Walter eng Societe Francaise de Radiologie/Alain Rahmouni Research Grant/ Germany Neuropediatrics. 2022 Dec 27. doi: 10.1055/a-1959-9241.","abstract":"BACKGROUND: Focal cortical dysplasias (FCD) are a frequent cause of drug-resistant epilepsy in children but are often undetected on structural magnetic resonance imaging (MRI). We aimed to measure and validate the variation of resting state functional MRI (rs-fMRI) blood oxygenation level dependent (BOLD) metrics in surgically proven FCDs in children, to assess the potential yield for detecting and understanding these lesions. METHODS: We prospectively included pediatric patients with surgically proven FCD with inconclusive structural MRI and healthy controls, who underwent a ten-minute rs-fMRI acquired at 3T. Rs-fMRI data was pre-processed and maps of values of regional homogeneity (ReHo), degree centrality (DC), amplitude of low frequency fluctuations (ALFF) and fractional ALFF (fALFF) were calculated. The variations of BOLD metrics within the to-be-resected areas were analyzed visually, and quantitatively using lateralization indices. BOLD metrics variations were also analyzed in fluorodeoxyglucose-positron emission tomography (FDG-PET) hypometabolic areas. RESULTS: We included 7 patients (range: 3-15 years) and 6 aged-matched controls (range: 6-17 years). ReHo lateralization indices were positive in the to-be-resected areas in 4/7 patients, and in 6/7 patients in the additional PET hypometabolic areas. These indices were significantly higher compared to controls in 3/7 and 4/7 patients, respectively. Visual analysis revealed a good spatial correlation between high ReHo areas and MRI structural abnormalities (when present) or PET hypometabolic areas. No consistent variation was seen using DC, ALFF, or fALFF. CONCLUSION: Resting-state fMRI metrics, noticeably increase in ReHo, may have potential to help detect MRI-negative FCDs in combination with other morphological and functional techniques, used in clinical practice and epilepsy-surgery screening.","issn":"1439-1899 (Electronic) 0174-304X (Linking)","doi":"10.1055/a-1959-9241","url":"https://www.ncbi.nlm.nih.gov/pubmed/36223876","year":"2022","bibtex":"@article{RN322,\n author = {Dangouloff-Ros, V. and Jansen, J. F. A. and de Jong, J. and Postma, A. A. and Hoeberigs, C. and Fillon, L. and Boisgontier, J. and Roux, C. J. and Levy, R. and Varlet, P. and Blauwblomme, T. and Eisermann, M. and Losito, E. and Bourgeois, M. and Chiron, C. and Nabbout, R. and Boddaert, N. and Backes, W.},\n title = {Abnormal Spontaneous Blood Oxygenation Level Dependent Fluctuations in Children with Focal Cortical Dysplasias: Initial Findings in Surgically Confirmed Cases},\n journal = {Neuropediatrics},\n note = {Dangouloff-Ros, Volodia\nJansen, Jacobus F A\nde Jong, Joost\nPostma, Alida A\nHoeberigs, Christianne\nFillon, Ludovic\nBoisgontier, Jennifer\nRoux, Charles-Joris\nLevy, Raphael\nVarlet, Pascale\nBlauwblomme, Thomas\nEisermann, Monika\nLosito, Emma\nBourgeois, Marie\nChiron, Catherine\nNabbout, Rima\nBoddaert, Nathalie\nBackes, Walter\neng\nSociete Francaise de Radiologie/Alain Rahmouni Research Grant/\nGermany\nNeuropediatrics. 2022 Dec 27. doi: 10.1055/a-1959-9241.},\n abstract = {BACKGROUND: Focal cortical dysplasias (FCD) are a frequent cause of drug-resistant epilepsy in children but are often undetected on structural magnetic resonance imaging (MRI). We aimed to measure and validate the variation of resting state functional MRI (rs-fMRI) blood oxygenation level dependent (BOLD) metrics in surgically proven FCDs in children, to assess the potential yield for detecting and understanding these lesions. METHODS: We prospectively included pediatric patients with surgically proven FCD with inconclusive structural MRI and healthy controls, who underwent a ten-minute rs-fMRI acquired at 3T. Rs-fMRI data was pre-processed and maps of values of regional homogeneity (ReHo), degree centrality (DC), amplitude of low frequency fluctuations (ALFF) and fractional ALFF (fALFF) were calculated. The variations of BOLD metrics within the to-be-resected areas were analyzed visually, and quantitatively using lateralization indices. BOLD metrics variations were also analyzed in fluorodeoxyglucose-positron emission tomography (FDG-PET) hypometabolic areas. RESULTS: We included 7 patients (range: 3-15 years) and 6 aged-matched controls (range: 6-17 years). ReHo lateralization indices were positive in the to-be-resected areas in 4/7 patients, and in 6/7 patients in the additional PET hypometabolic areas. These indices were significantly higher compared to controls in 3/7 and 4/7 patients, respectively. Visual analysis revealed a good spatial correlation between high ReHo areas and MRI structural abnormalities (when present) or PET hypometabolic areas. No consistent variation was seen using DC, ALFF, or fALFF. CONCLUSION: Resting-state fMRI metrics, noticeably increase in ReHo, may have potential to help detect MRI-negative FCDs in combination with other morphological and functional techniques, used in clinical practice and epilepsy-surgery screening.},\n ISSN = {1439-1899 (Electronic)\n0174-304X (Linking)},\n DOI = {10.1055/a-1959-9241},\n url = {https://www.ncbi.nlm.nih.gov/pubmed/36223876},\n year = {2022},\n type = {Journal Article}\n}\n\n","author_short":["Dangouloff-Ros, V.","Jansen, J. F. A.","de Jong, J.","Postma, A. A.","Hoeberigs, C.","Fillon, L.","Boisgontier, J.","Roux, C. J.","Levy, R.","Varlet, P.","Blauwblomme, T.","Eisermann, M.","Losito, E.","Bourgeois, M.","Chiron, C.","Nabbout, R.","Boddaert, N.","Backes, W."],"key":"RN322","id":"RN322","bibbaseid":"dangouloffros-jansen-dejong-postma-hoeberigs-fillon-boisgontier-roux-etal-abnormalspontaneousbloodoxygenationleveldependentfluctuationsinchildrenwithfocalcorticaldysplasiasinitialfindingsinsurgicallyconfirmedcases-2022","role":"author","urls":{"Paper":"https://www.ncbi.nlm.nih.gov/pubmed/36223876"},"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","dataSources":["TCkfRWJAZvbLAZi29"],"keywords":[],"search_terms":["abnormal","spontaneous","blood","oxygenation","level","dependent","fluctuations","children","focal","cortical","dysplasias","initial","findings","surgically","confirmed","cases","dangouloff-ros","jansen","de jong","postma","hoeberigs","fillon","boisgontier","roux","levy","varlet","blauwblomme","eisermann","losito","bourgeois","chiron","nabbout","boddaert","backes"],"title":"Abnormal Spontaneous Blood Oxygenation Level Dependent Fluctuations in Children with Focal Cortical Dysplasias: Initial Findings in Surgically Confirmed Cases","year":2022}