A systematic review on the effect of HIV infection on the pharmacokinetics of first-line tuberculosis drugs. Daskapan, A., Idrus, L. R., Postma, M. J, Wilffert, B., Kosterink, J. G W, Stienstra, Y., Touw, D. J, Andersen, A. B, Bekker, A., Denti, P., Hemanth Kumar, A. K, Jeremiah, K., Kwara, A., McIlleron, H., Meintjes, G. A, van Oosterhout, J. J, Ramachandran, G., Rockwood, N., Wilkinson, R. J, van der Werf, T. S, & Alffenaar, J. C Clinical Pharmacokinetics, 58(6):747–766, Springer International Publishing, nov, 2019. ![A systematic review on the effect of HIV infection on the pharmacokinetics of first-line tuberculosis drugs [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Introduction Contrasting findings have been published regarding the effect of human immunodeficiency virus (HIV) on tuberculosis (TB) drug pharmacokinetics (PK). Objectives The aim of this systematic review was to investigate the effect of HIV infection on the PK of the first-line TB drugs (FLDs) rifampicin, isoniazid, pyrazinamide and ethambutol by assessing all published literature. Methods Searches were performed in MEDLINE (through PubMed) and EMBASE to find original studies evaluating the effect of HIV infection on the PK of FLDs. The included studies were assessed for bias and clinical relevance. PK data were extracted to provide insight into the difference of FLD PK between HIV-positive and HIV-negative TB patients. This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement and its protocol was registered at PROSPERO (registration number CRD42017067250). Results Overall, 27 studies were eligible for inclusion. The available studies provide a heterogeneous dataset from which consistent results could not be obtained. In both HIV-positive and HIV-negative TB groups, rifampicin (13 of 15) and ethambutol (4 of 8) peak concentration (Cmax) often did not achieve the minimum reference values. More than half of the studies (11 of 20) that included both HIV-positive and HIV-negative TB groups showed statistically significantly altered FLD area under the concentration–time curve and/or Cmax for at least one FLD. Conclusions HIV infection may be one of several factors that reduce FLD exposure. We could not make general recommendations with respect to the role of dosing. There is a need for consistent and homogeneous studies to be conducted.
@article{Daskapan2018,
abstract = {Introduction Contrasting findings have been published regarding the effect of human immunodeficiency virus (HIV) on tuberculosis (TB) drug pharmacokinetics (PK). Objectives The aim of this systematic review was to investigate the effect of HIV infection on the PK of the first-line TB drugs (FLDs) rifampicin, isoniazid, pyrazinamide and ethambutol by assessing all published literature. Methods Searches were performed in MEDLINE (through PubMed) and EMBASE to find original studies evaluating the effect of HIV infection on the PK of FLDs. The included studies were assessed for bias and clinical relevance. PK data were extracted to provide insight into the difference of FLD PK between HIV-positive and HIV-negative TB patients. This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement and its protocol was registered at PROSPERO (registration number CRD42017067250). Results Overall, 27 studies were eligible for inclusion. The available studies provide a heterogeneous dataset from which consistent results could not be obtained. In both HIV-positive and HIV-negative TB groups, rifampicin (13 of 15) and ethambutol (4 of 8) peak concentration (Cmax) often did not achieve the minimum reference values. More than half of the studies (11 of 20) that included both HIV-positive and HIV-negative TB groups showed statistically significantly altered FLD area under the concentration–time curve and/or Cmax for at least one FLD. Conclusions HIV infection may be one of several factors that reduce FLD exposure. We could not make general recommendations with respect to the role of dosing. There is a need for consistent and homogeneous studies to be conducted.},
author = {Daskapan, Alper and Idrus, Lusiana R. and Postma, Maarten J and Wilffert, Bob and Kosterink, Jos G W and Stienstra, Ymkje and Touw, Daniel J and Andersen, Aase B and Bekker, Adrie and Denti, Paolo and {Hemanth Kumar}, Agibothu K and Jeremiah, Kidola and Kwara, Awewura and McIlleron, Helen and Meintjes, Graeme A and van Oosterhout, Joep J and Ramachandran, Geetha and Rockwood, Neesha and Wilkinson, Robert J and van der Werf, Tjip S and Alffenaar, Jan-Willem C},
doi = {10.1007/s40262-018-0716-8},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Daskapan et al. - 2019 - A systematic review on the effect of HIV infection on the pharmacokinetics of first-line tuberculosis drugs.pdf:pdf},
journal = {Clinical Pharmacokinetics},
keywords = {OA,fund{\_}not{\_}ack,review},
mendeley-tags = {OA,fund{\_}not{\_}ack,review},
month = {nov},
number = {6},
pages = {747--766},
pmid = {30406475},
publisher = {Springer International Publishing},
title = {{A systematic review on the effect of HIV infection on the pharmacokinetics of first-line tuberculosis drugs}},
url = {http://link.springer.com/10.1007/s40262-018-0716-8},
volume = {58},
year = {2019}
}
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Objectives The aim of this systematic review was to investigate the effect of HIV infection on the PK of the first-line TB drugs (FLDs) rifampicin, isoniazid, pyrazinamide and ethambutol by assessing all published literature. Methods Searches were performed in MEDLINE (through PubMed) and EMBASE to find original studies evaluating the effect of HIV infection on the PK of FLDs. The included studies were assessed for bias and clinical relevance. PK data were extracted to provide insight into the difference of FLD PK between HIV-positive and HIV-negative TB patients. This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement and its protocol was registered at PROSPERO (registration number CRD42017067250). Results Overall, 27 studies were eligible for inclusion. The available studies provide a heterogeneous dataset from which consistent results could not be obtained. In both HIV-positive and HIV-negative TB groups, rifampicin (13 of 15) and ethambutol (4 of 8) peak concentration (Cmax) often did not achieve the minimum reference values. More than half of the studies (11 of 20) that included both HIV-positive and HIV-negative TB groups showed statistically significantly altered FLD area under the concentration–time curve and/or Cmax for at least one FLD. Conclusions HIV infection may be one of several factors that reduce FLD exposure. We could not make general recommendations with respect to the role of dosing. 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