@article{ WOS:000227162700011,
Author = {Davalos, RV and Mir, LM and Rubinsky, B},
Title = {Tissue ablation with irreversible electroporation},
Journal = {ANNALS OF BIOMEDICAL ENGINEERING},
Year = {2005},
Volume = {33},
Number = {2},
Pages = {223-231},
Month = {FEB},
Abstract = {This study introduces a new method for minimally invasive treatment of
   cancer - the ablation of undesirable tissue through the use of
   irreversible electroporation. Electroporation is the permeabilization of
   the cell membrane due to an applied electric field. As a function of the
   field amplitude and duration, the permeabilization can be reversible or
   irreversible. Over the last decade, reversible electroporation has been
   intensively pursued as a very promising technique for the treatment of
   cancer. It is used in combination with cytotoxic drugs, such as
   bleomycin, in a technique known as electrochemotherapy. However,
   irreversible electroporation was completely ignored in cancer therapy.
   We show through mathematical analysis that irreversible electroporation
   can ablate substantial volumes of tissue, comparable to those achieved
   with other ablation techniques, without causing any detrimental thermal
   effects and without the need of adjuvant drugs. This study suggests that
   irreversible electroporation may become an important and innovative tool
   in the armamentarium of surgeons treating cancer.},
Publisher = {SPRINGER},
Address = {233 SPRING ST, NEW YORK, NY 10013 USA},
Type = {Article},
Language = {English},
Affiliation = {Davalos, RV (Corresponding Author), Sandia Natl Labs, 7011 East Ave,MS 9036, Livermore, CA 94550 USA.
   Sandia Natl Labs, Livermore, CA 94550 USA.
   Inst Gustave Roussy, CNRS, UMR 8121, Villejuif, France.
   Univ Calif Berkeley, Dept Mech Engn, Biomed Engn Lab, Berkeley, CA 94720 USA.},
DOI = {10.1007/s10439-005-8981-8},
ISSN = {0090-6964},
EISSN = {1573-9686},
Keywords = {electropermeabilization; cancer therapy; bioheat equation},
Keywords-Plus = {ELECTRICAL-IMPEDANCE TOMOGRAPHY; GENE DELIVERY; ELECTROCHEMOTHERAPY;
   MEMBRANES; BREAKDOWN; FIELDS; TUMORS; CELLS; CRYOSURGERY; BLEOMYCIN},
Research-Areas = {Engineering},
Web-of-Science-Categories  = {Engineering, Biomedical},
Author-Email = {rvdaval@sandia.gov},
Affiliations = {United States Department of Energy (DOE); Sandia National Laboratories;
   Centre National de la Recherche Scientifique (CNRS); UNICANCER; Gustave
   Roussy; University of California System; University of California
   Berkeley},
ResearcherID-Numbers = {yang, xiao-jun/B-1927-2009
   MIR, Lluis M/AAJ-9110-2020
   Rubinsky, Boris/B-4439-2010
   Davalos, Rafael V/F-9012-2011
   },
ORCID-Numbers = {, Lluis/0000-0002-8671-9467},
Funding-Acknowledgement = {NCRR NIH HHS {[}R01-RR018961] Funding Source: Medline},
Number-of-Cited-References = {44},
Times-Cited = {932},
Usage-Count-Last-180-days = {4},
Usage-Count-Since-2013 = {137},
Journal-ISO = {Ann. Biomed. Eng.},
Doc-Delivery-Number = {899RO},
Web-of-Science-Index = {Science Citation Index Expanded (SCI-EXPANDED)},
Unique-ID = {WOS:000227162700011},
DA = {2024-03-03},
}

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Electroporation is the permeabilization of the cell membrane due to an applied electric field. As a function of the field amplitude and duration, the permeabilization can be reversible or irreversible. Over the last decade, reversible electroporation has been intensively pursued as a very promising technique for the treatment of cancer. It is used in combination with cytotoxic drugs, such as bleomycin, in a technique known as electrochemotherapy. However, irreversible electroporation was completely ignored in cancer therapy. We show through mathematical analysis that irreversible electroporation can ablate substantial volumes of tissue, comparable to those achieved with other ablation techniques, without causing any detrimental thermal effects and without the need of adjuvant drugs. 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