Electrical impedance tomography of cell viability in tissue with application to cryosurgery. Davalos, R. & Rubinsky, B. J Biomech Eng, 126(2):305-9, 2004. Davalos, Rafael Rubinsky, Boris 5RO1 RR14591/RR/NCRR NIH HHS/United States Comparative Study Evaluation Study Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Validation Study United States 2004/06/08 J Biomech Eng. 2004 Apr;126(2):305-9. doi: 10.1115/1.1695577.
doi  abstract   bibtex   
Tissue damage that is associated with the loss of cell membrane integrity should alter the bulk electrical properties of the tissue. This study shows that electrical impedance tomography (EIT) should be able to detect and image necrotic tissue inside the body due to the permeabilization of the membrane to ions. Cryosurgery, a minimally invasive surgical procedure that uses freezing to destroy undesirable tissue, was used to investigate the hypothesis. Experimental results with liver tissue demonstrate that cell damage during freezing results in substantial changes in tissue electrical properties. Two-dimensional EIT simulations of liver cryosurgery, which employ the experimental data, demonstrate the feasibility of this application.
@article{RN247,
   author = {Davalos, R. and Rubinsky, B.},
   title = {Electrical impedance tomography of cell viability in tissue with application to cryosurgery},
   journal = {J Biomech Eng},
   volume = {126},
   number = {2},
   pages = {305-9},
   note = {Davalos, Rafael
Rubinsky, Boris
5RO1 RR14591/RR/NCRR NIH HHS/United States
Comparative Study
Evaluation Study
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Validation Study
United States
2004/06/08
J Biomech Eng. 2004 Apr;126(2):305-9. doi: 10.1115/1.1695577.},
   abstract = {Tissue damage that is associated with the loss of cell membrane integrity should alter the bulk electrical properties of the tissue. This study shows that electrical impedance tomography (EIT) should be able to detect and image necrotic tissue inside the body due to the permeabilization of the membrane to ions. Cryosurgery, a minimally invasive surgical procedure that uses freezing to destroy undesirable tissue, was used to investigate the hypothesis. Experimental results with liver tissue demonstrate that cell damage during freezing results in substantial changes in tissue electrical properties. Two-dimensional EIT simulations of liver cryosurgery, which employ the experimental data, demonstrate the feasibility of this application.},
   keywords = {Animals
Cell Count/instrumentation/methods
Cell Survival
Cryosurgery/*adverse effects
Culture Techniques/instrumentation/methods
*Electric Impedance
Feasibility Studies
*Freezing
Liver/*pathology/physiopathology/*surgery
Liver Diseases/*etiology/*pathology/physiopathology
Rats
Rats, Sprague-Dawley
Tomography/instrumentation/*methods},
   ISSN = {0148-0731 (Print)
0148-0731},
   DOI = {10.1115/1.1695577},
   year = {2004},
   type = {Journal Article}
}

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