Slow calcium waves and redox changes precede mitochondrial permeability transition pore opening in the intact heart during hypoxia and reoxygenation. Davidson, S., M., Yellon, D., M., Murphy, M., P., & Duchen, M., R. Cardiovascular research, 93(3):445-53, 3, 2012.
Slow calcium waves and redox changes precede mitochondrial permeability transition pore opening in the intact heart during hypoxia and reoxygenation. [link]Website  abstract   bibtex   
Opening of the mitochondrial permeability transition pore (mPTP) is an important step on the pathway towards cardiomyocyte death, defining the extent of injury following cardiac ischaemia and reperfusion. In isolated mitochondria, mPTP opening is triggered by calcium overload facilitated by oxidative stress. In isolated cells, however, it has been suggested that mPTP opening occurs before calcium overload and is stimulated by oxidative stress. Our objective was to establish the events that cause mPTP opening in the intact heart.
@article{
 title = {Slow calcium waves and redox changes precede mitochondrial permeability transition pore opening in the intact heart during hypoxia and reoxygenation.},
 type = {article},
 year = {2012},
 identifiers = {[object Object]},
 keywords = {Animals,Anoxia,Anoxia: metabolism,Anoxia: pathology,Anoxia: physiopathology,Calcium Signaling,Calcium Signaling: physiology,Cell Death,Cell Death: physiology,Mice,Mitochondrial Membrane Transport Proteins,Mitochondrial Membrane Transport Proteins: metabol,Mitochondrial Membranes,Mitochondrial Membranes: metabolism,Myocardial Reperfusion Injury,Myocardial Reperfusion Injury: metabolism,Myocardial Reperfusion Injury: pathology,Myocardial Reperfusion Injury: physiopathology,Myocardium,Myocardium: metabolism,Myocardium: pathology,Myocytes, Cardiac,Myocytes, Cardiac: pathology,Myocytes, Cardiac: physiology,Oxidation-Reduction,Perfusion,Rats},
 pages = {445-53},
 volume = {93},
 websites = {http://cardiovascres.oxfordjournals.org/content/93/3/445.short},
 month = {3},
 day = {1},
 id = {7adbe8e0-000a-345f-b896-c9c6071b3af1},
 created = {2013-02-17T20:04:47.000Z},
 accessed = {2013-02-17},
 file_attached = {false},
 profile_id = {409abeb6-746c-3cb1-be13-1f6c69a35474},
 last_modified = {2017-03-15T18:44:14.327Z},
 tags = {langendorff,two-photon},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 notes = {measure waves in intact heart using two photon microscope},
 private_publication = {false},
 abstract = {Opening of the mitochondrial permeability transition pore (mPTP) is an important step on the pathway towards cardiomyocyte death, defining the extent of injury following cardiac ischaemia and reperfusion. In isolated mitochondria, mPTP opening is triggered by calcium overload facilitated by oxidative stress. In isolated cells, however, it has been suggested that mPTP opening occurs before calcium overload and is stimulated by oxidative stress. Our objective was to establish the events that cause mPTP opening in the intact heart.},
 bibtype = {article},
 author = {Davidson, Sean M and Yellon, Derek M and Murphy, Michael P and Duchen, Michael R},
 journal = {Cardiovascular research},
 number = {3}
}

Downloads: 0