@article{Davies2024,
abstract = {Antibody features vary with tuberculosis (TB) disease state. Whether clinical variables, such as age or sex, influence associations between Mycobacterium tuberculosis-specific antibody responses and disease state is not well explored. Here we profiled Mycobacterium tuberculosis-specific antibody responses in 140 TB-exposed South African individuals from the Adolescent Cohort Study. We identified distinct response features in individuals progressing to active TB from non-progressing, matched controls. A multivariate antibody score differentially associated with progression (SeroScore) identified progressors up to 2 years before TB diagnosis, earlier than that achieved with the RISK6 transcriptional signature of progression. We validated these antibody response features in the Grand Challenges 6–74 cohort. Both the SeroScore and RISK6 correlated better with risk of TB progression in adolescents compared with adults, and in males compared with females. This suggests that age and sex are important, underappreciated modifiers of antibody responses associated with TB progression. Analysis of Mycobacterium tuberculosis-specific antibody responses in previously exposed South African cohorts reveals that profile features associated with progression to active tuberculosis are affected by age and sex.},
author = {Davies, Leela R L and Wang, Chuangqi and Steigler, Pia and Bowman, Kathryn A and Fischinger, Stephanie and Hatherill, Mark and Fisher, Michelle and Mbandi, Stanley Kimbung and Rodo, Miguel and Ottenhoff, Tom H M and Dockrell, Hazel M and Sutherland, Jayne S and Mayanja-Kizza, Harriet and Boom, W Henry and Walzl, Gerhard and Kaufmann, Stefan H E and Nemes, Elisa and Scriba, Thomas J and Lauffenburger, Douglas and Alter, Galit and Fortune, Sarah M},
doi = {10.1038/s41564-024-01678-x},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Davies et al. - 2024 - Age and sex influence antibody profiles associated with tuberculosis progression.pdf:pdf},
issn = {2058-5276},
journal = {Nature Microbiology},
keywords = {Antibodies,OA,Tuberculosis,fund{\_}not{\_}ack,original},
mendeley-tags = {OA,fund{\_}not{\_}ack,original},
month = {apr},
pages = {https://doi.org/10.1038/s41564--024--01678--x},
pmid = {38658786},
publisher = {Nature Publishing Group},
title = {{Age and sex influence antibody profiles associated with tuberculosis progression}},
url = {https://www.nature.com/articles/s41564-024-01678-x},
year = {2024}
}

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We identified distinct response features in individuals progressing to active TB from non-progressing, matched controls. A multivariate antibody score differentially associated with progression (SeroScore) identified progressors up to 2 years before TB diagnosis, earlier than that achieved with the RISK6 transcriptional signature of progression. We validated these antibody response features in the Grand Challenges 6–74 cohort. Both the SeroScore and RISK6 correlated better with risk of TB progression in adolescents compared with adults, and in males compared with females. This suggests that age and sex are important, underappreciated modifiers of antibody responses associated with TB progression. 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