The pathogenesis of tuberculous meningitis. Davis, A. G, Rohlwink, U. K, Proust, A., Figaji, A. A, & Wilkinson, R. J Journal of Leukocyte Biology, 105(2):267–280, John Wiley & Sons, Ltd, jan, 2019. ![The pathogenesis of tuberculous meningitis [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Tuberculosis (TB) remains a leading cause of death globally. Dissemination of TB to the brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM), which represents a medical emergency associated with high rates of mortality and disability. Via various mechanisms the Mycobacterium tuberculosis (M.tb) bacillus disseminates from the primary site of infection and overcomes protective barriers to enter the CNS. There it induces an inflammatory response involving both the peripheral and resident immune cells, which initiates a cascade of pathologic mechanisms that may either contain the disease or result in significant brain injury. Here we review the steps from primary infection to cerebral disease, factors that contribute to the virulence of the organism and the vulnerability of the host and discuss the immune response and the clinical manifestations arising. Priorities for future research directions are suggested.
@article{Davis2019,
abstract = {Tuberculosis (TB) remains a leading cause of death globally. Dissemination of TB to the brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM), which represents a medical emergency associated with high rates of mortality and disability. Via various mechanisms the Mycobacterium tuberculosis (M.tb) bacillus disseminates from the primary site of infection and overcomes protective barriers to enter the CNS. There it induces an inflammatory response involving both the peripheral and resident immune cells, which initiates a cascade of pathologic mechanisms that may either contain the disease or result in significant brain injury. Here we review the steps from primary infection to cerebral disease, factors that contribute to the virulence of the organism and the vulnerability of the host and discuss the immune response and the clinical manifestations arising. Priorities for future research directions are suggested.},
author = {Davis, Angharad G and Rohlwink, Ursula K and Proust, Aliz{\'{e}} and Figaji, Anthony A and Wilkinson, Robert J},
doi = {10.1002/JLB.MR0318-102R},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Davis et al. - 2019 - The pathogenesis of tuberculous meningitis.pdf:pdf},
journal = {Journal of Leukocyte Biology},
keywords = {fund{\_}ack,review},
mendeley-tags = {fund{\_}ack,review},
month = {jan},
number = {2},
pages = {267--280},
pmid = {30645042},
publisher = {John Wiley {\&} Sons, Ltd},
title = {{The pathogenesis of tuberculous meningitis}},
url = {http://doi.wiley.com/10.1002/JLB.MR0318-102R https://jlb.onlinelibrary.wiley.com/doi/full/10.1002/JLB.MR0318-102R},
volume = {105},
year = {2019}
}
Downloads: 0
{"_id":"Da4oFDNzSd2eE8iGy","bibbaseid":"davis-rohlwink-proust-figaji-wilkinson-thepathogenesisoftuberculousmeningitis-2019","author_short":["Davis, A. G","Rohlwink, U. K","Proust, A.","Figaji, A. A","Wilkinson, R. J"],"bibdata":{"bibtype":"article","type":"article","abstract":"Tuberculosis (TB) remains a leading cause of death globally. Dissemination of TB to the brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM), which represents a medical emergency associated with high rates of mortality and disability. Via various mechanisms the Mycobacterium tuberculosis (M.tb) bacillus disseminates from the primary site of infection and overcomes protective barriers to enter the CNS. There it induces an inflammatory response involving both the peripheral and resident immune cells, which initiates a cascade of pathologic mechanisms that may either contain the disease or result in significant brain injury. Here we review the steps from primary infection to cerebral disease, factors that contribute to the virulence of the organism and the vulnerability of the host and discuss the immune response and the clinical manifestations arising. Priorities for future research directions are suggested.","author":[{"propositions":[],"lastnames":["Davis"],"firstnames":["Angharad","G"],"suffixes":[]},{"propositions":[],"lastnames":["Rohlwink"],"firstnames":["Ursula","K"],"suffixes":[]},{"propositions":[],"lastnames":["Proust"],"firstnames":["Alizé"],"suffixes":[]},{"propositions":[],"lastnames":["Figaji"],"firstnames":["Anthony","A"],"suffixes":[]},{"propositions":[],"lastnames":["Wilkinson"],"firstnames":["Robert","J"],"suffixes":[]}],"doi":"10.1002/JLB.MR0318-102R","file":":C$\\$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Davis et al. - 2019 - The pathogenesis of tuberculous meningitis.pdf:pdf","journal":"Journal of Leukocyte Biology","keywords":"fund_ack,review","mendeley-tags":"fund_ack,review","month":"jan","number":"2","pages":"267–280","pmid":"30645042","publisher":"John Wiley & Sons, Ltd","title":"The pathogenesis of tuberculous meningitis","url":"http://doi.wiley.com/10.1002/JLB.MR0318-102R https://jlb.onlinelibrary.wiley.com/doi/full/10.1002/JLB.MR0318-102R","volume":"105","year":"2019","bibtex":"@article{Davis2019,\r\nabstract = {Tuberculosis (TB) remains a leading cause of death globally. Dissemination of TB to the brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM), which represents a medical emergency associated with high rates of mortality and disability. Via various mechanisms the Mycobacterium tuberculosis (M.tb) bacillus disseminates from the primary site of infection and overcomes protective barriers to enter the CNS. There it induces an inflammatory response involving both the peripheral and resident immune cells, which initiates a cascade of pathologic mechanisms that may either contain the disease or result in significant brain injury. Here we review the steps from primary infection to cerebral disease, factors that contribute to the virulence of the organism and the vulnerability of the host and discuss the immune response and the clinical manifestations arising. Priorities for future research directions are suggested.},\r\nauthor = {Davis, Angharad G and Rohlwink, Ursula K and Proust, Aliz{\\'{e}} and Figaji, Anthony A and Wilkinson, Robert J},\r\ndoi = {10.1002/JLB.MR0318-102R},\r\nfile = {:C$\\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Davis et al. - 2019 - The pathogenesis of tuberculous meningitis.pdf:pdf},\r\njournal = {Journal of Leukocyte Biology},\r\nkeywords = {fund{\\_}ack,review},\r\nmendeley-tags = {fund{\\_}ack,review},\r\nmonth = {jan},\r\nnumber = {2},\r\npages = {267--280},\r\npmid = {30645042},\r\npublisher = {John Wiley {\\&} Sons, Ltd},\r\ntitle = {{The pathogenesis of tuberculous meningitis}},\r\nurl = {http://doi.wiley.com/10.1002/JLB.MR0318-102R https://jlb.onlinelibrary.wiley.com/doi/full/10.1002/JLB.MR0318-102R},\r\nvolume = {105},\r\nyear = {2019}\r\n}\r\n","author_short":["Davis, A. G","Rohlwink, U. K","Proust, A.","Figaji, A. A","Wilkinson, R. J"],"key":"Davis2019","id":"Davis2019","bibbaseid":"davis-rohlwink-proust-figaji-wilkinson-thepathogenesisoftuberculousmeningitis-2019","role":"author","urls":{"Paper":"http://doi.wiley.com/10.1002/JLB.MR0318-102R https://jlb.onlinelibrary.wiley.com/doi/full/10.1002/JLB.MR0318-102R"},"keyword":["fund_ack","review"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://drive.google.com/uc?export=download&id=1-JLqZ7RwZ3VC2d6ErLGHAtOeMRS_7GCz","dataSources":["Krmt6gt9ktB2s6ARh"],"keywords":["fund_ack","review"],"search_terms":["pathogenesis","tuberculous","meningitis","davis","rohlwink","proust","figaji","wilkinson"],"title":"The pathogenesis of tuberculous meningitis","year":2019}