@article{DeBoer2025,
abstract = {INTRODUCTION: We investigated international differences in facial emotion  recognition (FER) across stages of frontotemporal dementia (FTD). Previous studies may have missed early decline by combining data and masking variations in FER across countries. METHODS: An FER test was administered to 159 individuals with behavioral variant FTD, 521 presymptomatic pathogenic variant carriers, and 583 controls from 16 countries of residence. Linear mixed models assessed age, sex, education, and country effects on FER. Voxel-based morphometry examined neural correlates across countries. REULTS: Country accounted for 18%-18.3% of FER variance in presymptomatic carriers and controls and 9.9% in individuals with behavioral variant of FTD (bvFTD). Cross-country differences interacted with the effects of sex, age, and education. Neural correlates involving the frontal lobe and basal ganglia were identified in individuals with bvFTD, but no cross-country differences were found. DISCUSSION: These results underscore the need for culturally sensitive FER tools in research and clinical practice, especially as global multinational clinical trials emerge. HIGHLIGHTS: Performance on a test for facial emotion recognition (FER) varies between countries. The percentage of variance is lower in the behavioral variant of frontotemporal dementia (bvFTD) compared to presymptomatic pathogenic variant carriers and healthy controls. Cross-country differences interacted with the effects of sex, age, and education. There were no differences in brain correlates of FER across countries.},
author = {de Boer, Liset and Jiskoot, Lize C and Seelaar, Harro and van Swieten, John C and Ibanez, Agustin and Maito, Marcelo and Fittipaldi, Sol and {De Houwer}, Julie F H and Swartenbroekx, Tine and Boesjes, Pam A and Convery, Rhian S and Ferry-Bolder, Eve and Foster, Phoebe and Bouzigues, Arabella and Chisman-Russell, Lucy and van den Berg, Esther and Papma, Janne and Franzen, Sanne and Bourdage, Renelle and Rowe, James B and Borroni, Barbara and Galimberti, Daniela and Tiraboschi, Pietro and Masellis, Mario and Finger, Elizabeth and Laforce, Robert and Graff, Caroline and Gerhard, Alexander and Sanchez-Valle, Raquel and Mendon{\c{c}}a, Alexandre and Moreno, Fermin and Synofzik, Matthis and Vandenberghe, Rik and Ducharme, Simon and {Le Ber}, Isabelle and Levin, Johannes and Lebouvier, Thibaud and Nacmias, Benedetta and Otto, Markus and Butler, Christopher R and Santana, Isabel and Bertoux, Maxime and Tartaglia, M Carmela and Rohrer, Jonathan D and Poos, Jackie M},
doi = {10.1002/alz.70741},
institution = {GENFI Consortium},
issn = {1552-5279 (Electronic)},
journal = {Alzheimer's & dementia : the journal of the Alzheimer's Association},
keywords = {Aged,Cross-Cultural Comparison,Emotions,Facial Expression,Facial Recognition,Female,Frontotemporal Dementia,Humans,Magnetic Resonance Imaging,Male,Middle Aged,Neuropsychological Tests,diagnostic imaging,genetics,physiology,physiopathology,psychology},
language = {eng},
month = {oct},
number = {10},
pages = {e70741},
pmid = {41085124},
title = {{Cross-country variance in facial emotion recognition in presymptomatic and  symptomatic behavioral variant frontotemporal dementia: Insights from the GENFI and ReDLat consortia.}},
volume = {21},
year = {2025}
}

{"_id":"7oPSMZkJg4Qeji42P","bibbaseid":"deboer-jiskoot-seelaar-vanswieten-ibanez-maito-fittipaldi-dehouwer-etal-crosscountryvarianceinfacialemotionrecognitioninpresymptomaticandsymptomaticbehavioralvariantfrontotemporaldementiainsightsfromthegenfiandredlatconsortia-2025","author_short":["de Boer, L.","Jiskoot, L. C","Seelaar, H.","van Swieten, J. C","Ibanez, A.","Maito, M.","Fittipaldi, S.","De Houwer, J. F H","Swartenbroekx, T.","Boesjes, P. A","Convery, R. S","Ferry-Bolder, E.","Foster, P.","Bouzigues, A.","Chisman-Russell, L.","van den Berg, E.","Papma, J.","Franzen, S.","Bourdage, R.","Rowe, J. B","Borroni, B.","Galimberti, D.","Tiraboschi, P.","Masellis, M.","Finger, E.","Laforce, R.","Graff, C.","Gerhard, A.","Sanchez-Valle, R.","Mendonça, A.","Moreno, F.","Synofzik, M.","Vandenberghe, R.","Ducharme, S.","Le Ber, I.","Levin, J.","Lebouvier, T.","Nacmias, B.","Otto, M.","Butler, C. R","Santana, I.","Bertoux, M.","Tartaglia, M C.","Rohrer, J. D","Poos, J. M"],"bibdata":{"bibtype":"article","type":"article","abstract":"INTRODUCTION: We investigated international differences in facial emotion recognition (FER) across stages of frontotemporal dementia (FTD). Previous studies may have missed early decline by combining data and masking variations in FER across countries. METHODS: An FER test was administered to 159 individuals with behavioral variant FTD, 521 presymptomatic pathogenic variant carriers, and 583 controls from 16 countries of residence. Linear mixed models assessed age, sex, education, and country effects on FER. Voxel-based morphometry examined neural correlates across countries. REULTS: Country accounted for 18%-18.3% of FER variance in presymptomatic carriers and controls and 9.9% in individuals with behavioral variant of FTD (bvFTD). Cross-country differences interacted with the effects of sex, age, and education. Neural correlates involving the frontal lobe and basal ganglia were identified in individuals with bvFTD, but no cross-country differences were found. DISCUSSION: These results underscore the need for culturally sensitive FER tools in research and clinical practice, especially as global multinational clinical trials emerge. HIGHLIGHTS: Performance on a test for facial emotion recognition (FER) varies between countries. The percentage of variance is lower in the behavioral variant of frontotemporal dementia (bvFTD) compared to presymptomatic pathogenic variant carriers and healthy controls. Cross-country differences interacted with the effects of sex, age, and education. There were no differences in brain correlates of FER across countries.","author":[{"propositions":["de"],"lastnames":["Boer"],"firstnames":["Liset"],"suffixes":[]},{"propositions":[],"lastnames":["Jiskoot"],"firstnames":["Lize","C"],"suffixes":[]},{"propositions":[],"lastnames":["Seelaar"],"firstnames":["Harro"],"suffixes":[]},{"propositions":["van"],"lastnames":["Swieten"],"firstnames":["John","C"],"suffixes":[]},{"propositions":[],"lastnames":["Ibanez"],"firstnames":["Agustin"],"suffixes":[]},{"propositions":[],"lastnames":["Maito"],"firstnames":["Marcelo"],"suffixes":[]},{"propositions":[],"lastnames":["Fittipaldi"],"firstnames":["Sol"],"suffixes":[]},{"propositions":[],"lastnames":["De Houwer"],"firstnames":["Julie","F","H"],"suffixes":[]},{"propositions":[],"lastnames":["Swartenbroekx"],"firstnames":["Tine"],"suffixes":[]},{"propositions":[],"lastnames":["Boesjes"],"firstnames":["Pam","A"],"suffixes":[]},{"propositions":[],"lastnames":["Convery"],"firstnames":["Rhian","S"],"suffixes":[]},{"propositions":[],"lastnames":["Ferry-Bolder"],"firstnames":["Eve"],"suffixes":[]},{"propositions":[],"lastnames":["Foster"],"firstnames":["Phoebe"],"suffixes":[]},{"propositions":[],"lastnames":["Bouzigues"],"firstnames":["Arabella"],"suffixes":[]},{"propositions":[],"lastnames":["Chisman-Russell"],"firstnames":["Lucy"],"suffixes":[]},{"propositions":["van","den"],"lastnames":["Berg"],"firstnames":["Esther"],"suffixes":[]},{"propositions":[],"lastnames":["Papma"],"firstnames":["Janne"],"suffixes":[]},{"propositions":[],"lastnames":["Franzen"],"firstnames":["Sanne"],"suffixes":[]},{"propositions":[],"lastnames":["Bourdage"],"firstnames":["Renelle"],"suffixes":[]},{"propositions":[],"lastnames":["Rowe"],"firstnames":["James","B"],"suffixes":[]},{"propositions":[],"lastnames":["Borroni"],"firstnames":["Barbara"],"suffixes":[]},{"propositions":[],"lastnames":["Galimberti"],"firstnames":["Daniela"],"suffixes":[]},{"propositions":[],"lastnames":["Tiraboschi"],"firstnames":["Pietro"],"suffixes":[]},{"propositions":[],"lastnames":["Masellis"],"firstnames":["Mario"],"suffixes":[]},{"propositions":[],"lastnames":["Finger"],"firstnames":["Elizabeth"],"suffixes":[]},{"propositions":[],"lastnames":["Laforce"],"firstnames":["Robert"],"suffixes":[]},{"propositions":[],"lastnames":["Graff"],"firstnames":["Caroline"],"suffixes":[]},{"propositions":[],"lastnames":["Gerhard"],"firstnames":["Alexander"],"suffixes":[]},{"propositions":[],"lastnames":["Sanchez-Valle"],"firstnames":["Raquel"],"suffixes":[]},{"propositions":[],"lastnames":["Mendonça"],"firstnames":["Alexandre"],"suffixes":[]},{"propositions":[],"lastnames":["Moreno"],"firstnames":["Fermin"],"suffixes":[]},{"propositions":[],"lastnames":["Synofzik"],"firstnames":["Matthis"],"suffixes":[]},{"propositions":[],"lastnames":["Vandenberghe"],"firstnames":["Rik"],"suffixes":[]},{"propositions":[],"lastnames":["Ducharme"],"firstnames":["Simon"],"suffixes":[]},{"propositions":[],"lastnames":["Le Ber"],"firstnames":["Isabelle"],"suffixes":[]},{"propositions":[],"lastnames":["Levin"],"firstnames":["Johannes"],"suffixes":[]},{"propositions":[],"lastnames":["Lebouvier"],"firstnames":["Thibaud"],"suffixes":[]},{"propositions":[],"lastnames":["Nacmias"],"firstnames":["Benedetta"],"suffixes":[]},{"propositions":[],"lastnames":["Otto"],"firstnames":["Markus"],"suffixes":[]},{"propositions":[],"lastnames":["Butler"],"firstnames":["Christopher","R"],"suffixes":[]},{"propositions":[],"lastnames":["Santana"],"firstnames":["Isabel"],"suffixes":[]},{"propositions":[],"lastnames":["Bertoux"],"firstnames":["Maxime"],"suffixes":[]},{"propositions":[],"lastnames":["Tartaglia"],"firstnames":["M","Carmela"],"suffixes":[]},{"propositions":[],"lastnames":["Rohrer"],"firstnames":["Jonathan","D"],"suffixes":[]},{"propositions":[],"lastnames":["Poos"],"firstnames":["Jackie","M"],"suffixes":[]}],"doi":"10.1002/alz.70741","institution":"GENFI Consortium","issn":"1552-5279 (Electronic)","journal":"Alzheimer's & dementia : the journal of the Alzheimer's Association","keywords":"Aged,Cross-Cultural Comparison,Emotions,Facial Expression,Facial Recognition,Female,Frontotemporal Dementia,Humans,Magnetic Resonance Imaging,Male,Middle Aged,Neuropsychological Tests,diagnostic imaging,genetics,physiology,physiopathology,psychology","language":"eng","month":"oct","number":"10","pages":"e70741","pmid":"41085124","title":"Cross-country variance in facial emotion recognition in presymptomatic and symptomatic behavioral variant frontotemporal dementia: Insights from the GENFI and ReDLat consortia.","volume":"21","year":"2025","bibtex":"@article{DeBoer2025,\nabstract = {INTRODUCTION: We investigated international differences in facial emotion recognition (FER) across stages of frontotemporal dementia (FTD). Previous studies may have missed early decline by combining data and masking variations in FER across countries. METHODS: An FER test was administered to 159 individuals with behavioral variant FTD, 521 presymptomatic pathogenic variant carriers, and 583 controls from 16 countries of residence. Linear mixed models assessed age, sex, education, and country effects on FER. Voxel-based morphometry examined neural correlates across countries. REULTS: Country accounted for 18%-18.3% of FER variance in presymptomatic carriers and controls and 9.9% in individuals with behavioral variant of FTD (bvFTD). Cross-country differences interacted with the effects of sex, age, and education. Neural correlates involving the frontal lobe and basal ganglia were identified in individuals with bvFTD, but no cross-country differences were found. DISCUSSION: These results underscore the need for culturally sensitive FER tools in research and clinical practice, especially as global multinational clinical trials emerge. HIGHLIGHTS: Performance on a test for facial emotion recognition (FER) varies between countries. The percentage of variance is lower in the behavioral variant of frontotemporal dementia (bvFTD) compared to presymptomatic pathogenic variant carriers and healthy controls. Cross-country differences interacted with the effects of sex, age, and education. There were no differences in brain correlates of FER across countries.},\nauthor = {de Boer, Liset and Jiskoot, Lize C and Seelaar, Harro and van Swieten, John C and Ibanez, Agustin and Maito, Marcelo and Fittipaldi, Sol and {De Houwer}, Julie F H and Swartenbroekx, Tine and Boesjes, Pam A and Convery, Rhian S and Ferry-Bolder, Eve and Foster, Phoebe and Bouzigues, Arabella and Chisman-Russell, Lucy and van den Berg, Esther and Papma, Janne and Franzen, Sanne and Bourdage, Renelle and Rowe, James B and Borroni, Barbara and Galimberti, Daniela and Tiraboschi, Pietro and Masellis, Mario and Finger, Elizabeth and Laforce, Robert and Graff, Caroline and Gerhard, Alexander and Sanchez-Valle, Raquel and Mendon{\\c{c}}a, Alexandre and Moreno, Fermin and Synofzik, Matthis and Vandenberghe, Rik and Ducharme, Simon and {Le Ber}, Isabelle and Levin, Johannes and Lebouvier, Thibaud and Nacmias, Benedetta and Otto, Markus and Butler, Christopher R and Santana, Isabel and Bertoux, Maxime and Tartaglia, M Carmela and Rohrer, Jonathan D and Poos, Jackie M},\ndoi = {10.1002/alz.70741},\ninstitution = {GENFI Consortium},\nissn = {1552-5279 (Electronic)},\njournal = {Alzheimer's & dementia : the journal of the Alzheimer's Association},\nkeywords = {Aged,Cross-Cultural Comparison,Emotions,Facial Expression,Facial Recognition,Female,Frontotemporal Dementia,Humans,Magnetic Resonance Imaging,Male,Middle Aged,Neuropsychological Tests,diagnostic imaging,genetics,physiology,physiopathology,psychology},\nlanguage = {eng},\nmonth = {oct},\nnumber = {10},\npages = {e70741},\npmid = {41085124},\ntitle = {{Cross-country variance in facial emotion recognition in presymptomatic and symptomatic behavioral variant frontotemporal dementia: Insights from the GENFI and ReDLat consortia.}},\nvolume = {21},\nyear = {2025}\n}\n","author_short":["de Boer, L.","Jiskoot, L. 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