Decreased T1 contrast between gray matter and normal-appearing white matter in CADASIL. De Guio, F., Reyes, S., Duering, M., Pirpamer, L., Chabriat, H., & Jouvent, E. AJNR Am J Neuroradiol, 35(1):72–6, January, 2014. doi abstract bibtex BACKGROUND AND PURPOSE: CADASIL is the most frequent hereditary small-vessel disease of the brain. The clinical impact of various MR imaging markers has been repeatedly studied in this disorder, but alterations of contrast between gray matter and normal-appearing white matter remain unknown. The aim of this study was to evaluate the contrast alterations between gray matter and normal-appearing white matter on T1-weighted images in patients with CADASIL compared with healthy subjects. MATERIALS AND METHODS: Contrast between gray matter and normal-appearing white matter was assessed by using histogram analyses of 3D T1 high-resolution MR imaging in 23 patients with CADASIL at the initial stage of the disease (Mini-Mental State Examination score \textgreater 24 and modified Rankin scale score \textless/= 1; mean age, 53.5 +/- 11.1 years) and 30 age- and sex-matched controls. RESULTS: T1 contrast between gray matter and normal-appearing white matter was significantly reduced in patients compared with age- and sex-matched controls (patients: 1.35 +/- 0.08 versus controls: 1.43 +/- 0.04, P \textless 10(-5)). This reduction was mainly driven by a signal decrease in normal-appearing white matter. Contrast loss was strongly related to the volume of white matter hyperintensities. CONCLUSIONS: Conventional 3D T1 imaging shows significant loss of contrast between gray matter and normal-appearing white matter in CADASIL. This probably reflects tissue changes in normal-appearing white matter outside signal abnormalities on T2 or FLAIR sequences. These contrast alterations should be taken into account for image interpretation and postprocessing.
@article{de_guio_decreased_2014,
title = {Decreased {T1} contrast between gray matter and normal-appearing white matter in {CADASIL}},
volume = {35},
issn = {1936-959X (Electronic) 0195-6108 (Linking)},
doi = {10.3174/ajnr.A3639},
abstract = {BACKGROUND AND PURPOSE: CADASIL is the most frequent hereditary small-vessel disease of the brain. The clinical impact of various MR imaging markers has been repeatedly studied in this disorder, but alterations of contrast between gray matter and normal-appearing white matter remain unknown. The aim of this study was to evaluate the contrast alterations between gray matter and normal-appearing white matter on T1-weighted images in patients with CADASIL compared with healthy subjects. MATERIALS AND METHODS: Contrast between gray matter and normal-appearing white matter was assessed by using histogram analyses of 3D T1 high-resolution MR imaging in 23 patients with CADASIL at the initial stage of the disease (Mini-Mental State Examination score {\textgreater} 24 and modified Rankin scale score {\textless}/= 1; mean age, 53.5 +/- 11.1 years) and 30 age- and sex-matched controls. RESULTS: T1 contrast between gray matter and normal-appearing white matter was significantly reduced in patients compared with age- and sex-matched controls (patients: 1.35 +/- 0.08 versus controls: 1.43 +/- 0.04, P {\textless} 10(-5)). This reduction was mainly driven by a signal decrease in normal-appearing white matter. Contrast loss was strongly related to the volume of white matter hyperintensities. CONCLUSIONS: Conventional 3D T1 imaging shows significant loss of contrast between gray matter and normal-appearing white matter in CADASIL. This probably reflects tissue changes in normal-appearing white matter outside signal abnormalities on T2 or FLAIR sequences. These contrast alterations should be taken into account for image interpretation and postprocessing.},
number = {1},
journal = {AJNR Am J Neuroradiol},
author = {De Guio, F. and Reyes, S. and Duering, M. and Pirpamer, L. and Chabriat, H. and Jouvent, E.},
month = jan,
year = {2014},
pmid = {23868154},
pmcid = {PMC7966464},
keywords = {Adult, Aged, Female, Humans, Male, Middle Aged, Magnetic Resonance Imaging, Nerve Fibers, Myelinated/*pathology, Magnetic Resonance Imaging/*methods, Brain/*pathology, CADASIL/*pathology, Neurons/*pathology, Brain, CADASIL, Nerve Fibers, Myelinated, Neurons},
pages = {72--6},
}
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The aim of this study was to evaluate the contrast alterations between gray matter and normal-appearing white matter on T1-weighted images in patients with CADASIL compared with healthy subjects. MATERIALS AND METHODS: Contrast between gray matter and normal-appearing white matter was assessed by using histogram analyses of 3D T1 high-resolution MR imaging in 23 patients with CADASIL at the initial stage of the disease (Mini-Mental State Examination score \\textgreater 24 and modified Rankin scale score \\textless/= 1; mean age, 53.5 +/- 11.1 years) and 30 age- and sex-matched controls. RESULTS: T1 contrast between gray matter and normal-appearing white matter was significantly reduced in patients compared with age- and sex-matched controls (patients: 1.35 +/- 0.08 versus controls: 1.43 +/- 0.04, P \\textless 10(-5)). This reduction was mainly driven by a signal decrease in normal-appearing white matter. Contrast loss was strongly related to the volume of white matter hyperintensities. CONCLUSIONS: Conventional 3D T1 imaging shows significant loss of contrast between gray matter and normal-appearing white matter in CADASIL. This probably reflects tissue changes in normal-appearing white matter outside signal abnormalities on T2 or FLAIR sequences. These contrast alterations should be taken into account for image interpretation and postprocessing.","number":"1","journal":"AJNR Am J Neuroradiol","author":[{"propositions":[],"lastnames":["De","Guio"],"firstnames":["F."],"suffixes":[]},{"propositions":[],"lastnames":["Reyes"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Duering"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Pirpamer"],"firstnames":["L."],"suffixes":[]},{"propositions":[],"lastnames":["Chabriat"],"firstnames":["H."],"suffixes":[]},{"propositions":[],"lastnames":["Jouvent"],"firstnames":["E."],"suffixes":[]}],"month":"January","year":"2014","pmid":"23868154","pmcid":"PMC7966464","keywords":"Adult, Aged, Female, Humans, Male, Middle Aged, Magnetic Resonance Imaging, Nerve Fibers, Myelinated/*pathology, Magnetic Resonance Imaging/*methods, Brain/*pathology, CADASIL/*pathology, Neurons/*pathology, Brain, CADASIL, Nerve Fibers, Myelinated, Neurons","pages":"72–6","bibtex":"@article{de_guio_decreased_2014,\n\ttitle = {Decreased {T1} contrast between gray matter and normal-appearing white matter in {CADASIL}},\n\tvolume = {35},\n\tissn = {1936-959X (Electronic) 0195-6108 (Linking)},\n\tdoi = {10.3174/ajnr.A3639},\n\tabstract = {BACKGROUND AND PURPOSE: CADASIL is the most frequent hereditary small-vessel disease of the brain. The clinical impact of various MR imaging markers has been repeatedly studied in this disorder, but alterations of contrast between gray matter and normal-appearing white matter remain unknown. The aim of this study was to evaluate the contrast alterations between gray matter and normal-appearing white matter on T1-weighted images in patients with CADASIL compared with healthy subjects. MATERIALS AND METHODS: Contrast between gray matter and normal-appearing white matter was assessed by using histogram analyses of 3D T1 high-resolution MR imaging in 23 patients with CADASIL at the initial stage of the disease (Mini-Mental State Examination score {\\textgreater} 24 and modified Rankin scale score {\\textless}/= 1; mean age, 53.5 +/- 11.1 years) and 30 age- and sex-matched controls. RESULTS: T1 contrast between gray matter and normal-appearing white matter was significantly reduced in patients compared with age- and sex-matched controls (patients: 1.35 +/- 0.08 versus controls: 1.43 +/- 0.04, P {\\textless} 10(-5)). This reduction was mainly driven by a signal decrease in normal-appearing white matter. Contrast loss was strongly related to the volume of white matter hyperintensities. CONCLUSIONS: Conventional 3D T1 imaging shows significant loss of contrast between gray matter and normal-appearing white matter in CADASIL. This probably reflects tissue changes in normal-appearing white matter outside signal abnormalities on T2 or FLAIR sequences. These contrast alterations should be taken into account for image interpretation and postprocessing.},\n\tnumber = {1},\n\tjournal = {AJNR Am J Neuroradiol},\n\tauthor = {De Guio, F. and Reyes, S. and Duering, M. and Pirpamer, L. and Chabriat, H. and Jouvent, E.},\n\tmonth = jan,\n\tyear = {2014},\n\tpmid = {23868154},\n\tpmcid = {PMC7966464},\n\tkeywords = {Adult, Aged, Female, Humans, Male, Middle Aged, Magnetic Resonance Imaging, Nerve Fibers, Myelinated/*pathology, Magnetic Resonance Imaging/*methods, Brain/*pathology, CADASIL/*pathology, Neurons/*pathology, Brain, CADASIL, Nerve Fibers, Myelinated, Neurons},\n\tpages = {72--6},\n}\n\n","author_short":["De Guio, F.","Reyes, S.","Duering, M.","Pirpamer, L.","Chabriat, H.","Jouvent, E."],"key":"de_guio_decreased_2014","id":"de_guio_decreased_2014","bibbaseid":"deguio-reyes-duering-pirpamer-chabriat-jouvent-decreasedt1contrastbetweengraymatterandnormalappearingwhitematterincadasil-2014","role":"author","urls":{},"keyword":["Adult","Aged","Female","Humans","Male","Middle Aged","Magnetic Resonance Imaging","Nerve Fibers","Myelinated/*pathology","Magnetic Resonance Imaging/*methods","Brain/*pathology","CADASIL/*pathology","Neurons/*pathology","Brain","CADASIL","Nerve Fibers","Myelinated","Neurons"],"metadata":{"authorlinks":{}},"downloads":0},"bibtype":"article","biburl":"https://marcoduering.github.io/mduering.bib","creationDate":"2020-12-23T09:31:30.710Z","downloads":0,"keywords":["adult","aged","female","humans","male","middle aged","magnetic resonance imaging","nerve fibers","myelinated/*pathology","magnetic resonance imaging/*methods","brain/*pathology","cadasil/*pathology","neurons/*pathology","brain","cadasil","nerve fibers","myelinated","neurons"],"search_terms":["decreased","contrast","between","gray","matter","normal","appearing","white","matter","cadasil","de guio","reyes","duering","pirpamer","chabriat","jouvent"],"title":"Decreased T1 contrast between gray matter and normal-appearing white matter in CADASIL","year":2014,"dataSources":["uWMC5v24T7d5wGjeH"]}