Decreased T1 contrast between gray matter and normal-appearing white matter in CADASIL. De Guio, F., Reyes, S., Duering, M., Pirpamer, L., Chabriat, H., & Jouvent, E. AJNR Am J Neuroradiol, 35(1):72–6, January, 2014.
doi  abstract   bibtex   
BACKGROUND AND PURPOSE: CADASIL is the most frequent hereditary small-vessel disease of the brain. The clinical impact of various MR imaging markers has been repeatedly studied in this disorder, but alterations of contrast between gray matter and normal-appearing white matter remain unknown. The aim of this study was to evaluate the contrast alterations between gray matter and normal-appearing white matter on T1-weighted images in patients with CADASIL compared with healthy subjects. MATERIALS AND METHODS: Contrast between gray matter and normal-appearing white matter was assessed by using histogram analyses of 3D T1 high-resolution MR imaging in 23 patients with CADASIL at the initial stage of the disease (Mini-Mental State Examination score \textgreater 24 and modified Rankin scale score \textless/= 1; mean age, 53.5 +/- 11.1 years) and 30 age- and sex-matched controls. RESULTS: T1 contrast between gray matter and normal-appearing white matter was significantly reduced in patients compared with age- and sex-matched controls (patients: 1.35 +/- 0.08 versus controls: 1.43 +/- 0.04, P \textless 10(-5)). This reduction was mainly driven by a signal decrease in normal-appearing white matter. Contrast loss was strongly related to the volume of white matter hyperintensities. CONCLUSIONS: Conventional 3D T1 imaging shows significant loss of contrast between gray matter and normal-appearing white matter in CADASIL. This probably reflects tissue changes in normal-appearing white matter outside signal abnormalities on T2 or FLAIR sequences. These contrast alterations should be taken into account for image interpretation and postprocessing.
@article{de_guio_decreased_2014,
	title = {Decreased {T1} contrast between gray matter and normal-appearing white matter in {CADASIL}},
	volume = {35},
	issn = {1936-959X (Electronic) 0195-6108 (Linking)},
	doi = {10.3174/ajnr.A3639},
	abstract = {BACKGROUND AND PURPOSE: CADASIL is the most frequent hereditary small-vessel disease of the brain. The clinical impact of various MR imaging markers has been repeatedly studied in this disorder, but alterations of contrast between gray matter and normal-appearing white matter remain unknown. The aim of this study was to evaluate the contrast alterations between gray matter and normal-appearing white matter on T1-weighted images in patients with CADASIL compared with healthy subjects. MATERIALS AND METHODS: Contrast between gray matter and normal-appearing white matter was assessed by using histogram analyses of 3D T1 high-resolution MR imaging in 23 patients with CADASIL at the initial stage of the disease (Mini-Mental State Examination score {\textgreater} 24 and modified Rankin scale score {\textless}/= 1; mean age, 53.5 +/- 11.1 years) and 30 age- and sex-matched controls. RESULTS: T1 contrast between gray matter and normal-appearing white matter was significantly reduced in patients compared with age- and sex-matched controls (patients: 1.35 +/- 0.08 versus controls: 1.43 +/- 0.04, P {\textless} 10(-5)). This reduction was mainly driven by a signal decrease in normal-appearing white matter. Contrast loss was strongly related to the volume of white matter hyperintensities. CONCLUSIONS: Conventional 3D T1 imaging shows significant loss of contrast between gray matter and normal-appearing white matter in CADASIL. This probably reflects tissue changes in normal-appearing white matter outside signal abnormalities on T2 or FLAIR sequences. These contrast alterations should be taken into account for image interpretation and postprocessing.},
	number = {1},
	journal = {AJNR Am J Neuroradiol},
	author = {De Guio, F. and Reyes, S. and Duering, M. and Pirpamer, L. and Chabriat, H. and Jouvent, E.},
	month = jan,
	year = {2014},
	pmid = {23868154},
	pmcid = {PMC7966464},
	keywords = {Adult, Aged, Female, Humans, Male, Middle Aged, Magnetic Resonance Imaging, Nerve Fibers, Myelinated/*pathology, Magnetic Resonance Imaging/*methods, Brain/*pathology, CADASIL/*pathology, Neurons/*pathology, Brain, CADASIL, Nerve Fibers, Myelinated, Neurons},
	pages = {72--6},
}

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