Neocortical inhibitory imbalance predicts successful sensory detection. Deister, C. A., Moore, A. I., Voigts, J., Bechek, S., Lichtin, R., Brown, T. C., & Moore, C. I. Cell Reports, 43(7):114233, July, 2024. ![Neocortical inhibitory imbalance predicts successful sensory detection [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Perceptual success depends on fast-spiking, parvalbumin-positive interneurons (FS/PVs). However, competing theories of optimal rate and correlation in pyramidal (PYR) firing make opposing predictions regarding the underlying FS/PV dynamics. We addressed this with population calcium imaging of FS/PVs and putative PYR neurons during threshold detection. In primary somatosensory and visual neocortex, a distinct PYR subset shows increased rate and spike-count correlations on detected trials (“hits”), while most show no rate change and decreased correlations. A larger fraction of FS/PVs predicts hits with either rate increases or decreases. Using computational modeling, we found that inhibitory imbalance, created by excitatory “feedback” and interactions between FS/PV pools, can account for the data. Rate-decreasing FS/PVs increase rate and correlation in a PYR subset, while rate-increasing FS/PVs reduce correlations and offset enhanced excitation in PYR neurons. These findings indicate that selection of informative PYR ensembles, through transient inhibitory imbalance, is a common motif of optimal neocortical processing.
@article{deister_neocortical_2024,
title = {Neocortical inhibitory imbalance predicts successful sensory detection},
volume = {43},
issn = {22111247},
url = {https://linkinghub.elsevier.com/retrieve/pii/S2211124724005618},
doi = {10.1016/j.celrep.2024.114233},
abstract = {Perceptual success depends on fast-spiking, parvalbumin-positive interneurons (FS/PVs). However, competing theories of optimal rate and correlation in pyramidal (PYR) firing make opposing predictions regarding the underlying FS/PV dynamics. We addressed this with population calcium imaging of FS/PVs and putative PYR neurons during threshold detection. In primary somatosensory and visual neocortex, a distinct PYR subset shows increased rate and spike-count correlations on detected trials (“hits”), while most show no rate change and decreased correlations. A larger fraction of FS/PVs predicts hits with either rate increases or decreases. Using computational modeling, we found that inhibitory imbalance, created by excitatory “feedback” and interactions between FS/PV pools, can account for the data. Rate-decreasing FS/PVs increase rate and correlation in a PYR subset, while rate-increasing FS/PVs reduce correlations and offset enhanced excitation in PYR neurons. These findings indicate that selection of informative PYR ensembles, through transient inhibitory imbalance, is a common motif of optimal neocortical processing.},
language = {en},
number = {7},
urldate = {2024-06-27},
journal = {Cell Reports},
author = {Deister, Christopher A. and Moore, Alexander I. and Voigts, Jakob and Bechek, Sophia and Lichtin, Rebecca and Brown, Tyler C. and Moore, Christopher I.},
month = jul,
year = {2024},
pages = {114233},
}
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