@article{RN307,
   author = {DeJong, N. R. and Jansen, J. F. A. and van Boxtel, M. P. J. and Schram, M. T. and Stehouwer, C. D. A. and Dagnelie, P. C. and van der Kallen, C. J. H. and Kroon, A. A. and Wesselius, A. and Koster, A. and Backes, W. H. and Kohler, S.},
   title = {Cognitive resilience depends on white matter connectivity: The Maastricht Study},
   journal = {Alzheimers Dement},
   note = {DeJong, Nathan R
Jansen, Jacobus F A
van Boxtel, Martin P J
Schram, Miranda T
Stehouwer, Coen D A
Dagnelie, Pieter C
van der Kallen, Carla J H
Kroon, Abraham A
Wesselius, Anke
Koster, Annemarie
Backes, Walter H
Kohler, Sebastian
eng
European Regional Development Fund via OP-Zuid
the Province of Limburg
31O.041/the Dutch Ministry of Economic Affairs
Stichting De Weijerhorst (Maastricht, The Netherlands)
the Pearl String Initiative Diabetes (Amsterdam, The Netherlands)
Cardiovascular Center (CVC, Maastricht, The Netherlands)
CARIM School for Cardiovascular Diseases (Maastricht, The Netherlands)
CAPHRI Care and Public Health Research Institute (Maastricht, The Netherlands)
NUTRIM School for Nutrition and Translational Research in Metabolism (Maastricht, The Netherlands)
MHeNs School for Mental Health and Neuroscience (Maastricht, The Netherlands)
Stichting Annadal (Maastricht, The Netherlands)
Health Foundation Limburg (Maastricht, The Netherlands)
Perimed (Jarfalla, Sweden)
Janssen-Cilag B.V. (Tilburg, The Netherlands)
Novo Nordisk Farma B.V. (Alphen aan den Rijn, The Netherlands)
Sanofi-Aventis Netherlands B.V. (Gouda, The Netherlands)
Alzheimers Dement. 2022 Aug 3. doi: 10.1002/alz.12758.},
   abstract = {INTRODUCTION: Differences in brain network connectivity may reflect the capability of the neurological substrate to compensate for brain damage and preserve cognitive function (cognitive reserve). We examined the associations between white matter connectivity, brain damage markers, and cognition in a population sample of middle-aged individuals. METHODS: A total of 4759 participants from The Maastricht Study (mean age = 59.2, SD = 8.7, 50.2% male) underwent cognitive testing and diffusion magnetic resonance imaging (dMRI), from which brain volume, structural connectivity, and vascular damage were quantified. Multivariable linear regression was used to investigate whether connectivity modified the association between brain damage and cognition, adjusted for demographic and cardiometabolic risk factors. RESULTS: More atrophic and vascular brain damage was associated with worse cognition scores. Increasing connectivity moderated the negative association between damage and cognition (chi(2) = 8.64, df = 3, p </= 0.001); individuals with high damage but strong connectivity showed normal cognition. DISCUSSION: Findings support the reserve hypothesis by showing that brain connectivity is associated with cognitive resilience.},
   keywords = {atrophy
brain damage
brain reserve
cerebral small vessel disease
cognition
cognitive reserve
diffusion MRI
epidemiology
executive function
information processing
memory
modifiable risk factors
networks
prevention
structural connectivity},
   ISSN = {1552-5279 (Electronic)
1552-5260 (Linking)},
   DOI = {10.1002/alz.12758},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/35920350},
   year = {2022},
   type = {Journal Article}
}

{"_id":"zoweJin9C9Zm9kkF2","bibbaseid":"dejong-jansen-vanboxtel-schram-stehouwer-dagnelie-vanderkallen-kroon-etal-cognitiveresiliencedependsonwhitematterconnectivitythemaastrichtstudy-2022","author_short":["DeJong, N. R.","Jansen, J. F. A.","van Boxtel, M. P. J.","Schram, M. T.","Stehouwer, C. D. A.","Dagnelie, P. C.","van der Kallen, C. J. H.","Kroon, A. A.","Wesselius, A.","Koster, A.","Backes, W. H.","Kohler, S."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["DeJong"],"firstnames":["N.","R."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]},{"propositions":["van"],"lastnames":["Boxtel"],"firstnames":["M.","P.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Schram"],"firstnames":["M.","T."],"suffixes":[]},{"propositions":[],"lastnames":["Stehouwer"],"firstnames":["C.","D.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Dagnelie"],"firstnames":["P.","C."],"suffixes":[]},{"propositions":["van","der"],"lastnames":["Kallen"],"firstnames":["C.","J.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Kroon"],"firstnames":["A.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Wesselius"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Koster"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Kohler"],"firstnames":["S."],"suffixes":[]}],"title":"Cognitive resilience depends on white matter connectivity: The Maastricht Study","journal":"Alzheimers Dement","note":"DeJong, Nathan R Jansen, Jacobus F A van Boxtel, Martin P J Schram, Miranda T Stehouwer, Coen D A Dagnelie, Pieter C van der Kallen, Carla J H Kroon, Abraham A Wesselius, Anke Koster, Annemarie Backes, Walter H Kohler, Sebastian eng European Regional Development Fund via OP-Zuid the Province of Limburg 31O.041/the Dutch Ministry of Economic Affairs Stichting De Weijerhorst (Maastricht, The Netherlands) the Pearl String Initiative Diabetes (Amsterdam, The Netherlands) Cardiovascular Center (CVC, Maastricht, The Netherlands) CARIM School for Cardiovascular Diseases (Maastricht, The Netherlands) CAPHRI Care and Public Health Research Institute (Maastricht, The Netherlands) NUTRIM School for Nutrition and Translational Research in Metabolism (Maastricht, The Netherlands) MHeNs School for Mental Health and Neuroscience (Maastricht, The Netherlands) Stichting Annadal (Maastricht, The Netherlands) Health Foundation Limburg (Maastricht, The Netherlands) Perimed (Jarfalla, Sweden) Janssen-Cilag B.V. (Tilburg, The Netherlands) Novo Nordisk Farma B.V. (Alphen aan den Rijn, The Netherlands) Sanofi-Aventis Netherlands B.V. (Gouda, The Netherlands) Alzheimers Dement. 2022 Aug 3. doi: 10.1002/alz.12758.","abstract":"INTRODUCTION: Differences in brain network connectivity may reflect the capability of the neurological substrate to compensate for brain damage and preserve cognitive function (cognitive reserve). We examined the associations between white matter connectivity, brain damage markers, and cognition in a population sample of middle-aged individuals. METHODS: A total of 4759 participants from The Maastricht Study (mean age = 59.2, SD = 8.7, 50.2% male) underwent cognitive testing and diffusion magnetic resonance imaging (dMRI), from which brain volume, structural connectivity, and vascular damage were quantified. Multivariable linear regression was used to investigate whether connectivity modified the association between brain damage and cognition, adjusted for demographic and cardiometabolic risk factors. RESULTS: More atrophic and vascular brain damage was associated with worse cognition scores. Increasing connectivity moderated the negative association between damage and cognition (chi(2) = 8.64, df = 3, p </= 0.001); individuals with high damage but strong connectivity showed normal cognition. DISCUSSION: Findings support the reserve hypothesis by showing that brain connectivity is associated with cognitive resilience.","keywords":"atrophy brain damage brain reserve cerebral small vessel disease cognition cognitive reserve diffusion MRI epidemiology executive function information processing memory modifiable risk factors networks prevention structural connectivity","issn":"1552-5279 (Electronic) 1552-5260 (Linking)","doi":"10.1002/alz.12758","url":"https://www.ncbi.nlm.nih.gov/pubmed/35920350","year":"2022","bibtex":"@article{RN307,\n author = {DeJong, N. R. and Jansen, J. F. A. and van Boxtel, M. P. J. and Schram, M. T. and Stehouwer, C. D. A. and Dagnelie, P. C. and van der Kallen, C. J. H. and Kroon, A. A. and Wesselius, A. and Koster, A. and Backes, W. H. and Kohler, S.},\n title = {Cognitive resilience depends on white matter connectivity: The Maastricht Study},\n journal = {Alzheimers Dement},\n note = {DeJong, Nathan R\nJansen, Jacobus F A\nvan Boxtel, Martin P J\nSchram, Miranda T\nStehouwer, Coen D A\nDagnelie, Pieter C\nvan der Kallen, Carla J H\nKroon, Abraham A\nWesselius, Anke\nKoster, Annemarie\nBackes, Walter H\nKohler, Sebastian\neng\nEuropean Regional Development Fund via OP-Zuid\nthe Province of Limburg\n31O.041/the Dutch Ministry of Economic Affairs\nStichting De Weijerhorst (Maastricht, The Netherlands)\nthe Pearl String Initiative Diabetes (Amsterdam, The Netherlands)\nCardiovascular Center (CVC, Maastricht, The Netherlands)\nCARIM School for Cardiovascular Diseases (Maastricht, The Netherlands)\nCAPHRI Care and Public Health Research Institute (Maastricht, The Netherlands)\nNUTRIM School for Nutrition and Translational Research in Metabolism (Maastricht, The Netherlands)\nMHeNs School for Mental Health and Neuroscience (Maastricht, The Netherlands)\nStichting Annadal (Maastricht, The Netherlands)\nHealth Foundation Limburg (Maastricht, The Netherlands)\nPerimed (Jarfalla, Sweden)\nJanssen-Cilag B.V. (Tilburg, The Netherlands)\nNovo Nordisk Farma B.V. (Alphen aan den Rijn, The Netherlands)\nSanofi-Aventis Netherlands B.V. (Gouda, The Netherlands)\nAlzheimers Dement. 2022 Aug 3. doi: 10.1002/alz.12758.},\n abstract = {INTRODUCTION: Differences in brain network connectivity may reflect the capability of the neurological substrate to compensate for brain damage and preserve cognitive function (cognitive reserve). We examined the associations between white matter connectivity, brain damage markers, and cognition in a population sample of middle-aged individuals. METHODS: A total of 4759 participants from The Maastricht Study (mean age = 59.2, SD = 8.7, 50.2% male) underwent cognitive testing and diffusion magnetic resonance imaging (dMRI), from which brain volume, structural connectivity, and vascular damage were quantified. Multivariable linear regression was used to investigate whether connectivity modified the association between brain damage and cognition, adjusted for demographic and cardiometabolic risk factors. RESULTS: More atrophic and vascular brain damage was associated with worse cognition scores. Increasing connectivity moderated the negative association between damage and cognition (chi(2) = 8.64, df = 3, p </= 0.001); individuals with high damage but strong connectivity showed normal cognition. 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