@article{de_moor_retrospective_2012,
	title = {A retrospective comparison of acute rhinosinusitis outcomes in patients prescribed antibiotics, mometasone furoate nasal spray, or both},
	volume = {26},
	issn = {1945-8932},
	doi = {10.2500/ajra.2012.26.3781},
	abstract = {BACKGROUND: Antibiotics are frequently used to treat acute rhinosinusitis (ARS; acute sinusitis), although many episodes are viral. Because of community resistance concerns, current evidence provides limited support for the use of antibiotics in ARS. We conducted a retrospective comparative effectiveness outcomes assessment of the nasal steroid mometasone furoate nasal spray (MFNS) versus antibiotics among ARS patients in clinical practice.
METHODS: Using the General Practice Research Database (United Kingdom), the earliest ARS event between January 1, 2005 and December 31, 2008 (index event) for patients aged 12-75 years and an antibiotic or MFNS prescription ±2 days was identified. Treatment cohorts were MFNS monotherapy (MM), MFNS + antibiotic (MAT), and antibiotic monotherapy (AM). Logistic regression adjusted for potential confounders and compared odds of rhinosinusitis-related medical encounters and related prescriptions in the 3- to 30-day postindex period.
RESULTS: There were 12,679 eligible patients (651 MM; 2285 MAT; 9743 AM). Compared with the reference cohort AM, during the 3- to 30-day postindex period, lower adjusted odds (p {\textless} 0.001) of having one or more rhinosinusitis-related medical encounters was observed for MM (odds ratio [OR] = 0.39; 95\% CI, 0.26-0.58) and MAT (OR = 0.51; 95\% CI, 0.42-0.62); having one or more rhinosinusitis-related prescriptions for MM (OR = 0.51; 95\% CI, 0.42-0.63) and MAT (OR = 0.58; 95\% CI, 0.52-0.65); having one or more antibiotic, nasal steroid, or oral steroid prescriptions for MM (OR = 0.36; 95\% CI, 0.28-0.46) and MAT (OR = 0.51; 95\% CI, 0.46-0.58); and having one or more antibiotic prescriptions for MM (OR = 0.43; 95\% CI, 0.33-0.58) and MAT (OR = 0.63; 95\% CI, (0.55-0.72).
CONCLUSION: Compared with AM, using MFNS for initial ARS treatment, alone or with an antibiotic, is associated with a decreased likelihood of both subsequent rhinosinusitis-related medical encounters and use of related prescriptions.},
	language = {eng},
	number = {4},
	journal = {American Journal of Rhinology \& Allergy},
	author = {de Moor, Carl and Reardon, Gregory and McLaughlin, John and Maiese, Eric M. and Navaratnam, Prakash},
	month = aug,
	year = {2012},
	pmid = {22801020},
	keywords = {Acute Disease, Adolescent, Adult, Aged, Anti-Bacterial Agents, Child, Cohort Studies, Female, Humans, Logistic Models, Male, Middle Aged, Nasal Sprays, Pregnadienediols, Retrospective Studies, Rhinitis, Sinusitis, Treatment Outcome},
	pages = {308--314}
}

{"_id":"bEJTtxBAkh7aoSNeX","bibbaseid":"demoor-reardon-mclaughlin-maiese-navaratnam-aretrospectivecomparisonofacuterhinosinusitisoutcomesinpatientsprescribedantibioticsmometasonefuroatenasalsprayorboth-2012","downloads":0,"creationDate":"2017-08-15T09:38:11.791Z","title":"A retrospective comparison of acute rhinosinusitis outcomes in patients prescribed antibiotics, mometasone furoate nasal spray, or both","author_short":["de Moor, C.","Reardon, G.","McLaughlin, J.","Maiese, E. M.","Navaratnam, P."],"year":2012,"bibtype":"article","biburl":"http://bibbase.org/zotero/veegee78","bibdata":{"bibtype":"article","type":"article","title":"A retrospective comparison of acute rhinosinusitis outcomes in patients prescribed antibiotics, mometasone furoate nasal spray, or both","volume":"26","issn":"1945-8932","doi":"10.2500/ajra.2012.26.3781","abstract":"BACKGROUND: Antibiotics are frequently used to treat acute rhinosinusitis (ARS; acute sinusitis), although many episodes are viral. Because of community resistance concerns, current evidence provides limited support for the use of antibiotics in ARS. We conducted a retrospective comparative effectiveness outcomes assessment of the nasal steroid mometasone furoate nasal spray (MFNS) versus antibiotics among ARS patients in clinical practice. METHODS: Using the General Practice Research Database (United Kingdom), the earliest ARS event between January 1, 2005 and December 31, 2008 (index event) for patients aged 12-75 years and an antibiotic or MFNS prescription ±2 days was identified. Treatment cohorts were MFNS monotherapy (MM), MFNS + antibiotic (MAT), and antibiotic monotherapy (AM). Logistic regression adjusted for potential confounders and compared odds of rhinosinusitis-related medical encounters and related prescriptions in the 3- to 30-day postindex period. RESULTS: There were 12,679 eligible patients (651 MM; 2285 MAT; 9743 AM). Compared with the reference cohort AM, during the 3- to 30-day postindex period, lower adjusted odds (p \\textless 0.001) of having one or more rhinosinusitis-related medical encounters was observed for MM (odds ratio [OR] = 0.39; 95% CI, 0.26-0.58) and MAT (OR = 0.51; 95% CI, 0.42-0.62); having one or more rhinosinusitis-related prescriptions for MM (OR = 0.51; 95% CI, 0.42-0.63) and MAT (OR = 0.58; 95% CI, 0.52-0.65); having one or more antibiotic, nasal steroid, or oral steroid prescriptions for MM (OR = 0.36; 95% CI, 0.28-0.46) and MAT (OR = 0.51; 95% CI, 0.46-0.58); and having one or more antibiotic prescriptions for MM (OR = 0.43; 95% CI, 0.33-0.58) and MAT (OR = 0.63; 95% CI, (0.55-0.72). CONCLUSION: Compared with AM, using MFNS for initial ARS treatment, alone or with an antibiotic, is associated with a decreased likelihood of both subsequent rhinosinusitis-related medical encounters and use of related prescriptions.","language":"eng","number":"4","journal":"American Journal of Rhinology & Allergy","author":[{"propositions":["de"],"lastnames":["Moor"],"firstnames":["Carl"],"suffixes":[]},{"propositions":[],"lastnames":["Reardon"],"firstnames":["Gregory"],"suffixes":[]},{"propositions":[],"lastnames":["McLaughlin"],"firstnames":["John"],"suffixes":[]},{"propositions":[],"lastnames":["Maiese"],"firstnames":["Eric","M."],"suffixes":[]},{"propositions":[],"lastnames":["Navaratnam"],"firstnames":["Prakash"],"suffixes":[]}],"month":"August","year":"2012","pmid":"22801020","keywords":"Acute Disease, Adolescent, Adult, Aged, Anti-Bacterial Agents, Child, Cohort Studies, Female, Humans, Logistic Models, Male, Middle Aged, Nasal Sprays, Pregnadienediols, Retrospective Studies, Rhinitis, Sinusitis, Treatment Outcome","pages":"308--314","bibtex":"@article{de_moor_retrospective_2012,\n\ttitle = {A retrospective comparison of acute rhinosinusitis outcomes in patients prescribed antibiotics, mometasone furoate nasal spray, or both},\n\tvolume = {26},\n\tissn = {1945-8932},\n\tdoi = {10.2500/ajra.2012.26.3781},\n\tabstract = {BACKGROUND: Antibiotics are frequently used to treat acute rhinosinusitis (ARS; acute sinusitis), although many episodes are viral. Because of community resistance concerns, current evidence provides limited support for the use of antibiotics in ARS. We conducted a retrospective comparative effectiveness outcomes assessment of the nasal steroid mometasone furoate nasal spray (MFNS) versus antibiotics among ARS patients in clinical practice.\nMETHODS: Using the General Practice Research Database (United Kingdom), the earliest ARS event between January 1, 2005 and December 31, 2008 (index event) for patients aged 12-75 years and an antibiotic or MFNS prescription ±2 days was identified. Treatment cohorts were MFNS monotherapy (MM), MFNS + antibiotic (MAT), and antibiotic monotherapy (AM). Logistic regression adjusted for potential confounders and compared odds of rhinosinusitis-related medical encounters and related prescriptions in the 3- to 30-day postindex period.\nRESULTS: There were 12,679 eligible patients (651 MM; 2285 MAT; 9743 AM). Compared with the reference cohort AM, during the 3- to 30-day postindex period, lower adjusted odds (p {\\textless} 0.001) of having one or more rhinosinusitis-related medical encounters was observed for MM (odds ratio [OR] = 0.39; 95\\% CI, 0.26-0.58) and MAT (OR = 0.51; 95\\% CI, 0.42-0.62); having one or more rhinosinusitis-related prescriptions for MM (OR = 0.51; 95\\% CI, 0.42-0.63) and MAT (OR = 0.58; 95\\% CI, 0.52-0.65); having one or more antibiotic, nasal steroid, or oral steroid prescriptions for MM (OR = 0.36; 95\\% CI, 0.28-0.46) and MAT (OR = 0.51; 95\\% CI, 0.46-0.58); and having one or more antibiotic prescriptions for MM (OR = 0.43; 95\\% CI, 0.33-0.58) and MAT (OR = 0.63; 95\\% CI, (0.55-0.72).\nCONCLUSION: Compared with AM, using MFNS for initial ARS treatment, alone or with an antibiotic, is associated with a decreased likelihood of both subsequent rhinosinusitis-related medical encounters and use of related prescriptions.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {American Journal of Rhinology \\& Allergy},\n\tauthor = {de Moor, Carl and Reardon, Gregory and McLaughlin, John and Maiese, Eric M. and Navaratnam, Prakash},\n\tmonth = aug,\n\tyear = {2012},\n\tpmid = {22801020},\n\tkeywords = {Acute Disease, Adolescent, Adult, Aged, Anti-Bacterial Agents, Child, Cohort Studies, Female, Humans, Logistic Models, Male, Middle Aged, Nasal Sprays, Pregnadienediols, Retrospective Studies, Rhinitis, Sinusitis, Treatment Outcome},\n\tpages = {308--314}\n}\n\n","author_short":["de Moor, C.","Reardon, G.","McLaughlin, J.","Maiese, E. 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