Reduced amygdala volume is associated with deficits in inhibitory control: A voxel- and surface-based morphometric analysis of comorbid PTSD/mild TBI. Depue, B., E.; Olson-Madden, J., H.; Smolker, H., R.; Rajamani, M.; Brenner, L., a.; and Banich, M., T. BioMed Research International, 2014.
Reduced amygdala volume is associated with deficits in inhibitory control: A voxel- and surface-based morphometric analysis of comorbid PTSD/mild TBI [pdf]Paper  abstract   bibtex   
A significant portion of previously deployed combat Veterans from Operation Enduring Freedom and Operation Iraqi Freedom/Operation New Dawn (OEF/OIF/OND) are affected by comorbid posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI). Despite this fact, neuroimaging studies investigating the neural correlates of cognitive dysfunction within this population are almost nonexistent, with the exception of research examining the neural correlates of diagnostic PTSD or TBI. The current study used both voxel-based and surface-based morphometry to determine whether comorbid PTSD/mTBI is characterized by altered brain structure in the same regions as observed in singular diagnostic PTSD or TBI. Furthermore, we assessed whether alterations in brain structures in these regions were associated with behavioral measures related to inhibitory control, as assessed by the Go/No-go task, self-reports of impulsivity, and/or PTSD or mTBI symptoms. Results indicate volumetric reductions in the bilateral anterior amygdala in our comorbid PTSD/mTBI sample as compared to a control sample of OEF/OIF Veterans with no history of mTBI and/or PTSD. Moreover, increased volume reduction in the amygdala predicted poorer inhibitory control as measured by performance on the Go/No-go task, increased self-reported impulsivity, and greater symptoms associated with PTSD. These findings suggest that alterations in brain anatomy in OEF/OIF/OND Veterans with comorbid PTSD/mTBI are associated with both cognitive deficits and trauma symptoms related to PTSD.
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 title = {Reduced amygdala volume is associated with deficits in inhibitory control: A voxel- and surface-based morphometric analysis of comorbid PTSD/mild TBI},
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 year = {2014},
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 keywords = {Adult,Amygdala,Amygdala: pathology,Amygdala: physiopathology,Brain Injuries,Brain Injuries: mortality,Brain Injuries: physiopathology,Brain Injuries: psychology,Cognition Disorders,Cognition Disorders: pathology,Cognition Disorders: physiopathology,Cognition Disorders: psychology,Female,Humans,Impulsive Behavior,Inhibition (Psychology),Male,Middle Aged,Stress Disorders, Post-Traumatic,Stress Disorders, Post-Traumatic: mortality,Stress Disorders, Post-Traumatic: pathology,Stress Disorders, Post-Traumatic: psychology},
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 abstract = {A significant portion of previously deployed combat Veterans from Operation Enduring Freedom and Operation Iraqi Freedom/Operation New Dawn (OEF/OIF/OND) are affected by comorbid posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI). Despite this fact, neuroimaging studies investigating the neural correlates of cognitive dysfunction within this population are almost nonexistent, with the exception of research examining the neural correlates of diagnostic PTSD or TBI. The current study used both voxel-based and surface-based morphometry to determine whether comorbid PTSD/mTBI is characterized by altered brain structure in the same regions as observed in singular diagnostic PTSD or TBI. Furthermore, we assessed whether alterations in brain structures in these regions were associated with behavioral measures related to inhibitory control, as assessed by the Go/No-go task, self-reports of impulsivity, and/or PTSD or mTBI symptoms. Results indicate volumetric reductions in the bilateral anterior amygdala in our comorbid PTSD/mTBI sample as compared to a control sample of OEF/OIF Veterans with no history of mTBI and/or PTSD. Moreover, increased volume reduction in the amygdala predicted poorer inhibitory control as measured by performance on the Go/No-go task, increased self-reported impulsivity, and greater symptoms associated with PTSD. These findings suggest that alterations in brain anatomy in OEF/OIF/OND Veterans with comorbid PTSD/mTBI are associated with both cognitive deficits and trauma symptoms related to PTSD.},
 bibtype = {article},
 author = {Depue, B. E. and Olson-Madden, J. H. and Smolker, H. R. and Rajamani, M. and Brenner, L. a. and Banich, M. T.},
 journal = {BioMed Research International}
}
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