Systematic review and network meta-analysis of overall survival comparing 3 mg/kg ipilimumab with alternative therapies in the management of pretreated patients with unresectable stage III or IV melanoma. Dequen, P., Lorigan, P., Jansen, J. P., van Baardewijk, M., Ouwens, M. J. N. M., & Kotapati, S. The Oncologist, 17(11):1376–1385, 2012.
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OBJECTIVE: To compare the overall survival (OS) of patients treated with 3 mg/kg ipilimumab versus alternative systemic therapies in pretreated unresectable stage III or IV melanoma patients. METHODS: A systematic literature search was performed to identify relevant randomized clinical trials. From these trials, Kaplan-Meier survival curves for each intervention were digitized and combined by means of a Bayesian network meta-analysis (NMA) to compare different drug classes. RESULTS: Of 38 trials identified, 15 formed one interlinked network by drug class to allow for an NMA. Ipilimumab, at a dose of 3 mg/kg, was associated with a greater mean OS time (18.8 months; 95% credible interval [CrI], 15.5-23.0 months) than single-agent chemotherapy (12.3 months; 95% CrI, 6.3-28.0 months), chemotherapy combinations (12.2 months; 95% CrI, 7.1-23.3 months), biochemotherapies (11.9 months; 95% CrI, 7.0-22.0 months), single-agent immunotherapy (11.1 months; 95% CrI, 8.5-16.2 months), and immunotherapy combinations (14.1 months; 95% CrI, 9.0-23.8 months). CONCLUSION: Results of this NMA were in line with previous findings and suggest that OS with ipilimumab is expected to be greater than with alternative systemic therapies, alone or in combination, for the management of pretreated patients with unresectable stage III or IV melanoma.
@article{dequen_systematic_2012,
	title = {Systematic review and network meta-analysis of overall survival comparing 3 mg/kg ipilimumab with alternative therapies in the management of pretreated patients with unresectable stage {III} or {IV} melanoma},
	volume = {17},
	issn = {1549-490X},
	doi = {10.1634/theoncologist.2011-0427},
	abstract = {OBJECTIVE: To compare the overall survival (OS) of patients treated with 3 mg/kg ipilimumab versus alternative systemic therapies in pretreated unresectable stage III or IV melanoma patients.
METHODS: A systematic literature search was performed to identify relevant randomized clinical trials. From these trials, Kaplan-Meier survival curves for each intervention were digitized and combined by means of a Bayesian network meta-analysis (NMA) to compare different drug classes.
RESULTS: Of 38 trials identified, 15 formed one interlinked network by drug class to allow for an NMA. Ipilimumab, at a dose of 3 mg/kg, was associated with a greater mean OS time (18.8 months; 95\% credible interval [CrI], 15.5-23.0 months) than single-agent chemotherapy (12.3 months; 95\% CrI, 6.3-28.0 months), chemotherapy combinations (12.2 months; 95\% CrI, 7.1-23.3 months), biochemotherapies (11.9 months; 95\% CrI, 7.0-22.0 months), single-agent immunotherapy (11.1 months; 95\% CrI, 8.5-16.2 months), and immunotherapy combinations (14.1 months; 95\% CrI, 9.0-23.8 months).
CONCLUSION: Results of this NMA were in line with previous findings and suggest that OS with ipilimumab is expected to be greater than with alternative systemic therapies, alone or in combination, for the management of pretreated patients with unresectable stage III or IV melanoma.},
	language = {eng},
	number = {11},
	journal = {The Oncologist},
	author = {Dequen, P. and Lorigan, P. and Jansen, J. P. and van Baardewijk, M. and Ouwens, M. J. N. M. and Kotapati, S.},
	year = {2012},
	pmid = {23024154},
	pmcid = {PMC3500357},
	keywords = {Antibodies, Monoclonal, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Humans, Immunotherapy, Ipilimumab, Kaplan-Meier Estimate, Melanoma, Neoplasm Staging, Skin Neoplasms, Survival Analysis, Treatment Outcome, oncology},
	pages = {1376--1385}
}

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