Microbleeds in postmortem brains of patients with Alzheimer disease: a T2*-weighted gradient-echo 7.0 T magnetic resonance imaging study. De Reuck, J. L., Cordonnier, C., Deramecourt, V., Auger, F., Durieux, N., Bordet, R., Maurage, C., Leys, D., & Pasquier, F. Alzheimer Disease and Associated Disorders, 27(2):162–167, June, 2013. doi abstract bibtex This study aims to determine the distribution and to quantify microbleeds (MBs) in postmortem brains of patients with Alzheimer disease (AD) on T2*-weighted gradient-echo 7.0 T magnetic resonance imaging. Twenty-eight AD brains were compared with 5 controls. The AD brains were subdivided further: 18 without and 10 with additional severe cerebral amyloid angiopathy (AD-CAA). The distribution and the number of cortical focal signal intensity losses, representing MBs, were assessed on coronal sections at the frontal, the central, and the occipital level of a cerebral hemisphere. MBs prevailed in the central sections (P=0.005) of AD brains without CAA, whereas in AD-CAA brains, they were more frequent in all coronal sections (P≤0.002). They prevailed in the deep cortical layers of the AD brains and of the controls (P≤0.03). They were significantly increased in all cortical layers of the AD-CAA brains (P≤0.04), compared with the controls. MBs prevalence in brains of AD patients had a different topographic distribution according to the absence or presence of severe CAA.
@article{de_reuck_microbleeds_2013,
title = {Microbleeds in postmortem brains of patients with {Alzheimer} disease: a {T2}*-weighted gradient-echo 7.0 {T} magnetic resonance imaging study},
volume = {27},
issn = {1546-4156},
shorttitle = {Microbleeds in postmortem brains of patients with {Alzheimer} disease},
doi = {10.1097/WAD.0b013e318256ecd8},
abstract = {This study aims to determine the distribution and to quantify microbleeds (MBs) in postmortem brains of patients with Alzheimer disease (AD) on T2*-weighted gradient-echo 7.0 T magnetic resonance imaging. Twenty-eight AD brains were compared with 5 controls. The AD brains were subdivided further: 18 without and 10 with additional severe cerebral amyloid angiopathy (AD-CAA). The distribution and the number of cortical focal signal intensity losses, representing MBs, were assessed on coronal sections at the frontal, the central, and the occipital level of a cerebral hemisphere. MBs prevailed in the central sections (P=0.005) of AD brains without CAA, whereas in AD-CAA brains, they were more frequent in all coronal sections (P≤0.002). They prevailed in the deep cortical layers of the AD brains and of the controls (P≤0.03). They were significantly increased in all cortical layers of the AD-CAA brains (P≤0.04), compared with the controls. MBs prevalence in brains of AD patients had a different topographic distribution according to the absence or presence of severe CAA.},
language = {eng},
number = {2},
journal = {Alzheimer Disease and Associated Disorders},
author = {De Reuck, Jacques L. and Cordonnier, Charlotte and Deramecourt, Vincent and Auger, Florent and Durieux, Nicolas and Bordet, Regis and Maurage, Claude-Alain and Leys, Didier and Pasquier, Florence},
month = jun,
year = {2013},
pmid = {22546781},
keywords = {Aged, Aged, 80 and over, Alzheimer Disease, Autopsy, Cerebral Amyloid Angiopathy, Cerebral Hemorrhage, Female, Humans, Magnetic Resonance Imaging, Male},
pages = {162--167},
}
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