Influence of age on the dynamics of fMRI activations during a semantic fluency task. Destrieux, C., Hommet, C., Domengie, F, Boissy, J., De Marco, G, Joanette, Y, Andersson, F., & Cottier, J. Journal of neuroradiology. Journal de neuroradiologie, 39(3):158--66, Elsevier Masson SAS, July, 2012.
Influence of age on the dynamics of fMRI activations during a semantic fluency task. [link]Paper  doi  abstract   bibtex   
PURPOSE: Age-related fMRI changes have not been extensively studied for language, whereas important adaptive mechanisms have been seen in other cognitive fields. This study examined age-related changes in fMRI activation during language tasks and, in particular, their dynamic course. PATIENTS AND METHODS: fMRI was performed on 22 young and 21 old healthy right-handed subjects during a silent category word-generation task. Activation and dynamics of BOLD signals were studied separately during the first and second portions of each 30-s block. RESULTS: Activation of the left frontal lobe was initially similar in young and old participants; however, it decreased after 30 s in the old participants. On the other hand, additional areas were initially involved only in old subjects and especially in the default mode network. CONCLUSION: This study showed age-related differences in the dynamics of fMRI activation during a silent word-generation task, suggesting a different pattern of language function with aging.
@article{Destrieux2012,
abstract = {PURPOSE: Age-related fMRI changes have not been extensively studied for language, whereas important adaptive mechanisms have been seen in other cognitive fields. This study examined age-related changes in fMRI activation during language tasks and, in particular, their dynamic course.

PATIENTS AND METHODS: fMRI was performed on 22 young and 21 old healthy right-handed subjects during a silent category word-generation task. Activation and dynamics of BOLD signals were studied separately during the first and second portions of each 30-s block.

RESULTS: Activation of the left frontal lobe was initially similar in young and old participants; however, it decreased after 30 s in the old participants. On the other hand, additional areas were initially involved only in old subjects and especially in the default mode network.

CONCLUSION: This study showed age-related differences in the dynamics of fMRI activation during a silent word-generation task, suggesting a different pattern of language function with aging.},
author = {Destrieux, Christophe and Hommet, Caroline and Domengie, F and Boissy, J-M and {De Marco}, G and Joanette, Y and Andersson, Fr\'{e}d\'{e}ric and Cottier, Jean-Philippe},
doi = {10.1016/j.neurad.2011.05.005},
file = {:C$\backslash$:/Users/emnicolas/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Destrieux et al. - 2012 - Influence of age on the dynamics of fMRI activations during a semantic fluency task.pdf:pdf},
issn = {0150-9861},
journal = {Journal of neuroradiology. Journal de neuroradiologie},
keywords = {Adult,Aged,Aged, 80 and over,Aging,Aging: physiology,Brain Mapping,Brain Mapping: methods,Cerebral Cortex,Cerebral Cortex: physiology,Female,Humans,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Reproducibility of Results,Semantics,Sensitivity and Specificity,Speech,Speech: physiology,Young Adult},
month = jul,
number = {3},
pages = {158--66},
pmid = {21741093},
publisher = {Elsevier Masson SAS},
title = {{Influence of age on the dynamics of fMRI activations during a semantic fluency task.}},
url = {http://www.ncbi.nlm.nih.gov/pubmed/21741093},
volume = {39},
year = {2012}
}

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