Influence of age on the dynamics of fMRI activations during a semantic fluency task. Destrieux, C., Hommet, C., Domengie, F., Boissy, J., Marco, G. D., Joanette, Y., Andersson, F., & Cottier, J. Journal of Neuroradiology. Journal De Neuroradiologie, 39(3):158--166, July, 2012.
doi  abstract   bibtex   
PURPOSE: Age-related fMRI changes have not been extensively studied for language, whereas important adaptive mechanisms have been seen in other cognitive fields. This study examined age-related changes in fMRI activation during language tasks and, in particular, their dynamic course. PATIENTS AND METHODS: fMRI was performed on 22 young and 21 old healthy right-handed subjects during a silent category word-generation task. Activation and dynamics of BOLD signals were studied separately during the first and second portions of each 30-s block. RESULTS: Activation of the left frontal lobe was initially similar in young and old participants; however, it decreased after 30 s in the old participants. On the other hand, additional areas were initially involved only in old subjects and especially in the default mode network. CONCLUSION: This study showed age-related differences in the dynamics of fMRI activation during a silent word-generation task, suggesting a different pattern of language function with aging.
@article{ destrieux_influence_2012,
  title = {Influence of age on the dynamics of {fMRI} activations during a semantic fluency task},
  volume = {39},
  issn = {0150-9861},
  doi = {10.1016/j.neurad.2011.05.005},
  abstract = {{PURPOSE}: Age-related {fMRI} changes have not been extensively studied for language, whereas important adaptive mechanisms have been seen in other cognitive fields. This study examined age-related changes in {fMRI} activation during language tasks and, in particular, their dynamic course.
{PATIENTS} {AND} {METHODS}: {fMRI} was performed on 22 young and 21 old healthy right-handed subjects during a silent category word-generation task. Activation and dynamics of {BOLD} signals were studied separately during the first and second portions of each 30-s block.
{RESULTS}: Activation of the left frontal lobe was initially similar in young and old participants; however, it decreased after 30 s in the old participants. On the other hand, additional areas were initially involved only in old subjects and especially in the default mode network.
{CONCLUSION}: This study showed age-related differences in the dynamics of {fMRI} activation during a silent word-generation task, suggesting a different pattern of language function with aging.},
  language = {eng},
  number = {3},
  journal = {Journal of Neuroradiology. Journal De Neuroradiologie},
  author = {Destrieux, C. and Hommet, C. and Domengie, F. and Boissy, J.-M. and De Marco, G. and Joanette, Y. and Andersson, F. and Cottier, J.-P.},
  month = {July},
  year = {2012},
  pmid = {21741093},
  keywords = {Adult, Aged, Aged, 80 and over, Aging, Brain Mapping, Cerebral Cortex, Female, Humans, Magnetic Resonance Imaging, Reproducibility of Results, Semantics, Sensitivity and Specificity, Speech, Young Adult},
  pages = {158--166}
}

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