Deep undepleted human serum proteome profiling toward biomarker discovery for Alzheimer’s disease. Dey, K. K., Wang, H., Niu, M., Bai, B., Wang, X., Li, Y., Cho, J., Tan, H., Mishra, A., High, A. A., Chen, P., Wu, Z., Beach, T. G., & Peng, J. Clinical Proteomics, 16(1):16, April, 2019. ![Deep undepleted human serum proteome profiling toward biomarker discovery for Alzheimer’s disease [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Blood-based protein measurement is a routine practice for detecting biomarkers in human disease. Comprehensive profiling of blood/plasma/serum proteome is a challenge due to an extremely large dynamic range, as exemplified by a small subset of highly abundant proteins. Antibody-based depletion of these abundant proteins alleviates the problem but introduces experimental variations. We aimed to establish a method for direct profiling of undepleted human serum and apply the method toward biomarker discovery for Alzheimer’s disease (AD), as AD is the most common form of dementia without available blood-based biomarkers in clinic.
@article{dey_deep_2019,
title = {Deep undepleted human serum proteome profiling toward biomarker discovery for {Alzheimer}’s disease},
volume = {16},
issn = {1559-0275},
url = {https://doi.org/10.1186/s12014-019-9237-1},
doi = {10.1186/s12014-019-9237-1},
abstract = {Blood-based protein measurement is a routine practice for detecting biomarkers in human disease. Comprehensive profiling of blood/plasma/serum proteome is a challenge due to an extremely large dynamic range, as exemplified by a small subset of highly abundant proteins. Antibody-based depletion of these abundant proteins alleviates the problem but introduces experimental variations. We aimed to establish a method for direct profiling of undepleted human serum and apply the method toward biomarker discovery for Alzheimer’s disease (AD), as AD is the most common form of dementia without available blood-based biomarkers in clinic.},
number = {1},
urldate = {2021-09-10},
journal = {Clinical Proteomics},
author = {Dey, Kaushik Kumar and Wang, Hong and Niu, Mingming and Bai, Bing and Wang, Xusheng and Li, Yuxin and Cho, Ji-Hoon and Tan, Haiyan and Mishra, Ashutosh and High, Anthony A. and Chen, Ping-Chung and Wu, Zhiping and Beach, Thomas G. and Peng, Junmin},
month = apr,
year = {2019},
keywords = {Alzheimer’s disease, Biomarker, Human blood, Mass spectrometry, Plasma, Proteome, Proteomics, Serum, Tandem mass tag},
pages = {16},
}
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