Time-resolved RNA signatures of CD4+ T cells in Parkinson’s disease. Diener, C., Hart, M., Kehl, T., Becker-Dorison, A., Tänzer, T., Schub, D., Krammes, L., Sester, M., Keller, A., Unger, M., Walch-Rückheim, B., Lenhof, H., & Meese, E. Cell Death Discovery, 9:18, 01, 2023. ![Time-resolved RNA signatures of CD4+ T cells in Parkinson’s disease [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Parkinson’s disease (PD) emerges as a complex, multifactorial disease. While there is increasing evidence that dysregulated T cells play a central role in PD pathogenesis, elucidation of the pathomechanical changes in related signaling is still in its beginnings. We employed time-resolved RNA expression upon the activation of peripheral CD4+ T cells to track and functionally relate changes on cellular signaling in representative cases of patients at different stages of PD. While only few miRNAs showed time-course related expression changes in PD, we identified groups of genes with significantly altered expression for each different time window. Towards a further understanding of the functional consequences, we highlighted pathways with decreased or increased activity in PD, including the most prominent altered IL-17 pathway. Flow cytometric analyses showed not only an increased prevalence of Th17 cells but also a specific subtype of IL-17 producing γδ-T cells, indicating a previously unknown role in PD pathogenesis.
@article{dc12023,
author = {Diener, Caroline and Hart, Martin and Kehl, Tim and Becker-Dorison, Anouck and Tänzer, Tanja and Schub, David and Krammes, Lena and Sester, Martina and Keller, Andreas and Unger, Marcus and Walch-Rückheim, Barbara and Lenhof, Hans-Peter and Meese, Eckart},
year = {2023},
month = {01},
pages = {18},
title = {Time-resolved RNA signatures of CD4+ T cells in Parkinson’s disease},
abstract = "{Parkinson’s disease (PD) emerges as a complex, multifactorial disease. While there is increasing evidence that dysregulated T cells play a central role in PD pathogenesis, elucidation of the pathomechanical changes in related signaling is still in its beginnings. We employed time-resolved RNA expression upon the activation of peripheral CD4+ T cells to track and functionally relate changes on cellular signaling in representative cases of patients at different stages of PD. While only few miRNAs showed time-course related expression changes in PD, we identified groups of genes with significantly altered expression for each different time window. Towards a further understanding of the functional consequences, we highlighted pathways with decreased or increased activity in PD, including the most prominent altered IL-17 pathway. Flow cytometric analyses showed not only an increased prevalence of Th17 cells but also a specific subtype of IL-17 producing γδ-T cells, indicating a previously unknown role in PD pathogenesis.}",
volume = {9},
journal = {Cell Death Discovery},
url = {https://doi.org/10.1038/s41420-023-01333-0},
doi = {10.1038/s41420-023-01333-0}
}
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