Auxin minimum triggers the developmental switch from cell division to cell differentiation in the <i>Arabidopsis</i> root. Di Mambro, R., De Ruvo, M., Pacifici, E., Salvi, E., Sozzani, R., Benfey, P. N., Busch, W., Novak, O., Ljung, K., Di Paola, L., Marée, A. F. M., Costantino, P., Grieneisen, V. A., & Sabatini, S. Proceedings of the National Academy of Sciences, 114(36):E7641–E7649, September, 2017. ![Auxin minimum triggers the developmental switch from cell division to cell differentiation in the <i>Arabidopsis</i> root [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex In multicellular organisms, a stringent control of the transition between cell division and differentiation is crucial for correct tissue and organ development. In the Arabidopsis root, the boundary between dividing and differentiating cells is positioned by the antagonistic interaction of the hormones auxin and cytokinin. Cytokinin affects polar auxin transport, but how this impacts the positional information required to establish this tissue boundary, is still unknown. By combining computational modeling with molecular genetics, we show that boundary formation is dependent on cytokinin’s control on auxin polar transport and degradation. The regulation of both processes shapes the auxin profile in a well-defined auxin minimum. This auxin minimum positions the boundary between dividing and differentiating cells, acting as a trigger for this developmental transition, thus controlling meristem size.
@article{di_mambro_auxin_2017,
title = {Auxin minimum triggers the developmental switch from cell division to cell differentiation in the \textit{{Arabidopsis}} root},
volume = {114},
issn = {0027-8424, 1091-6490},
url = {http://www.pnas.org/lookup/doi/10.1073/pnas.1705833114},
doi = {10/gbwhtt},
abstract = {In multicellular organisms, a stringent control of the transition between cell division and differentiation is crucial for correct tissue and organ development. In the
Arabidopsis
root, the boundary between dividing and differentiating cells is positioned by the antagonistic interaction of the hormones auxin and cytokinin. Cytokinin affects polar auxin transport, but how this impacts the positional information required to establish this tissue boundary, is still unknown. By combining computational modeling with molecular genetics, we show that boundary formation is dependent on cytokinin’s control on auxin polar transport and degradation. The regulation of both processes shapes the auxin profile in a well-defined auxin minimum. This auxin minimum positions the boundary between dividing and differentiating cells, acting as a trigger for this developmental transition, thus controlling meristem size.},
language = {en},
number = {36},
urldate = {2021-06-07},
journal = {Proceedings of the National Academy of Sciences},
author = {Di Mambro, Riccardo and De Ruvo, Micol and Pacifici, Elena and Salvi, Elena and Sozzani, Rosangela and Benfey, Philip N. and Busch, Wolfgang and Novak, Ondrej and Ljung, Karin and Di Paola, Luisa and Marée, Athanasius F. M. and Costantino, Paolo and Grieneisen, Verônica A. and Sabatini, Sabrina},
month = sep,
year = {2017},
pages = {E7641--E7649},
}
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In the Arabidopsis root, the boundary between dividing and differentiating cells is positioned by the antagonistic interaction of the hormones auxin and cytokinin. Cytokinin affects polar auxin transport, but how this impacts the positional information required to establish this tissue boundary, is still unknown. By combining computational modeling with molecular genetics, we show that boundary formation is dependent on cytokinin’s control on auxin polar transport and degradation. The regulation of both processes shapes the auxin profile in a well-defined auxin minimum. 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In the\n Arabidopsis\n root, the boundary between dividing and differentiating cells is positioned by the antagonistic interaction of the hormones auxin and cytokinin. Cytokinin affects polar auxin transport, but how this impacts the positional information required to establish this tissue boundary, is still unknown. By combining computational modeling with molecular genetics, we show that boundary formation is dependent on cytokinin’s control on auxin polar transport and degradation. The regulation of both processes shapes the auxin profile in a well-defined auxin minimum. 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