@article{Dinkele2024a,
abstract = {Pioneering studies linking symptomatic disease and cough-mediated release of Mycobacterium tuberculosis (Mtb) established the infectious origin of tuberculosis (TB), simultaneously informing the pervasive notion that pathology is a prerequisite for Mtb transmission. Our prior work has challenged this assumption: by sampling TB clinic attendees, we detected equivalent release of Mtb-containing bioaerosols by confirmed TB patients and individuals not receiving a TB diagnosis, and we demonstrated a time-dependent reduction in Mtb bioaerosol positivity during six-months' follow-up, irrespective of anti-TB chemotherapy. Now, by extending bioaerosol sampling to a randomly selected community cohort, we show that Mtb release is common in a TB-endemic setting: of 89 participants, 79.8{\%} (71/89) produced Mtb bioaerosols independently of QuantiFERON-TB Gold status, a standard test for Mtb infection; moreover, during two-months' longitudinal sampling, only 2{\%} (1/50) were serially Mtb bioaerosol negative. These results necessitate a reframing of the prevailing paradigm of Mtb transmission and infection, and may explain the current inability to elucidate Mtb transmission networks in TB-endemic regions.},
author = {Dinkele, Ryan and Gessner, Sophia and Patterson, Benjamin and McKerry, Andrea and Hoosen, Zeenat and Vazi, Andiswa and Seldon, Ronnett and Koch, Anastasia and Warner, Digby F and Wood, Robin},
doi = {10.1101/2024.04.02.24305196},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Dinkele et al. - 2024 - Persistent Mycobacterium tuberculosis bioaerosol release in a tuberculosis-endemic setting.pdf:pdf},
journal = {medRxiv},
keywords = {MEDLINE,NCBI,NIH,NLM,National Center for Biotechnology Information,National Institutes of Health,National Library of Medicine,OA,OA{\_}PMC,PMC11023659,Preprint,PubMed Abstract,Robin Wood,Ryan Dinkele,Sophia Gessner,doi:10.1101/2024.04.02.24305196,fund{\_}not{\_}ack,original,pmid:38633787},
mendeley-tags = {OA,OA{\_}PMC,fund{\_}not{\_}ack,original},
month = {apr},
pmid = {38633787},
publisher = {medRxiv},
title = {{Persistent Mycobacterium tuberculosis bioaerosol release in a tuberculosis-endemic setting}},
url = {https://pubmed.ncbi.nlm.nih.gov/38633787/ http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC11023659},
year = {2024}
}

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