{"_id":"6ptgTndK28yWfc56P","bibbaseid":"domart-benyamina-lemoine-bourgain-blecha-debuire-reynaud-saffroy-associationbetweenapolymorphisminthepromoterofaglutamatereceptorsubunitgenegrin2aandalcoholism-2012","author_short":["Domart, M.","Benyamina, A.","Lemoine, A.","Bourgain, C.","Blecha, L.","Debuire, B.","Reynaud, M.","Saffroy, R."],"bibdata":{"bibtype":"article","type":"article","title":"Association between a polymorphism in the promoter of a glutamate receptor subunit gene (GRIN2A) and alcoholism","volume":"17","issn":"1369-1600","url":"http://dx.doi.org/10.1111/j.1369-1600.2011.00321.x","doi":"10.1111/j.1369-1600.2011.00321.x","abstract":"A variable (GT)(n) repeat in the 5'-regulatory region of N-methyl-D-aspartate GRIN2A subtype has recently been identified and associated with psychiatric disorders. In this study, we examined the association of this polymorphism with alcohol dependence. Subject-control analysis included 206 alcohol-dependent and 168 control subjects. Average observed repeat numbers and genotype distributions were significantly different (P-value = 0.001) in alcohol-dependent subjects versus control subjects. Short alleles were significantly less frequent among alcohol-dependent subjects (odds ratio = 0.58, P-value = 7 × 10(-4)). These results could be replicated in an independent sample of 116 alcohol-dependent subjects. For the first time, a significant association was identified between this polymorphism and alcoholism.","number":"4","journal":"Addict Biol","author":[{"propositions":[],"lastnames":["Domart"],"firstnames":["Marie-Charlotte"],"suffixes":[]},{"propositions":[],"lastnames":["Benyamina"],"firstnames":["Amine"],"suffixes":[]},{"propositions":[],"lastnames":["Lemoine"],"firstnames":["Antoinette"],"suffixes":[]},{"propositions":[],"lastnames":["Bourgain"],"firstnames":["Catherine"],"suffixes":[]},{"propositions":[],"lastnames":["Blecha"],"firstnames":["Lisa"],"suffixes":[]},{"propositions":[],"lastnames":["Debuire"],"firstnames":["Brigitte"],"suffixes":[]},{"propositions":[],"lastnames":["Reynaud"],"firstnames":["Michel"],"suffixes":[]},{"propositions":[],"lastnames":["Saffroy"],"firstnames":["Raphaël"],"suffixes":[]}],"year":"2012","pages":"783–5","bibtex":"@article{domart_association_2012,\n\ttitle = {Association between a polymorphism in the promoter of a glutamate receptor subunit gene ({GRIN2A}) and alcoholism},\n\tvolume = {17},\n\tissn = {1369-1600},\n\turl = {http://dx.doi.org/10.1111/j.1369-1600.2011.00321.x},\n\tdoi = {10.1111/j.1369-1600.2011.00321.x},\n\tabstract = {A variable (GT)(n) repeat in the 5'-regulatory region of N-methyl-D-aspartate GRIN2A subtype has recently been identified and associated with psychiatric disorders. In this study, we examined the association of this polymorphism with alcohol dependence. Subject-control analysis included 206 alcohol-dependent and 168 control subjects. Average observed repeat numbers and genotype distributions were significantly different (P-value = 0.001) in alcohol-dependent subjects versus control subjects. Short alleles were significantly less frequent among alcohol-dependent subjects (odds ratio = 0.58, P-value = 7 × 10(-4)). These results could be replicated in an independent sample of 116 alcohol-dependent subjects. For the first time, a significant association was identified between this polymorphism and alcoholism.},\n\tnumber = {4},\n\tjournal = {Addict Biol},\n\tauthor = {Domart, Marie-Charlotte and Benyamina, Amine and Lemoine, Antoinette and Bourgain, Catherine and Blecha, Lisa and Debuire, Brigitte and Reynaud, Michel and Saffroy, Raphaël},\n\tyear = {2012},\n\tpages = {783--5},\n}\n\n","author_short":["Domart, M.","Benyamina, A.","Lemoine, A.","Bourgain, C.","Blecha, L.","Debuire, B.","Reynaud, M.","Saffroy, R."],"key":"domart_association_2012","id":"domart_association_2012","bibbaseid":"domart-benyamina-lemoine-bourgain-blecha-debuire-reynaud-saffroy-associationbetweenapolymorphisminthepromoterofaglutamatereceptorsubunitgenegrin2aandalcoholism-2012","role":"author","urls":{"Paper":"http://dx.doi.org/10.1111/j.1369-1600.2011.00321.x"},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"http://bibbase.org/zotero/biblioial","dataSources":["ftoP3zPyb2N3b9Noc"],"keywords":[],"search_terms":["association","between","polymorphism","promoter","glutamate","receptor","subunit","gene","grin2a","alcoholism","domart","benyamina","lemoine","bourgain","blecha","debuire","reynaud","saffroy"],"title":"Association between a polymorphism in the promoter of a glutamate receptor subunit gene (GRIN2A) and alcoholism","year":2012}