Association between a polymorphism in the promoter of a glutamate receptor subunit gene (GRIN2A) and alcoholism. Domart, M., Benyamina, A., Lemoine, A., Bourgain, C., Blecha, L., Debuire, B., Reynaud, M., & Saffroy, R. Addict Biol, 17(4):783–5, 2012.
Association between a polymorphism in the promoter of a glutamate receptor subunit gene (GRIN2A) and alcoholism [link]Paper  doi  abstract   bibtex   
A variable (GT)(n) repeat in the 5'-regulatory region of N-methyl-D-aspartate GRIN2A subtype has recently been identified and associated with psychiatric disorders. In this study, we examined the association of this polymorphism with alcohol dependence. Subject-control analysis included 206 alcohol-dependent and 168 control subjects. Average observed repeat numbers and genotype distributions were significantly different (P-value = 0.001) in alcohol-dependent subjects versus control subjects. Short alleles were significantly less frequent among alcohol-dependent subjects (odds ratio = 0.58, P-value = 7 × 10(-4)). These results could be replicated in an independent sample of 116 alcohol-dependent subjects. For the first time, a significant association was identified between this polymorphism and alcoholism.
@article{domart_association_2012,
	title = {Association between a polymorphism in the promoter of a glutamate receptor subunit gene ({GRIN2A}) and alcoholism},
	volume = {17},
	issn = {1369-1600},
	url = {http://dx.doi.org/10.1111/j.1369-1600.2011.00321.x},
	doi = {10.1111/j.1369-1600.2011.00321.x},
	abstract = {A variable (GT)(n) repeat in the 5'-regulatory region of N-methyl-D-aspartate GRIN2A subtype has recently been identified and associated with psychiatric disorders. In this study, we examined the association of this polymorphism with alcohol dependence. Subject-control analysis included 206 alcohol-dependent and 168 control subjects. Average observed repeat numbers and genotype distributions were significantly different (P-value = 0.001) in alcohol-dependent subjects versus control subjects. Short alleles were significantly less frequent among alcohol-dependent subjects (odds ratio = 0.58, P-value = 7 × 10(-4)). These results could be replicated in an independent sample of 116 alcohol-dependent subjects. For the first time, a significant association was identified between this polymorphism and alcoholism.},
	number = {4},
	journal = {Addict Biol},
	author = {Domart, Marie-Charlotte and Benyamina, Amine and Lemoine, Antoinette and Bourgain, Catherine and Blecha, Lisa and Debuire, Brigitte and Reynaud, Michel and Saffroy, Raphaël},
	year = {2012},
	pages = {783--5}
}

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