Tissue Distribution and Transfer to Eggs of Ingested α-Hexabromocyclododecane (α-HBCDD) in Laying Hens ( <i>Gallus domesticus</i> ). Dominguez-Romero, E.; Cariou, R.; Omer, E.; Marchand, P.; Dervilly-Pinel, G.; Le Bizec, B.; Travel, A.; and Jondreville, C. 64(10):2112–2119.
Tissue Distribution and Transfer to Eggs of Ingested α-Hexabromocyclododecane (α-HBCDD) in Laying Hens ( <i>Gallus domesticus</i> ) [link]Paper  doi  abstract   bibtex   
The aim of the current study was to describe the fate of ingested α-hexabromocyclododecane (α-HBCDD) in laying hens. Individuals were exposed to two dietary concentrations of α-HBCDD (50 and 5 ng g−1 feed) for 18 or 11 weeks followed by a 7-week decontamination period. The results show that no isomerization of α- to β- or γ-HBCDD forms occurred, whereas OH-HBCDD was identified as a product of α-HBCDD metabolism. Irrespective of the level of feed contamination, estimates of steady-state accumulation ratios were 5.2, 3.6, and 9.2 and half-lives were estimated at 17.4, 22.8, and 35.3 days in egg yolk, liver tissue, and abdominal fat, respectively. The steady-state carry-over rate to eggs was 22.9%. Thus, α-HBCDD ingested by laying hens is readily transferred to eggs and significantly accumulates in adipose tissue.
@article{dominguez-romero_tissue_2016,
	title = {Tissue Distribution and Transfer to Eggs of Ingested α-Hexabromocyclododecane (α-{HBCDD}) in Laying Hens ( \textit{Gallus domesticus} )},
	volume = {64},
	issn = {0021-8561, 1520-5118},
	url = {http://pubs.acs.org/doi/10.1021/acs.jafc.5b05574},
	doi = {10.1021/acs.jafc.5b05574},
	abstract = {The aim of the current study was to describe the fate of ingested α-hexabromocyclododecane (α-{HBCDD}) in laying hens. Individuals were exposed to two dietary concentrations of α-{HBCDD} (50 and 5 ng g−1 feed) for 18 or 11 weeks followed by a 7-week decontamination period. The results show that no isomerization of α- to β- or γ-{HBCDD} forms occurred, whereas {OH}-{HBCDD} was identified as a product of α-{HBCDD} metabolism. Irrespective of the level of feed contamination, estimates of steady-state accumulation ratios were 5.2, 3.6, and 9.2 and half-lives were estimated at 17.4, 22.8, and 35.3 days in egg yolk, liver tissue, and abdominal fat, respectively. The steady-state carry-over rate to eggs was 22.9\%. Thus, α-{HBCDD} ingested by laying hens is readily transferred to eggs and significantly accumulates in adipose tissue.},
	pages = {2112--2119},
	number = {10},
	journaltitle = {Journal of Agricultural and Food Chemistry},
	author = {Dominguez-Romero, Elena and Cariou, Ronan and Omer, Elsa and Marchand, Philippe and Dervilly-Pinel, Gaud and Le Bizec, Bruno and Travel, Angélique and Jondreville, Catherine},
	urldate = {2019-03-29},
	date = {2016-03-16},
	langid = {english},
	file = {Dominguez-Romero et al. - 2016 - Tissue Distribution and Transfer to Eggs of Ingest.pdf:C\:\\Users\\ygu\\Documents\\PCPOR066_YGU\\YGU\\Zotero\\storage\\BCD96IBL\\Dominguez-Romero et al. - 2016 - Tissue Distribution and Transfer to Eggs of Ingest.pdf:application/pdf}
}
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