Termination of pregnancy following prenatal diagnosis in France: how severe are the foetal anomalies?. Dommergues, M., Mandelbrot, L., Mahieu-Caputo, D., Boudjema, N., & Durand-Zaleski, I. Prenatal diagnosis, 30(6):531--9, June, 2010. ![Termination of pregnancy following prenatal diagnosis in France: how severe are the foetal anomalies? [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex OBJECTIVE: To determine how severe were the conditions leading to termination of pregnancy for foetal anomaly (TOPFA) in France. METHODS: Detailed indications for TOPFA were extracted from medical charts. RESULTS: Of 2465 completed records, indications were: chromosomal anomalies n = 963 (39.1%), malformations of a single organ without chromosomal or genetic aetiologies n = 898 (36.4%), multiple malformations without chromosomal or genetic aetiologies n = 238 (9.7%), obstetrical complications n = 161 (6.5%), non-chromosomal genetic diseases n = 158 (6.4%), foetal infections n = 21 (0.9%), unexplained severe oligohydramnios n = 20 (0.8%), foetal exposure to teratogenic agents n = 6. Overall, 33.3% of anomalies were lethal (e.g. anencephaly), 25.2% were expected to result in isolated mental retardation (e.g. Down) and 35.1% in substantial handicap (e.g. myelomeningocele). In 6.4% of cases, the anomaly was either of late onset (e.g. Huntington's disease) or with uncertain prognosis (e.g. agenesis of corpus callosum) or severity was debatable (e.g. single limb agenesis, sickle cell disease). CONCLUSIONS: Although there is no indisputable definition of which anomalies are 'severe', 93.6% of the decisions to terminate the pregnancy were made by women and professionals in reaction to anomalies which clearly were lethal or would lead to substantial physical and/or mental disabilities.
@article{Dommergues2010,
abstract = {OBJECTIVE: To determine how severe were the conditions leading to termination of pregnancy for foetal anomaly (TOPFA) in France. METHODS: Detailed indications for TOPFA were extracted from medical charts. RESULTS: Of 2465 completed records, indications were: chromosomal anomalies n = 963 (39.1\%), malformations of a single organ without chromosomal or genetic aetiologies n = 898 (36.4\%), multiple malformations without chromosomal or genetic aetiologies n = 238 (9.7\%), obstetrical complications n = 161 (6.5\%), non-chromosomal genetic diseases n = 158 (6.4\%), foetal infections n = 21 (0.9\%), unexplained severe oligohydramnios n = 20 (0.8\%), foetal exposure to teratogenic agents n = 6. Overall, 33.3\% of anomalies were lethal (e.g. anencephaly), 25.2\% were expected to result in isolated mental retardation (e.g. Down) and 35.1\% in substantial handicap (e.g. myelomeningocele). In 6.4\% of cases, the anomaly was either of late onset (e.g. Huntington's disease) or with uncertain prognosis (e.g. agenesis of corpus callosum) or severity was debatable (e.g. single limb agenesis, sickle cell disease). CONCLUSIONS: Although there is no indisputable definition of which anomalies are 'severe', 93.6\% of the decisions to terminate the pregnancy were made by women and professionals in reaction to anomalies which clearly were lethal or would lead to substantial physical and/or mental disabilities.},
author = {Dommergues, Marc and Mandelbrot, Laurent and Mahieu-Caputo, Dominique and Boudjema, Noel and Durand-Zaleski, Isabelle},
doi = {10.1002/pd.2510},
file = {:C$\backslash$:/Users/emnicolas/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Dommergues et al. - 2010 - Termination of pregnancy following prenatal diagnosis in France how severe are the foetal anomalies.pdf:pdf},
issn = {1097-0223},
journal = {Prenatal diagnosis},
keywords = {Abortion,Congenital Abnormalities,Congenital Abnormalities: diagnosis,Congenital Abnormalities: epidemiology,Congenital Abnormalities: etiology,Counseling,Counseling: statistics \& numerical data,Counseling: utilization,Eugenic,Eugenic: ethics,Eugenic: statistics \& numerical data,Eugenic: utilization,Female,France,France: epidemiology,Geography,Gestational Age,Humans,Infant,Live Birth,Live Birth: epidemiology,Newborn,Pregnancy,Prenatal Diagnosis,Prenatal Diagnosis: statistics \& numerical data,Prenatal Diagnosis: utilization,Severity of Illness Index},
month = jun,
number = {6},
pages = {531--9},
pmid = {20509152},
title = {{Termination of pregnancy following prenatal diagnosis in France: how severe are the foetal anomalies?}},
url = {http://onlinelibrary.wiley.com/doi/10.1002/pd.2510/full http://www.ncbi.nlm.nih.gov/pubmed/20509152},
volume = {30},
year = {2010}
}
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RESULTS: Of 2465 completed records, indications were: chromosomal anomalies n = 963 (39.1%), malformations of a single organ without chromosomal or genetic aetiologies n = 898 (36.4%), multiple malformations without chromosomal or genetic aetiologies n = 238 (9.7%), obstetrical complications n = 161 (6.5%), non-chromosomal genetic diseases n = 158 (6.4%), foetal infections n = 21 (0.9%), unexplained severe oligohydramnios n = 20 (0.8%), foetal exposure to teratogenic agents n = 6. Overall, 33.3% of anomalies were lethal (e.g. anencephaly), 25.2% were expected to result in isolated mental retardation (e.g. Down) and 35.1% in substantial handicap (e.g. myelomeningocele). In 6.4% of cases, the anomaly was either of late onset (e.g. Huntington's disease) or with uncertain prognosis (e.g. agenesis of corpus callosum) or severity was debatable (e.g. single limb agenesis, sickle cell disease). 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