@article{dommett_features_2012,
	title = {Features of childhood cancer in primary care: a population-based nested case-control study},
	volume = {106},
	issn = {1532-1827},
	shorttitle = {Features of childhood cancer in primary care},
	doi = {10.1038/bjc.2011.600},
	abstract = {BACKGROUND: This study investigated the risk of cancer in children with alert symptoms identified in current UK guidance, or with increased consultation frequency in primary care.
METHODS: A population-based, nested case-control study used data from the General Practice Research Database. In all, 1267 children age 0-14 years diagnosed with childhood cancer were matched to 15,318 controls. Likelihood ratios and positive predictive values (PPVs) were calculated to assess risk.
RESULTS: Alert symptoms recorded in the 12 and 3 months before diagnosis were present in 33.7\% and 27.0\% of cases vs 5.4\% and 1.4\% of controls, respectively. The PPV of having cancer for any alert symptom in the 3 months before diagnosis was 0.55 per 1000 children. Cases consulted more frequently particularly in the 3 months before diagnosis (86\% cases vs 41\% controls). Of these, 36\% of cases and 9\% of controls had consulted 4 times or more. The PPV for cancer in a child consulting 4 times or more in 3 months was 0.13 per 1000 children.
CONCLUSION: Alert symptoms and frequent consultations are associated with childhood cancer. However, individual symptoms and consultation patterns have very low PPVs for cancer in primary care (e.g., of 10,000 children with a recorded alert symptom, approximately 6 would be diagnosed with cancer within 3 months).},
	language = {eng},
	number = {5},
	journal = {British Journal of Cancer},
	author = {Dommett, R. M. and Redaniel, M. T. and Stevens, M. C. G. and Hamilton, W. and Martin, R. M.},
	month = feb,
	year = {2012},
	pmid = {22240793},
	pmcid = {PMC3307373},
	keywords = {Adolescent, Age Factors, Case-Control Studies, Child, Child, Preschool, Family Practice, Female, Great Britain, Humans, Infant, Male, Neoplasms, Population Surveillance, Primary Health Care, Risk},
	pages = {982--987}
}

{"_id":"zM2DgRF2aeYQwLtic","bibbaseid":"dommett-redaniel-stevens-hamilton-martin-featuresofchildhoodcancerinprimarycareapopulationbasednestedcasecontrolstudy-2012","downloads":0,"creationDate":"2017-08-15T09:38:11.604Z","title":"Features of childhood cancer in primary care: a population-based nested case-control study","author_short":["Dommett, R. M.","Redaniel, M. T.","Stevens, M. C. G.","Hamilton, W.","Martin, R. M."],"year":2012,"bibtype":"article","biburl":"http://bibbase.org/zotero/veegee78","bibdata":{"bibtype":"article","type":"article","title":"Features of childhood cancer in primary care: a population-based nested case-control study","volume":"106","issn":"1532-1827","shorttitle":"Features of childhood cancer in primary care","doi":"10.1038/bjc.2011.600","abstract":"BACKGROUND: This study investigated the risk of cancer in children with alert symptoms identified in current UK guidance, or with increased consultation frequency in primary care. METHODS: A population-based, nested case-control study used data from the General Practice Research Database. In all, 1267 children age 0-14 years diagnosed with childhood cancer were matched to 15,318 controls. Likelihood ratios and positive predictive values (PPVs) were calculated to assess risk. RESULTS: Alert symptoms recorded in the 12 and 3 months before diagnosis were present in 33.7% and 27.0% of cases vs 5.4% and 1.4% of controls, respectively. The PPV of having cancer for any alert symptom in the 3 months before diagnosis was 0.55 per 1000 children. Cases consulted more frequently particularly in the 3 months before diagnosis (86% cases vs 41% controls). Of these, 36% of cases and 9% of controls had consulted 4 times or more. The PPV for cancer in a child consulting 4 times or more in 3 months was 0.13 per 1000 children. CONCLUSION: Alert symptoms and frequent consultations are associated with childhood cancer. However, individual symptoms and consultation patterns have very low PPVs for cancer in primary care (e.g., of 10,000 children with a recorded alert symptom, approximately 6 would be diagnosed with cancer within 3 months).","language":"eng","number":"5","journal":"British Journal of Cancer","author":[{"propositions":[],"lastnames":["Dommett"],"firstnames":["R.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Redaniel"],"firstnames":["M.","T."],"suffixes":[]},{"propositions":[],"lastnames":["Stevens"],"firstnames":["M.","C.","G."],"suffixes":[]},{"propositions":[],"lastnames":["Hamilton"],"firstnames":["W."],"suffixes":[]},{"propositions":[],"lastnames":["Martin"],"firstnames":["R.","M."],"suffixes":[]}],"month":"February","year":"2012","pmid":"22240793","pmcid":"PMC3307373","keywords":"Adolescent, Age Factors, Case-Control Studies, Child, Child, Preschool, Family Practice, Female, Great Britain, Humans, Infant, Male, Neoplasms, Population Surveillance, Primary Health Care, Risk","pages":"982--987","bibtex":"@article{dommett_features_2012,\n\ttitle = {Features of childhood cancer in primary care: a population-based nested case-control study},\n\tvolume = {106},\n\tissn = {1532-1827},\n\tshorttitle = {Features of childhood cancer in primary care},\n\tdoi = {10.1038/bjc.2011.600},\n\tabstract = {BACKGROUND: This study investigated the risk of cancer in children with alert symptoms identified in current UK guidance, or with increased consultation frequency in primary care.\nMETHODS: A population-based, nested case-control study used data from the General Practice Research Database. In all, 1267 children age 0-14 years diagnosed with childhood cancer were matched to 15,318 controls. Likelihood ratios and positive predictive values (PPVs) were calculated to assess risk.\nRESULTS: Alert symptoms recorded in the 12 and 3 months before diagnosis were present in 33.7\\% and 27.0\\% of cases vs 5.4\\% and 1.4\\% of controls, respectively. The PPV of having cancer for any alert symptom in the 3 months before diagnosis was 0.55 per 1000 children. Cases consulted more frequently particularly in the 3 months before diagnosis (86\\% cases vs 41\\% controls). Of these, 36\\% of cases and 9\\% of controls had consulted 4 times or more. The PPV for cancer in a child consulting 4 times or more in 3 months was 0.13 per 1000 children.\nCONCLUSION: Alert symptoms and frequent consultations are associated with childhood cancer. However, individual symptoms and consultation patterns have very low PPVs for cancer in primary care (e.g., of 10,000 children with a recorded alert symptom, approximately 6 would be diagnosed with cancer within 3 months).},\n\tlanguage = {eng},\n\tnumber = {5},\n\tjournal = {British Journal of Cancer},\n\tauthor = {Dommett, R. M. and Redaniel, M. T. and Stevens, M. C. G. and Hamilton, W. and Martin, R. M.},\n\tmonth = feb,\n\tyear = {2012},\n\tpmid = {22240793},\n\tpmcid = {PMC3307373},\n\tkeywords = {Adolescent, Age Factors, Case-Control Studies, Child, Child, Preschool, Family Practice, Female, Great Britain, Humans, Infant, Male, Neoplasms, Population Surveillance, Primary Health Care, Risk},\n\tpages = {982--987}\n}\n\n","author_short":["Dommett, R. M.","Redaniel, M. T.","Stevens, M. C. G.","Hamilton, W.","Martin, R. M."],"key":"dommett_features_2012","id":"dommett_features_2012","bibbaseid":"dommett-redaniel-stevens-hamilton-martin-featuresofchildhoodcancerinprimarycareapopulationbasednestedcasecontrolstudy-2012","role":"author","urls":{},"keyword":["Adolescent","Age Factors","Case-Control Studies","Child","Child","Preschool","Family Practice","Female","Great Britain","Humans","Infant","Male","Neoplasms","Population Surveillance","Primary Health Care","Risk"],"downloads":0},"search_terms":["features","childhood","cancer","primary","care","population","based","nested","case","control","study","dommett","redaniel","stevens","hamilton","martin"],"keywords":["adolescent","age factors","case-control studies","child","child","preschool","family practice","female","great britain","humans","infant","male","neoplasms","population surveillance","primary health care","risk"],"authorIDs":[],"dataSources":["FmCWXwJibZiWNzpdc"]}